Blood pressure, left ventricular mass and intracellular calcium in primary hyperparathyroidism

1990 ◽  
Vol 78 (2) ◽  
pp. 127-132 ◽  
Author(s):  
Anna F. Dominiczak ◽  
Fiona Lyall ◽  
James J. Morton ◽  
Henry J. Dargie ◽  
Iain T. Boyle ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Confidence Interval ◽  
Primary Hyperparathyroidism ◽  
Left Ventricular Mass ◽  
Left Ventricular Mass Index ◽  
Left Ventricular ◽  
Free Calcium ◽  
Ventricular Mass Index ◽  
Control Subjects ◽  
Ventricular Mass

1. Blood pressure, left ventricular mass and platelet cytosolic free calcium concentrations were measured in 23 patients with untreated primary hyperparathyroidism, 30 normotensive control subjects and 23 control subjects matched for age, sex and blood pressure. In 12 patients measurements were repeated after parathyroidectomy. 2. Patients with primary hyperparathyroidism had significantly elevated blood pressures (139 ± 6/86 ± 3 mmHg, mean ± sem) compared with control subjects (125 ± 2/78 ± 1 mmHg), but high values persisted after hypercalcaemia was corrected. 3. Despite chronic extracellular hypercalcaemia, intracellular free calcium levels were lower in patients with hyperparathyroidism than in controls matched for age, sex and blood pressure (median concentrations 81.5 nmol/l vs 93 nmol/l, 95% confidence interval 0.1 to 20.1; P < 0.05) and values tended to increase after parathyroidectomy. 4. Left ventricular mass index was increased in the primary hyperparathyroid group as compared with control subjects matched for age, sex and blood pressure (123 g/m2 vs 100 g/m2, 95% confidence interval −36.1 to −3.1; P = 0.03). Parathyroidectomy resulted in a small reduction of the left ventricular mass index (123.5 g/m2 vs 104 g/m2, 95% confidence interval 46.5 to 2.5; P = 0.1) but no change in blood pressure. 5. Hypertension and left ventricular hypertrophy in primary hyperparathyroidism are associated with relatively low levels of free calcium in platelets.

Is the burden of late hypertension and cardiovascular target organ damage in children and adolescents with coarctation of the aorta after early successful repair different to healthy controls?

2020 ◽  
Vol 30 (9) ◽  
pp. 1305-1312
Author(s):  
Ayşe Ağbaş ◽  
Selman Gökalp ◽  
Nur Canpolat ◽  
Salim Çalışkan ◽  
Funda Öztunç
Keyword(s):  
Blood Pressure ◽  
Children And Adolescents ◽  
Left Ventricular Mass ◽  
Left Ventricular Mass Index ◽  
Coarctation Of The Aorta ◽  
Left Ventricular ◽  
Masked Hypertension ◽  
Ventricular Mass Index ◽  
Ventricular Mass ◽  
Successful Repair

AbstractObjective:Cardiovascular morbidity is high in patients with coarctation of aorta even after successful repair. This study aimed to assess the frequency of late hypertension and the relationship between ambulatory hypertension and cardiovascular target organ damage in children and adolescents after early and successful repair of coarctation of the aorta.Methods:Twenty-five children and adolescents (mean age 13.5 ± 3.43 years) with repaired coarctation of the aorta (median age at repair 4 months, arm–leg gradient <20 mmHg) and 16 healthy controls were included. Office and ambulatory blood pressure, pulse wave velocity, and left ventricular mass index were assessed.Results:Both day- and night-time systolic blood pressure standard deviation score and left ventricular mass index were significantly higher in patients compared to controls (p ≤ 0.001 for all), whereas pulse wave velocity did not differ. The prevalence of masked hypertension, isolated nocturnal hypertension, and left ventricular hypertrophy were 40, 28, and 24%, respectively. Left ventricular mass index was higher in patients with sustained hypertension, masked hypertension, and normotension compared to controls (p < 0.05). In multivariate analysis, higher night-time systolic blood pressure standard deviation score was the only independent predictor of left ventricular mass index.Conclusion:The present study reveals a high prevalence of masked hypertension, isolated nocturnal hypertension, and left ventricular hypertrophy in children and adolescents with coarctation of the aorta even after early and successful repair. Ambulatory blood pressure monitoring should be considered to diagnose hypertension. All coarctation of aorta patients should be followed up lifelong and encouraged to establish a healthy lifestyle starting from childhood.

P3.1 SUB-MAXIMAL EXERCISE BLOOD PRESSURE RELATES TO LEFT VENTRICULAR MASS INDEX, BUT IS DEPENDENT ON LOW AEROBIC CAPACITY

2015 ◽  
Vol 12 (C) ◽  
pp. 10
Author(s):  
Martin Schultz* ◽  
Dean Picone ◽  
Rachel Climie ◽  
Costan Magnussen ◽  
Leah Wright ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Left Ventricular Mass ◽  
Aerobic Capacity ◽  
Left Ventricular Mass Index ◽  
Maximal Exercise ◽  
Left Ventricular ◽  
Ventricular Mass Index ◽  
Ventricular Mass ◽  
Exercise Blood Pressure

scholarly journals KORELASI ANTARA TEKANAN DARAH DAN INDEKS MASSA VENTRIKEL KIRI (LEFT VENTRICULAR MASS INDEX) PADA PENDERITA HIPERTENSI DI RSUP PROF. DR. R. D. KANDOU MANADO

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Asdiana Nur ◽  
Fransiska Lintong ◽  
Maya Moningka
Keyword(s):  
Blood Pressure ◽  
Left Ventricular Hypertrophy ◽  
Left Ventricular Mass ◽  
Ventricular Hypertrophy ◽  
Left Ventricular Mass Index ◽  
Pressure Control ◽  
Left Ventricular ◽  
Ventricular Mass Index ◽  
Consecutive Sampling ◽  
Ventricular Mass

Abstract: Left ventricular hypertrophy (LVH) is target organ damage of cardiac with high prevalence in patients with hypertension. Increase of left ventricular mass was caused by increase in wall thickness as compensatory mechanism to minimize wall stress in response to elevated blood pressure. Left Ventricular Mass Index (LVMI) is one of echocardiography parameters used to diagnose LVH. The purpose of this study is to know the correlation between blood pressure and LVMI in patients with hypertension. A cross sectional study was performed at Cardiac Vascular and Brain Centre/ Central General Hospital of Prof. Dr. R. D Kandou. Sample was determined with consecutive sampling. Blood pressure of subjects were measurement and LVMI were taken from medical record. Data were analyzed used SPSS 21. Fifty one subjects, including 34 subjects with adequate blood pressure control and 17 subjects with inadequate blood pressure control are enrolled with ≥60 years old and men (64.7%) mostly found in this study. Pearson Correlation Test found a positive and significant correlation between systolic blood pressure and LVMI (r=0.488;p<0.05) while Spearman Correlation Test found a positive but not significant correlation between diastolic blood pressure and LVMI (r=0.226;p>0.05). In conclusion, there is a positive correlation between blood pressure and LVMI in patients with hypertension but a significant correlation was just found between systolic blood pressure and LVMI.Keywords: hypertension, Left ventricular hypertrophy (LVH), blood pressure, echocardiography, left ventricular mass index (LVMI)Abstrak: Hipertrofi ventrikel kiri (Left Ventricular Hypertrophy= LVH) merupakan kerusakan target organ jantung dengan prevalensi yang tinggi pada penderita hipertensi. Peningkatan massa ventrikel kiri disebabkan oleh penebalan dinding ventrikel kiri sebagai mekanisme kompensasi untuk meminimalkan tegangan dinding akibat respon terhadap peningkatan tekanan darah. Indeks massa ventrikel kiri (Left Ventricular Mass Index= LVMI) merupakan salah satu parameter ekokardiografi yang digunakan dalam mendiagnosa LVH. Tujuan dari penelitian ini adalah mengetahui korelasi antara tekanan darah dan LVMI pada penderita hipertensi. Penelitian dengan desain potong lintang dilakukan di instalasi pusat jantung dan pembuluh darah RSUP Prof Dr. R. D. Kandou. Sampel ditentukan secara consecutive sampling. Pengukuran tekanan darah dilakukan pada subyek penelitian dan LVMI diperoleh dari rekam medik. Data dianalisa menggunakan SPSS 21. Sebanyak 51 subyek penelitian, termasuk 34 subyek dengan hipertensi terkontrol dan 17 subyek dengan hipertensi tidak terkontrol, terdaftar pada penelitian ini dengan usia ≥60 tahun (39,2%) dan pria (64,7%)paling banyak ditemukan.Uji Korelasi Pearson menemukan tekanan darah sistolik mempunyai korelasi positif dan signifikan dengan LVMI (r=0,488;p<0,05) sedangkan uji Korelasi Spearman menemukan korelasi yang positif namun tidak signifikan antara tekanan darah diastolik dan LVMI (r=0,226;p>0,05). kesimpulan dari penelitian ini adalah terdapat korelasi positif antara tekanan darah dan LVMI pada penderita hipertensi, namun hubungan yang signifikan hanya ditemukan antara tekanan darah sistolik dan LVMI.Kata Kunci : hipertensi, hipertrofi ventrikel kiri, tekanan darah, ekokardiografi, indeks massa ventrikel kiri

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