Integrin-linked kinase: a new member of the kinases involved in hypertensive end-organ damage?

2014 ◽  
Vol 127 (1) ◽  
pp. 15-17
Author(s):  
Takashi Obama ◽  
Satoru Eguchi
Keyword(s):  
Inflammatory Responses ◽  
Reactive Oxygen Species Generation ◽  
Focal Adhesions ◽  
Nuclear Factor Κb ◽  
Organ Damage ◽  
Cytoskeletal Dynamics ◽  
Integrin Linked Kinase ◽  
Future Direction ◽  
Actin Cytoskeletal Dynamics ◽  
Organ Dysfunctions

Integrin-linked kinase predominantly localizes at focal adhesions to regulate actin cytoskeletal dynamics, including cell migration and matrix remodelling. Although recent studies have suggested both physiological and pathophysiological roles of integrin-linked kinase in the cardiovascular and renal system, its involvement in hypertensive organ dysfunctions, such as those that occur in kidney, has not been investigated. In the present issue of Clinical Science, Alique and co-workers have demonstrated that angiotensin II-induced renal inflammatory responses were attenuated in mice with conditional deficiency of integrin-linked kinase, which were associated with suppression of nuclear factor κB activation and reactive oxygen species generation but not hypertension. The significance, potential mechanisms and future direction are presented and discussed in this Commentary.

scholarly journals Integrin-Linked Kinase Regulates Process Extension in Oligodendrocytes via Control of Actin Cytoskeletal Dynamics

2013 ◽  
Vol 33 (23) ◽  
pp. 9781-9793 ◽  
Author(s):  
R. W. O'Meara ◽  
J.-P. Michalski ◽  
C. Anderson ◽  
K. Bhanot ◽  
P. Rippstein ◽  
...  
Keyword(s):  
Cytoskeletal Dynamics ◽  
Integrin Linked Kinase ◽  
Actin Cytoskeletal Dynamics

scholarly journals Exosome-based delivery of super-repressor IκBα relieves sepsis-associated organ damage and mortality

2020 ◽  
Vol 6 (15) ◽  
pp. eaaz6980 ◽  
Author(s):  
Hojun Choi ◽  
Youngeun Kim ◽  
Amin Mirzaaghasi ◽  
Jaenyoung Heo ◽  
Yu Na Kim ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Umbilical Vein ◽  
Active Form ◽  
Active Role ◽  
Nuclear Factor Κb ◽  
Organ Damage ◽  
Therapeutic Drug ◽  
Delivery Vehicle ◽  
Septic Mouse ◽  
Umbilical Vein Endothelial Cells

As extracellular vesicles that play an active role in intercellular communication by transferring cellular materials to recipient cells, exosomes offer great potential as a natural therapeutic drug delivery vehicle. The inflammatory responses in various disease models can be attenuated through introduction of super-repressor IκB (srIκB), which is the dominant active form of IκBα and can inhibit translocation of nuclear factor κB into the nucleus. An optogenetically engineered exosome system (EXPLOR) that we previously developed was implemented for loading a large amount of srIκB into exosomes. We showed that intraperitoneal injection of purified srIκB-loaded exosomes (Exo-srIκBs) attenuates mortality and systemic inflammation in septic mouse models. In a biodistribution study, Exo-srIκBs were observed mainly in the neutrophils, and in monocytes to a lesser extent, in the spleens and livers of mice. Moreover, we found that Exo-srIκB alleviates inflammatory responses in monocytic THP-1 cells and human umbilical vein endothelial cells.

scholarly journals The localization and activity of sphingosine kinase 1 are coordinately regulated with actin cytoskeletal dynamics in macrophages. VOLUME 282 (2007) PAGES 23147-23162

2008 ◽  
Vol 283 (9) ◽  
pp. 5972
Author(s):  
David J. Kusner ◽  
Christopher R. Thompson ◽  
Natalie A. Melrose ◽  
Stuart M. Pitson ◽  
Lina M. Obeid ◽  
...  
Keyword(s):  
Sphingosine Kinase ◽  
Sphingosine Kinase 1 ◽  
Cytoskeletal Dynamics ◽  
Actin Cytoskeletal Dynamics

scholarly journals Bidirectional feedback between BCR signaling and actin cytoskeletal dynamics

FEBS Journal ◽  
2021 ◽  
Author(s):  
Anshuman Bhanja ◽  
Ivan Rey‐Suarez ◽  
Wenxia Song ◽  
Arpita Upadhyaya
Keyword(s):  
Bcr Signaling ◽  
Cytoskeletal Dynamics ◽  
Actin Cytoskeletal Dynamics

Toxicity assessment of metallic nickel nanoparticles in various biological models: An interplay of reactive oxygen species, oxidative stress, and apoptosis

2021 ◽  
pp. 074823372110110
Author(s):  
Shabnoor Iqbal ◽  
Farhat Jabeen ◽  
Abdul Shakoor Chaudhry ◽  
Muhammad Ajmal Shah ◽  
Gaber El-Saber Batiha
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Nickel Nanoparticles ◽  
Hypoxia Inducible Factor ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Volume Ratio ◽  
Nuclear Factor Κb ◽  
Metallic Nickel ◽  
Oxygen Species

Nickel nanoparticles (Ni-NPs) are widely used for multiple purposes in industries. Ni-NPs exposure is detrimental to ecosystems owing to widespread use, and so their toxicity is important to consider for real-world applications. This review mainly focuses on the notable pathophysiological activities of Ni-NPs in various research models. Ni-NPs are stated to be more toxic than bulk forms because of their larger surface area to volume ratio and are reported to provoke toxicity through reactive oxygen species generation, which leads to the upregulation of nuclear factor-κB and promotes further signaling cascades. Ni-NPs may contribute to provoking oxidative stress and apoptosis. Hypoxia-inducible factor 1α and mitogen-activated protein kinases pathways are involved in Ni-NPs associated toxicity. Ni-NPs trigger the transcription factors p-p38, p-JNK, p-ERK1/2, interleukin (IL)-3, TNF-α, IL-13, Fas, Cyt c, Bax, Bid protein, caspase-3, caspase-8, and caspase-9. Moreover, Ni-NPs have an occupational vulnerability and were reported to induce lung-related disorders owing to inhalation. Ni-NPs may cause serious effects on reproduction as Ni-NPs induced deleterious effects on reproductive cells (sperm and eggs) in animal models and provoked hormonal alteration. However, recent studies have provided limited knowledge regarding the important checkpoints of signaling pathways and less focused on the toxic limitation of Ni-NPs in humans, which therefore needs to be further investigated.

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