Selective renal medullary damage and hypertension in the rat: The role of vasopressin

1986 ◽  
Vol 71 (2) ◽  
pp. 167-171 ◽  
Author(s):  
G. I. Russell ◽  
N. P. Godfrey ◽  
M. L. Forsling ◽  
R. F. Bing ◽  
H. Thurston ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Angiotensin Ii ◽  
Sympathetic Nervous System ◽  
Response Curve ◽  
Elevated Blood ◽  
Plasma Vasopressin ◽  
Normal Rat ◽  
Sympathetic Nervous

1. The induction of selective renal medullary damage by 2-bromoethylamine hydrobromide (BEA) results in polyuria and raised blood pressure. In view of the likely elevation of plasma vasopressin we have investigated the role of vasopressin (AVP) in the elevated blood pressure in this model. 2. Plasma vasopressin levels in BEA pretreated rats were raised significantly (2 ± 0.6 pg/ml vs 0.8 ± 0.1 in normal rat, P < 0.05) but not to pressor levels. 3. In addition, pressor responsiveness was investigated in renal medullary damaged rats. There was a reduced response to vasopressin and noradrenaline but no alteration with angiotensin II. A specific V1 receptor AVP antagonist [d(CH2)5Tyr(Me)AVP] produced no fall in blood pressure but returned the noradrenaline dose-response curve to normal. This suggests an interaction between vasopressin and the sympathetic nervous system in this model. 4. Thus there is no evidence that vasopressin contributes to the rise in blood pressure produced by chemical renal medullectomy and other mechanisms have to be sought.

Central blood pressure effects of substance P and angiotensin II: Role of the sympathetic nervous system and vasopressin

1981 ◽  
Vol 71 (1) ◽  
pp. 33-42 ◽  
Author(s):  
Thomas Unger ◽  
Wolfgang Rascher ◽  
Christine Schuster ◽  
Ranko Pavlovitch ◽  
Albert Schömig ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Angiotensin Ii ◽  
Substance P ◽  
Sympathetic Nervous System ◽  
Pressure Effects ◽  
Central Blood Pressure ◽  
Blood Pressure Effects ◽  
Sympathetic Nervous

Mechanism of Pressor Effects of Intraventricular Injection of Angiotensin II in the Rat: Role of Vasopressin and Renal Nerves

1982 ◽  
Vol 63 (3) ◽  
pp. 275-279 ◽  
Author(s):  
Hiromichi Suzuki ◽  
Kazuoki Kondo ◽  
Michiko Handa ◽  
Hiroshi Kawabe ◽  
Takao Saruta
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Angiotensin Ii ◽  
Intraventricular Injection ◽  
Renal Nerves ◽  
Plasma Vasopressin ◽  
Sympathetic Nervous ◽  
Renal Sympathetic ◽  
Stimulation Of

1. The role of the kidney and vasopressin in the increase of blood pressure obtained when angiotensin II is injected intraventricularly into rats has been investigated. 2. Intraventricular injection of angiotensin II led to a significant increase in blood pressure in the control and all sham-operated rats compared with that in unilaterally nephrectomized, one-kidney denervated rats and bilaterally nephrectomized rats. The degree of increase in blood pressure in unilaterally nephrectomized, one-kidney denervated rats was equal to that in bilaterally nephrectomized rats. 3. The increase in blood pressure in the bilaterally nephrectomized rats lasted significantly longer than that in the control and unilaterally nephrectomized, one-kidney denervated rats. 4. In the bilaterally nephrectomized rats plasma vasopressin was still higher 30 min after the intraventricular injection of angiotensin II than that of the control and unilaterally nephrectomized, one-kidney denervated rats. 5. These results suggest that the rise in blood pressure observed after intraventricular injection of angiotensin II is due partly to stimulation of the renal sympathetic nervous system and partly to increase in plasma vasopressin concentration.

scholarly journals Role of Sympathetic Nervous System in Cyclosporine-Induced Rise in Blood Pressure

Hypertension ◽  
1999 ◽  
Vol 34 (1) ◽  
pp. 102-106 ◽  
Author(s):  
Mario J. Carvalho ◽  
Anton H. van den Meiracker ◽  
Frans Boomsma ◽  
Joao Freitas ◽  
Arie J. Man in ‘t Veld ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Sympathetic Nervous System ◽  
Sympathetic Nervous

scholarly journals Roles for the sympathetic nervous system, renal nerves, and CNS melanocortin-4 receptor in the elevated blood pressure in hyperandrogenemic female rats

2015 ◽  
Vol 308 (8) ◽  
pp. R708-R713 ◽  
Author(s):  
Rodrigo Maranon ◽  
Roberta Lima ◽  
Frank T. Spradley ◽  
Jussara M. do Carmo ◽  
Howei Zhang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Sympathetic Nervous System ◽  
Female Rats ◽  
Elevated Blood Pressure ◽  
Renal Nerves ◽  
Female Rat ◽  
Elevated Blood ◽  
Melanocortin 4 Receptor ◽  
Sympathetic Nervous

Women with polycystic ovary syndrome (PCOS) have hyperandrogenemia and increased prevalence of risk factors for cardiovascular disease, including elevated blood pressure. We recently characterized a hyperandrogenemic female rat (HAF) model of PCOS [chronic dihydrotestosterone (DHT) beginning at 4 wk of age] that exhibits similar characteristics as women with PCOS. In the present studies we tested the hypotheses that the elevated blood pressure in HAF rats is mediated in part by sympathetic activation, renal nerves, and melanocortin-4 receptor (MC4R) activation. Adrenergic blockade with terazosin and propranolol or renal denervation reduced mean arterial pressure (MAP by telemetry) in HAF rats but not controls. Hypothalamic MC4R expression was higher in HAF rats than controls, and central nervous system MC4R antagonism with SHU-9119 (1 nmol/h icv) reduced MAP in HAF rats. Taking a genetic approach, MC4R null and wild-type (WT) female rats were treated with DHT or placebo from 5 to 16 wk of age. MC4R null rats were obese and had higher MAP than WT control rats, and while DHT increased MAP in WT controls, DHT failed to further increase MAP in MC4R null rats. These data suggest that increases in MAP with chronic hyperandrogenemia in female rats are due, in part, to activation of the sympathetic nervous system, renal nerves, and MC4R and may provide novel insights into the mechanisms responsible for hypertension in women with hyperandrogenemia such as PCOS.

scholarly journals Insulin and Blood Pressure Regulation : Role of Sodium Retention and Sympathetic Nervous System

1993 ◽  
Vol 57 (supplementIV) ◽  
pp. 1154-1156
Author(s):  
Toshio Kushiro ◽  
Hirofumi Tomiyama ◽  
Katsuo Kanmatsuse ◽  
Nagao Kajiwara
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Sympathetic Nervous System ◽  
Blood Pressure Regulation ◽  
Sodium Retention ◽  
Pressure Regulation ◽  
Sympathetic Nervous

Chronic antioxidant therapy lowers blood pressure in adult but not in young Dahl salt hypertensive rats: the role of sympathetic nervous system

2013 ◽  
Vol 208 (4) ◽  
pp. 340-349 ◽  
Author(s):  
I. Vaněčková ◽  
M. Vokurková ◽  
H. Rauchová ◽  
Z. Dobešová ◽  
O. Pecháňová ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Sympathetic Nervous System ◽  
Antioxidant Therapy ◽  
Hypertensive Rats ◽  
Sympathetic Nervous

Aging and Insulin Sensitivity: Role of Blood Pressure and Sympathetic Nervous System Activity

1993 ◽  
Vol 48 (6) ◽  
pp. M237-M243 ◽  
Author(s):  
M. A. Supiano ◽  
R. V. Hogikyan ◽  
L. A. Morrow ◽  
F. J. Ortiz-Alonso ◽  
W. H. Herman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Insulin Sensitivity ◽  
Sympathetic Nervous System ◽  
Sympathetic Nervous System Activity ◽  
System Activity ◽  
Nervous System Activity ◽  
Sympathetic Nervous

Nighttime blood pressure dipping: the role of the sympathetic nervous system

2002 ◽  
Vol 15 (2) ◽  
pp. 111-118 ◽  
Author(s):  
A. Sherwood ◽  
P. R. Steffen ◽  
J. A. Blumenthal ◽  
C. Kuhn ◽  
A. L. Hinderliter
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Sympathetic Nervous System ◽  
Nighttime Blood Pressure ◽  
Blood Pressure Dipping ◽  
Sympathetic Nervous

Plasma Dopamine β-Hydroxylase and Noradrenaline Amounts in Essential Hypertension

1973 ◽  
Vol 44 (6) ◽  
pp. 617-620 ◽  
Author(s):  
L. B. Geffen ◽  
R. A. Rush ◽  
W. J. Louis ◽  
A. E. Doyle
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Essential Hypertension ◽  
Sympathetic Nervous System ◽  
Diastolic Blood Pressure ◽  
Plasma Catecholamines ◽  
Plasma Noradrenaline ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Sympathetic Nervous

1. Plasma dopamine β-hydroxylase (DβH) amounts were measured by radioimmunoassay in twenty-eight patients, twenty of whom had essential hypertension. There was a positive correlation between resting diastolic blood pressure and plasma DβH concentration. 2. Plasma DβH amounts also correlated significantly with those of plasma noradrenaline (NA) in individual patients. 3. These findings provide further support for the conclusions drawn from studies of plasma catecholamines that the sympathetic nervous system contributes toward the maintenance of the elevated blood pressure in essential hypertension.

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