Deterioration in peak systolic velocity is closely related to ischaemia during angioplasty: a vectorcardiographic and tissue Doppler imaging study

2000 ◽  
Vol 100 (2) ◽  
pp. 137-143 ◽  
Author(s):  
Jens JENSEN ◽  
Lars-Åke BRODIN ◽  
Britta LIND ◽  
Sven V. ERIKSSON ◽  
Mats JENSEN-URSTAD ◽  
...  

We tested the hypothesis that the extent of signs of ischaemia detected by vectorcardiography (VCG) during elective coronary angioplasty (percutaneous transluminal coronary angioplasty; PTCA) is related to systolic and diastolic myocardial velocities, as determined by tissue Doppler echocardiography. A total of 15 patients undergoing PTCA (12 men/three women; age 61±9 years), without prior myocardial infarction and with an ejection fraction of > 50%, were included. The balloon inflation was repeated three times, with minimum intervals of 2 min between inflations. Tissue Doppler echocardiography was performed, in an apical two- or four-chamber view, before and at the end of each inflation. Peak systolic velocity, time-to-peak systolic velocity (TTP), peak early (Em) and late (Am) diastolic velocities, the Em/Am ratio and isovolumic relaxation time were measured in the basal segments of the left ventricle. VCG recordings were carried out during the whole procedure. ST vector magnitude (ST-VM) and ST change vector magnitude (STC-VM) were monitored. The total duration and area of each VCG change during inflation were calculated for each patient. Isovolumic relaxation time, peak Em and Am values and the Em/Am ratio did not change significantly during inflation. Peak systolic velocity decreased (6.7±2.0 to 5.3±1.9 cm/s; P < 0.001) and TTP increased (157±60 to 192±60 ms; P < 0.01) during inflation. Both STC-VM time (r = -0.68, P < 0.01) and STC-VM area (r = -0.68, P < 0.01) were related to peak systolic velocity during inflation. STC-VM time was also related (r = 0.55, P < 0.05) to the difference in peak systolic velocity during compared with before inflation. ST-VM was less closely related to peak systolic velocity. Thus the duration and degree of ischaemia, as measured by VCG, are related to peak systolic velocity in the basal segments of the left ventricle.

Author(s):  
Erman Cilsal

<p><strong>Objective:</strong> The present study aims to evaluate how the mode of delivery affects the alterations in myocar­dial functions of healthy newborns within the first month of life. </p><p><strong>study desıgn:</strong> This is a prospective review of 60 healthy term newborns whose cardiac functions were examined by M-mode and tissue Doppler echocardiography on the first day of their lives and subsequently at one month of age. </p><p><strong>Results:</strong> At the first visit, the tricuspid annular plane systolic excursion was significantly higher in vaginally delivered newborns. Mitral and tricuspid E velocities and E/E’ ratio of the right ventricle and isovolumic relaxation time of right ventricle were also significantly higher in newborns delivered by cesarean section. Both of the groups had statistically similar M-mode and tissue Doppler echocardiography measurements at the time of the second visit. Only the increase in the tricuspid A velocity and myocardial performance index measured from septum between the first and second visits were significantly higher in the cesarean delivery group. When compared with the first visit, both isovolumic contraction time and isovolumic relaxation time were lower between the groups but myocardial performance index values were increased without significance at the second visit.</p><p><strong>Conclusion:</strong> Diastolic indices were significantly elevated in newborns delivered by cesarean section than neonates delivered by vaginal route. After one-month-long follow up, an increase was observed in diastolic ventricle functions of the vaginally delivered newborns but this increase was statistically insignificant. Cesarean delivery might be associated with the impairment in ventricular functions and, thus, a delay in the improvement and maturation of cardiac functions.</p>


2003 ◽  
Vol 41 (6) ◽  
pp. 441
Author(s):  
Yuichi Notomi ◽  
Hirotsugu Yamada ◽  
Zoran B. Popovic ◽  
Jianxin Qin ◽  
Neil L. Greenberg ◽  
...  

2019 ◽  
Vol 29 (3) ◽  
pp. 319-324
Author(s):  
Hale Tuhan ◽  
Tülay Demircan ◽  
Ayca Altıncık ◽  
Gönül Çatlı ◽  
Özgür Kızılca ◽  
...  

AbstractAimThe present study aimed to evaluate systolic and diastolic myocardial function in children and adolescents with congenital adrenal hyperplasia.MethodsThe study included 44 children with the diagnosis of classic congenital adrenal hyperplasia and 39 healthy children whose age, pubertal status, and gender were similar to those of the patient group. Anthropometric parameters and 17-hydroxyprogesterone levels were measured, and bone age was calculated. The average daily hydrocortisone dose was calculated over the last 1-year file records. Hyperandrogenic state was defined according to bone age SD score (⩾2) and 17-hydroxyprogesterone levels (>10 ng/ml). Echocardiographic examinations were assessed by conventional two-dimensional Doppler echocardiography and tissue Doppler imaging.ResultsPatients had higher morphological parameters, such as left ventricular end-systolic diameter, interventricular septal thickness at end diastole, left ventricular posterior wall thickness at end diastole, left ventricular mass and index, than the control group (p<0.05). On pulsed-wave and tissue Doppler echocardiography, significant subclinical alterations were observed in systolic (isovolumic contraction time), diastolic (isovolumic relaxation time), and global left ventricular functional (myocardial performance index) parameters in the congenital adrenal hyperplasia group compared to the control group (p<0.05). In partial correlation analyses, after controlling the effect of hyperandrogenism, the mean hydrocortisone dosage was positively correlated with isovolumic relaxation time in congenital adrenal hyperplasia group (p<0.05).ConclusionThis study demonstrated that the patients with congenital adrenal hyperplasia are at risk for left ventricular hypertrophy, systolic and diastolic myocardial subclinical alterations. Overtreatment may be responsible for the increased risk of myocardial dysfunction in patients with congenital adrenal hyperplasia.


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