Abnormalities of Vitamin D Metabolism in Paget's Disease of Bone

1983 ◽  
Vol 64 (2) ◽  
pp. 65P-65P
Author(s):  
D.F. Guilland-Cumming ◽  
P.J. Lawson-Matthew ◽  
S.K. Johnson ◽  
D.J. Beard ◽  
A. Yates ◽  
...  
Keyword(s):  
Vitamin D ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone ◽  
Vitamin D Metabolism

ABNORMAL VITAMIN D METABOLISM IN PAGET'S DISEASE OF BONE

1985 ◽  
Vol 22 (4) ◽  
pp. 559-566 ◽  
Author(s):  
D. F. GUILLARD-CUMMING ◽  
D. J. BEARD ◽  
D. L. DOUGLAS ◽  
S. K. JOHNSON ◽  
P. J. LAWSON-MATTHEW ◽  
...  
Keyword(s):  
Vitamin D ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone ◽  
Vitamin D Metabolism

scholarly journals Prevalence of vitamin D deficiency is higher in patients with Paget's disease of bone compared with age-matched controls

2013 ◽  
Vol 57 (7) ◽  
pp. 509-512 ◽  
Author(s):  
Luiz Griz ◽  
Francisco Bandeira ◽  
Erik Trovão Diniz ◽  
Marcelo Cabral ◽  
Eduardo Freese
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Postmenopausal Women ◽  
Paget’S Disease ◽  
Hypovitaminosis D ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone ◽  
Elderly Men ◽  
Control Groups

OBJECTIVE: To investigate if vitamin D deficiency is more prevalent in patients with Paget's disease of bone (PDB) than in age-matched controls. SUBJECTS AND METHODS: We measured serum 25-OHD in 28 untreated patients with PDB and two control groups: 284 elderly men from an ongoing cohort from our department, and 151 postmenopausal women seen in our outpatient clinic for routine medical evaluation. RESULTS: The mean ± SD serum 25-OHD was significantly lower in subjects with PDB (23.76 ± 6.29 ng/mL) than in the control groups of elderly men (27.86 ± 13.52 ng/mL) and postmenopausal women (30.30 ± 9.59 ng/mL), p = 0.015. The prevalence of vitamin D deficiency considering a cut-off point of serum 25-OHD < 30 ng/mL was 85.7% in patients with PDB, and in elderly men and postmenopausal women it was 66.7 % and 54.3%, respectively (p < 0.001). CONCLUSION: These results suggest a high prevalence of hypovitaminosis D in patients with Paget's disease living in the tropics.

Paget’s Disease of Bone and Calcium Homeostasis: Focus on Bisphosphonate Treatment

2011 ◽  
Vol 119 (09) ◽  
pp. 519-524 ◽  
Author(s):  
S. Polyzos ◽  
A. Anastasilakis ◽  
P. Makras ◽  
E. Terpos
Keyword(s):  
Vitamin D ◽  
Secondary Hyperparathyroidism ◽  
Vitamin D Deficiency ◽  
Bone Disease ◽  
Bone Mineralization ◽  
Paget’S Disease ◽  
The Elderly ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone

AbstractPaget’s disease of bone (PDB) is the second most common metabolic bone disease. Bisphosphonates (BPs) are currently the drugs of choice for PDB. PDB and osteomalacia are both common in the elderly. The concept of relative vitamin D deficiency in patients with PDB was suggested long ago, but it has not yet elucidated. Both diseases predispose to fractures, but their combined action to fragility has not been studied yet. The older BPs, mainly etidronate, further inhibit bone mineralization. Mineralization defects have also been described in patients with PDB treated with pamidronate. Moreover, hypocalcemia and secondary hyperparathyroidism after treatment with BPs have been described in PDB. Hypocalcemia seems to be more severe after treatment with the more potent, intravenous zoledronic acid, which is currently the treatment of choice for PDB. The counteracting hyperparathyroidism pathophysiologically intends to increase renal reabsorption of calcium and 1.25-dihydroxy vitamin D production and to stimulate osteoclasts in order to prevent long-term hypocalcemia. However, the effect of PTH on osteoclasts is, at least partly, restricted in patients taking BPs. Secondary hyperparathyroidism is a potentially detrimental condition, especially in patients already suffering from another bone disease. Serum calcium and vitamin D deficiency should be restored before BP treatment and calcium and vitamin D administration should be possibly continued for longer after achieving normocalcemia, which may shorten the duration of secondary hyperparathyroidism.Mineralization defects and hypocalcemia with secondary hyperparathyroidism have been described in patients with Paget’s disease of bone treated with bisphosphonates. Secondary hyperparathyroidism may be a potentially detrimental condition for patients with Paget’s disease of bone.

scholarly journals Paget’s Disease of Bone Affecting Site With Orthopedic Hardware

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A210-A210
Author(s):  
Ivan A Serrano Santiago ◽  
Jessica Lucier ◽  
Steven Michael Petak
Keyword(s):  
Vitamin D ◽  
Bone Disease ◽  
Tibial Fracture ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Bone Architecture ◽  
Paget's Disease Of Bone ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D

Abstract Introduction: Paget’s disease of bone is a focal disorder of accelerated bone remodeling which leads to bone hypertrophy, cortical expansion and abnormal bone architecture. Either a single bone (monostotic) or multiple bones (polyostotic) can be affected. Although it has been suggested to be caused by a chronic slow viral infection of the bone, a cause and effect relationship has not been clearly established. Therefore, the etiology of Paget’s disease remains an uncertain and controversial topic of discussion. Case Description: A 62-year-old African American male with a past medical history of a left tibial fracture presented with worsening left leg pain for the past 6 months. He denied any recent traumatic events, falls or strenuous physical activity. Since the pain started, his ambulation had been significantly affected requiring the use of a cane for gait stability. His left tibial fracture occurred over 20 years ago after landing on another person’s foot while playing basketball. It was surgically treated with intramedullary nailing and metal rod insertion into the canal of the tibia. Since then, he remained an active person with no physical limitations or ailments until the recent developments that brought him to clinic. A left leg CT-Scan ordered for evaluation of the tibial hardware revealed cortical thickening, marrow expansion and coarse trabeculae throughout the majority of the tibia consistent with Paget’s disease. The hardware was intact with no peri-hardware lucency to suggest loosening or infection. His laboratory workup showed a normal alkaline phosphatase level (94 U/L; normal range 40 - 115 U/L) and low 25-OH Vitamin D level of 14. A Radionuclide Bone Scan done for evaluation of location and extent of bone disease resulted in diffusely abnormal uptake present in the left tibia with no other locations of suspicious uptake. After his 25-OH Vitamin D levels were replenished, a dose of Zoledronic acid IV infusion was given with significant improvement of pain several months after. Discussion: Paget’s disease of bone is the second most common bone disease after osteoporosis. Affected skeletal sites develop a disorganized mosaic of woven and lamellar bone more susceptible to deformities and fractures than normal bone. It is often asymptomatic, but classical features include bone pain experienced either at rest or with motion, cutaneous erythema and warmth. The goal of medical therapy is to relieve symptoms and to prevent future complications with high potency bisphosphonates. Although it is well known that Paget’s disease increase the risk of fractures, this case brings up an interesting take about the possibility of fractures managed with hardware placement increasing the risk of Paget’s disease in the involved site.

The action of the main therapeutic regimes on paget's disease of bone, with a note on the effect of vitamin d deficiency

1980 ◽  
Vol 23 (10) ◽  
pp. 1215-1234 ◽  
Author(s):  
C. De Nagant Deuxchaisnes ◽  
B. Maldague ◽  
J. Malghem ◽  
J. P. Devogelaer ◽  
J. P. Huaux ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone

Alterations in vitamin D metabolites during treatment of paget's disease of bone with calcitonin or etidronate

2009 ◽  
Vol 5 (11) ◽  
pp. 1121-1126 ◽  
Author(s):  
Rowena D. Devlin ◽  
Donald H. Gutteridge ◽  
Richard L. Prince ◽  
Robert W. Retallack ◽  
Graeme K. Worth
Keyword(s):  
Vitamin D ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Vitamin D Metabolites ◽  
Paget's Disease Of Bone

Paget's Disease of Bone

2006 ◽  
Vol 39 (11) ◽  
pp. 20
Author(s):  
Elizabeth Mechcatie ◽  
Lora T. McGlade
Keyword(s):  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone
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