scholarly journals The Relationship Between Iron Deficiency Anemia and Sensorineural Hearing Loss in the Pediatric and Adolescent Population

2017 ◽  
Vol 26 (2) ◽  
pp. 155-162 ◽  
Author(s):  
Kathleen M. Schieffer ◽  
James R. Connor ◽  
James A. Pawelczyk ◽  
Deepa L. Sekhar
Keyword(s):  
Hearing Loss ◽  
Iron Deficiency ◽  
Sensorineural Hearing Loss ◽  
Children And Adolescents ◽  
Iron Deficiency Anemia ◽  
Medical Center ◽  
Pediatric Population ◽  
Sensorineural Hearing ◽  
Deficiency Anemia ◽  
Penn State

Purpose A correlation between iron deficiency anemia (IDA) and sudden sensorineural hearing loss (SNHL) was described in adults. In this study, we examined if there is a relationship between IDA and hearing loss in the pediatric population. Method This was a retrospective cohort study of data collected from the Informatics for Integrating Biology and the Bedside database from 2011 to 2016. Children and adolescents 4–21 years old seen at Penn State Milton S. Hershey Medical Center, Hershey, PA, were examined for hearing loss and IDA status. Hearing loss was determined by International Classification of Disease-9 and -10 codes, and IDA was determined by both low hemoglobin and serum ferritin levels for age and sex. Results We identified 20,113 patients. Prevalence of hearing loss and IDA was 1.7% and 2.3%, respectively. The prevalence of all hearing loss was 3.0% in the IDA cohort and 1.7% in those without IDA. Children and adolescents with IDA are at increased odds of developing SNHL (adjusted odds ratio: 3.67, 95% CI [1.60–7.30]). Conclusions Children with IDA demonstrate increased likelihood of SNHL. Although correction of IDA in those with hearing loss has yet to be linked to improvements in hearing outcomes, screening for and correcting IDA among pediatric patients will positively affect overall health status. Supplemental Material: https://doi.org/10.23641/asha.5087071

Low-Frequency Sensorineural Hearing Loss Associated With Iron-Deficiency Anemia

2021 ◽  
Vol 17 (5) ◽  
pp. 465-467
Author(s):  
Masakatsu Taki ◽  
◽  
Tatsuhisa Hasegawa ◽  
Yuzuru Ninoyu ◽  
Hiroaki Mohri ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Iron Deficiency ◽  
Sensorineural Hearing Loss ◽  
Iron Deficiency Anemia ◽  
Low Frequency ◽  
Sensorineural Hearing ◽  
Deficiency Anemia

Iron deficiency is associated with poor prognosis in idiopathic sudden sensorineural hearing loss

2021 ◽  
pp. 1-5
Author(s):  
T Kurioka ◽  
H Sano ◽  
S Furuki ◽  
T Yamashita
Keyword(s):  
Hearing Loss ◽  
Iron Deficiency ◽  
Sensorineural Hearing Loss ◽  
Prognostic Marker ◽  
Serum Iron ◽  
Complete Recovery ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Iron Level ◽  
Recovery Group

Abstract Objective The effects of iron deficiency on the prognosis of idiopathic sudden sensorineural hearing loss are unclear. This study aimed to investigate the association between serum iron levels and idiopathic sudden sensorineural hearing loss prognosis and its usefulness as an independent prognostic marker for idiopathic sudden sensorineural hearing loss. Methods The audiological and haematological data, including hearing recovery and serum iron levels, of 103 patients with idiopathic sudden sensorineural hearing loss evaluated between 2015 and 2018 were retrospectively analysed. Results The overall complete recovery rate was 16.5 per cent. Initial higher hearing threshold was associated with poor idiopathic sudden sensorineural hearing loss prognosis. Serum iron levels were significantly higher in the complete recovery group than in the non-complete recovery group (p < 0.05). Conclusion The possibility of complete recovery from idiopathic sudden sensorineural hearing loss was significantly lower with lower serum iron levels, suggesting that the serum iron level might be a novel prognostic marker for idiopathic sudden sensorineural hearing loss.

scholarly journals Comparative Study of the Effects of Lactoferrin versus Oral Iron Therapy in Obese Children and Adolescents with Iron Deficiency Anemia

2021 ◽  
pp. 104-114
Author(s):  
Manal Mahmoud Atia ◽  
Rasha Mohamed Gama ◽  
Mohamed Attia Saad ◽  
Mohammed Amr Hamam
Keyword(s):  
Iron Deficiency ◽  
Children And Adolescents ◽  
Iron Deficiency Anemia ◽  
Interleukin 6 ◽  
Oral Iron ◽  
Iron Therapy ◽  
Deficiency Anemia ◽  
Obese Children ◽  
Oral Iron Therapy ◽  
Serum Hepcidin

Greater prevalence of iron deficiency (ID) has been observed in overweight and obese children and adolescents. Hepcidin acts as a key regulator of iron metabolism. Hepcidin synthesis increases in response inflammatory cytokines especially Interleukin-6 (IL-6). Considering that obesity represents a low grade chronic inflammatory state, a high concentration of hepcidin has been found in obese children. Elevated hepcidin level in obese children is associated with diminished response to oral iron therapy. Lactoferrin is an iron-binding multifunctional glycoprotein and has strong capacity to modulate the inflammatory response by its capacity to reduce pro-inflammatory cytokine expression in vivo, including IL-6 and hepcidin. Aim of the Work: To compare the efficacy of lactoferrin versus oral iron therapy in treatment of obese children and adolescents with iron deficiency anemia and the effect of therapy on serum hepcidin and interleukin 6 levels. Methodology: This prospective randomized clinical trial was conducted on 40 obese children and adolescents aged between 6 –18 years suffering from iron deficiency anemia (IDA). They were equally randomized into one of 2 groups. Group A received regular oral lactoferrin in a dose of 100 mg/day. Group B received regular oral iron supplementation (Ferric hydroxide polymaltose) in a dose of 6 mg elemental iron/kg /day.Baseline investigations included complete blood count (CBC), iron profile (Serum ferritin, serum iron, total iron binding capacity (TIBC), transferrin saturation), serum Interleukin 6, and serum hepcidin. Reevaluation of CBC was done monthly while iron status parameters, serum IL-6 and serum hepcidin were reevaluated after 3 months of receiving regular therapy. Results: Significant elevations in hemoglobin, MCV, MCH, Serum ferritin, serum iron and transferrin saturation with lactoferrin therapy compared to oral iron therapy. Significantly Lower TIBC after 3 months of lactoferrin therapy while the decrease in TIBC was insignificant in the iron therapy group.Lower serum hepcidin and IL6 after 3 months of lactoferrin therapy with no significant change in serum hepcidin and IL6 after iron therapy. Conclusion: This study clearly demonstrated the superiority of lactoferrin over iron use as oral in the treatment of iron deficiency anemia in obese children not only for the better response of hematological and iron status parameters and less gastrointestinal side effects but also for its effect on decreasing inflammatory biomarkers as hepcidin and IL6.

scholarly journals Is Maternal Iron Deficiency Anemia Associated With Hearing Loss In Healthy Newborns

2020 ◽  
Vol 4 (36) ◽  
pp. 361-366
Author(s):  
And Yavuz ◽  
Betul Yakistiran ◽  
Mehmet Fatih Karsli
Keyword(s):  
Hearing Loss ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Maternal Iron

scholarly journals Sandifer Syndrome

2021 ◽  
Vol 3 (1) ◽  
pp. 30-32
Author(s):  
Juan Gomez
Keyword(s):  
Iron Deficiency ◽  
Gastroesophageal Reflux ◽  
Children And Adolescents ◽  
Hiatal Hernia ◽  
Iron Deficiency Anemia ◽  
Gastrointestinal Disorder ◽  
Deficiency Anemia ◽  
Neurological Manifestations ◽  
Upper Gastrointestinal

Sandifer syndrome, named after neurologist Paul Sandifer, was first reported by Marcel Kinsbourne in 1962, who noted an upper gastrointestinal disorder that occurs in children and adolescents with neurological manifestations. Sandifer syndrome is a neurobehavioral disorder that causes a series of paroxysmal dystonic movements in association with gastroesophageal reflux and, in some cases, with hiatal hernia. It is characterized by esophagitis, iron deficiency anemia, and is often mistaken for a seizure of epileptic origin.

Blue Sclerae: A Sign of Iron Deficiency Anemia in Children?

PEDIATRICS ◽  
1993 ◽  
Vol 91 (6) ◽  
pp. 1195-1196
Author(s):  
MAURICE BEGHETTI ◽  
BERNADETTE MERMILLOD ◽  
DANIEL S. HALPERIN
Keyword(s):  
Iron Deficiency ◽  
Clinical Sign ◽  
Iron Deficiency Anemia ◽  
Pediatric Population ◽  
Ethics Committee ◽  
Deficiency Anemia ◽  
Hospitalized Children ◽  
Industrialized Countries ◽  
Developmental Impairment ◽  
Blue Sclerae

An association between blue sclerae and iron deficiency anemia (IDA) was described in 1908 by W. Osler1 and confirmed recently in adults.2 In these studies, blue sclerae appeared more sensitive and equally specific as an indicator of IDA than mucosal pallor.4 Because IDA is common in young children even in industrialized countries, and since infants with IDA may be at risk for long-lasting developmental impairment,9-11 we carried out a survey to verify the validity of this association and to assess the value of this clinical sign in a pediatric population. SUBJECTS AND METHODS One hundred hospitalized children (median age 3.3 years, range 2 months to 17 years) were prospectively studied in accordance with the ethics committee of our institution.

Does the practice of sports or recreational activities improve the balance and gait of children and adolescents with sensorineural hearing loss? A systematic review

2020 ◽  
Vol 77 ◽  
pp. 144-155
Author(s):  
Renato S. Melo ◽  
Afonso Rodrigues Tavares-Netto ◽  
Alexandre Delgado ◽  
Carine Carolina Wiesiolek ◽  
Karla Mônica Ferraz ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Children And Adolescents ◽  
Sensorineural Hearing ◽  
Recreational Activities
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