Chronic Alcohol Administration to the Rat Causes Hepatic Oxidant Stress and Vitamin a Deficiency

1988 ◽  
Vol 75 (s19) ◽  
pp. 33P-33P
Author(s):  
M Noble ◽  
AJK Williams ◽  
OTG Jones ◽  
RE Barry
Keyword(s):  
Vitamin A ◽  
Vitamin A Deficiency ◽  
Oxidant Stress ◽  
Chronic Alcohol ◽  
Alcohol Administration ◽  
Chronic Alcohol Administration

THE EFFECT OF CHRONIC ALCOHOL ADMINISTRATION UPON CARDIAC NUCLEOTIDE CONCENTRATIONS AND HISTOMORPHOMETRY

1994 ◽  
Vol 22 (3) ◽  
pp. 352S-352S
Author(s):  
VINOOD B. PATEL ◽  
JONATHAN R. SALISBURY ◽  
LORETA M. RODRIGUES ◽  
JOHN R. GRIFFITHS ◽  
PETER J. RICHARDSON ◽  
...  
Keyword(s):  
Chronic Alcohol ◽  
Alcohol Administration ◽  
Chronic Alcohol Administration

scholarly journals Acute and chronic alcohol administration: Effects on performance of zebrafish in a latent learning task

2015 ◽  
Vol 282 ◽  
pp. 76-83 ◽  
Author(s):  
Ana C. Luchiari ◽  
Diana C. Salajan ◽  
Robert Gerlai
Keyword(s):  
Learning Task ◽  
Latent Learning ◽  
Chronic Alcohol ◽  
Alcohol Administration ◽  
Chronic Alcohol Administration

scholarly journals Differential expression of microRNAs in the hippocampi of male and female rodents after chronic alcohol administration

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Mi Ran Choi ◽  
Jasmin Sanghyun Han ◽  
Yeung-Bae Jin ◽  
Sang-Rae Lee ◽  
In Young Choi ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Target Genes ◽  
The Other ◽  
Female Rats ◽  
Chronic Alcohol ◽  
Male And Female ◽  
Heavy Alcohol ◽  
Alcohol Administration ◽  
Heavy Alcohol Use ◽  
Chronic Alcohol Administration

Abstract Background Women are more vulnerable than men to the neurotoxicity and severe brain damage caused by chronic heavy alcohol use. In addition, brain damage due to chronic heavy alcohol use may be associated with sex-dependent epigenetic modifications. This study aimed to identify microRNAs (miRNAs) and their target genes that are differentially expressed in the hippocampi of male and female animal models in response to alcohol. Methods After chronic alcohol administration (3~3.5 g/kg/day) in male (control, n = 10; alcohol, n = 12) or female (control, n = 10; alcohol, n = 12) Sprague-Dawley rats for 6 weeks, we measured body weights and doublecortin (DCX; a neurogenesis marker) concentrations and analyzed up- or downregulated miRNAs using GeneChip miRNA 4.0 arrays. The differentially expressed miRNAs and their putative target genes were validated by RT-qPCR. Results Alcohol attenuated body weight gain only in the male group. On the other hand, alcohol led to increased serum AST in female rats and decreased serum total cholesterol concentrations in male rats. The expression of DCX was significantly reduced in the hippocampi of male alcohol-treated rats. Nine miRNAs were significantly up- or downregulated in male alcohol-treated rats, including upregulation of miR-125a-3p, let-7a-5p, and miR-3541, and downregulation of their target genes (Prdm5, Suv39h1, Ptprz1, Mapk9, Ing4, Wt1, Nkx3-1, Dab2ip, Rnf152, Ripk1, Lin28a, Apbb3, Nras, and Acvr1c). On the other hand, 7 miRNAs were significantly up- or downregulated in alcohol-treated female rats, including downregulation of miR-881-3p and miR-504 and upregulation of their target genes (Naa50, Clock, Cbfb, Arih1, Ube2g1, and Gng7). Conclusions These results suggest that chronic heavy alcohol use produces sex-dependent effects on neurogenesis and miRNA expression in the hippocampus and that sex differences should be considered when developing miRNA biomarkers to diagnose or treat alcoholics.

Degeneration of intrapancreatic nerve fibers after chronic alcohol administration in mice

1997 ◽  
Vol 21 (2) ◽  
pp. 165-171
Author(s):  
Zoltán Berger ◽  
Erzsébet Fehér
Keyword(s):  
Nerve Fibers ◽  
Chronic Alcohol ◽  
Alcohol Administration ◽  
Chronic Alcohol Administration

Myoblast Mitochondrial Adaptation to Chronic Alcohol Administration

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Danielle E. Levitt ◽  
Liz Simon ◽  
Patricia E. Molina
Keyword(s):  
Chronic Alcohol ◽  
Alcohol Administration ◽  
Chronic Alcohol Administration ◽  
Mitochondrial Adaptation

Water Metabolism in Rats Subjected to Chronic Alcohol Administration

2004 ◽  
Vol 97 (1) ◽  
pp. p9-p15 ◽  
Author(s):  
Alexandr Parlesak ◽  
Claus Pohl ◽  
J. Christian Bode ◽  
Christiane Bode
Keyword(s):  
Chronic Alcohol ◽  
Water Metabolism ◽  
Alcohol Administration ◽  
Chronic Alcohol Administration

Effects of chronic alcohol administration on synaptic membrane Na+Ca2+ exchange activity

1987 ◽  
Vol 414 (2) ◽  
pp. 239-244 ◽  
Author(s):  
M.L. Michaelis ◽  
E.K. Michaelis ◽  
E.W. Nunley ◽  
N. Galton
Keyword(s):  
Synaptic Membrane ◽  
Chronic Alcohol ◽  
Alcohol Administration ◽  
Chronic Alcohol Administration ◽  
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