The Role of Noradrenaline and other Transmitter Hormones in the Pathogenesis of Hypertension

1976 ◽  
Vol 51 (s3) ◽  
pp. 427s-430s
Author(s):  
W. J. Louis ◽  
B. Jarrott ◽  
A. E. Doyle
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Essential Hypertension ◽  
Sympathetic Nervous System ◽  
Radioenzymatic Assay ◽  
The Central Nervous System ◽  
Serotonin Turnover ◽  
Mesenteric Vessels ◽  
Sympathetic Nervous

1. Studies with a sensitive radioenzymatic assay for plasma noradrenaline suggest there is a selective overactivity of the sympathetic nervous system in essential hypertension. 2. Serotonin turnover in the mesenteric vessels is approximately twice that of noradrenaline and it is suggested that serotonin may interact with noradrenaline to maintain vascular resistance. 3. Methodology which allows the study of local sympathetic turnover in nuclei of the central nervous system and in peripheral blood vessels is described. This approach has been used to study non-innervated sympathetic turnover observed in phaeochromocytoma.

scholarly journals Studies on the role of sympathetic nervous system in the mechanism of essential hypertension.

1977 ◽  
Vol 41 (3) ◽  
pp. 228-236
Author(s):  
MITSUO MIYAHARA ◽  
OSAMU IIMURA ◽  
TETSURO SHOJI ◽  
TAKAO OKADA
Keyword(s):  
Nervous System ◽  
Essential Hypertension ◽  
Sympathetic Nervous System ◽  
Sympathetic Nervous

scholarly journals Central regulation of circulation and arterial hypertension

2006 ◽  
Vol 12 (1) ◽  
pp. 66-79
Author(s):  
V. A. Tsyrlin
Keyword(s):  
Nervous System ◽  
Essential Hypertension ◽  
Autonomic Nervous System ◽  
Sympathetic Nervous System ◽  
Arterial Hypertension ◽  
Central Regulation ◽  
Sympathetic Nervous System Activity ◽  
Nervous System Activity ◽  
Sympathetic Nervous

Modern concepts about role of autonomic nervous system central regulation disturbance in pathogenesis of arterial hypertension are analysed in this article. Also it is examined presented hypothesis. explaining the increase of sympathetic nervous system activity and depression of vagal nerve tonuson experimental pathology at animals and essential hypertension at human.

Thyroid hormone-catecholamine interrelationships during exposure to cold

1981 ◽  
Vol 97 (1) ◽  
pp. 91-97 ◽  
Author(s):  
H. Storm ◽  
C. van Hardeveld ◽  
A. A. H. Kassenaar
Keyword(s):  
Nervous System ◽  
Plasma Concentration ◽  
Thyroid Hormone ◽  
Sympathetic Nervous System ◽  
Plasma Levels ◽  
Surgical Procedure ◽  
Exposure To Cold ◽  
Basal Plasma ◽  
Sympathetic Nervous

Abstract. Basal plasma levels for adrenalin (A), noradrenalin (NA), l-triiodothyronine (T3), and l-thyroxine (T4) were determined in rats with a chronically inserted catheter. The experiments described in this report were started 3 days after the surgical procedure when T3 and T4 levels had returned to normal. Basal levels for the catecholamines were reached already 4 h after the operation. The T3/T4 ratio in plasma was significantly increased after 3, 7, and 14 days in rats kept at 4°C and the same holds for the iodide in the 24-h urine after 7 and 14 days at 4°C. The venous NA plasma concentration was increased 6- to 12-fold during the same period of exposure to cold, whereas the A concentration remained at the basal level. During infusion of NA at 23°C the T3/T4 ratio in plasma was significantly increased after 7 days compared to pair-fed controls, and the same holds for the iodide excretion in the 24-h urine. This paper presents further evidence for a role of the sympathetic nervous system on T4 metabolism in rats at resting conditions.

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