Bradykinin is not involved in angiotensin converting enzyme modulation of ovarian steroidogenesis and prostaglandin production in frog Rana esculenta

2002 ◽  
Vol 175 (2) ◽  
pp. 123-128 ◽  
Author(s):  
M. BRAMUCCI ◽  
A. MIANO ◽  
A. GOBBETTI ◽  
M. ZERANI ◽  
L. QUASSINTI ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Rana Esculenta ◽  
Converting Enzyme ◽  
Ovarian Steroidogenesis ◽  
Prostaglandin Production ◽  
Enzyme Modulation

Purified angiotensin converting enzyme from Rana esculenta ovary influences ovarian steroidogenesis in vitro

2003 ◽  
Vol 59 (4) ◽  
pp. 269-276 ◽  
Author(s):  
A. Miano ◽  
L. Quassinti ◽  
E. Maccari ◽  
O. Murri ◽  
D. Amici ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Rana Esculenta ◽  
Converting Enzyme ◽  
Ovarian Steroidogenesis

scholarly journals Different modulation of steroidogenesis and prostaglandin production in frog ovary in vitro by ACE and ANG II

1997 ◽  
Vol 273 (6) ◽  
pp. R2089-R2096 ◽  
Author(s):  
Massimo Bramucci ◽  
Antonino Miano ◽  
Anna Gobbetti ◽  
Massimo Zerani ◽  
Luana Quassinti ◽  
...  
Keyword(s):  
Ace Inhibitors ◽  
Rana Esculenta ◽  
Prostaglandin E ◽  
Ang Ii ◽  
Ovarian Steroidogenesis ◽  
Water Frog ◽  
Prostaglandin Production ◽  
Prostaglandin F ◽  
17Β Estradiol

Our aim was to study the role of angiotensin-converting enzyme (ACE) and angiotensin II (ANG II) on ovarian steroidogenesis and prostaglandin production of amphibian. Hormonal effects of ACE, ACE inhibitors, synthetic bullfrog angiotensin I (ANG I), and [Val5]ANG II were compared on frog ovaries of postreproductive and prereproductive periods. Very high ACE activity was found in ovary of water frog ( Rana esculenta) compared with other frog tissues, and this activity was inhibited by the typical ACE inhibitors, captopril and lisinopril. Frog ovary tissue in postreproductive and prereproductive periods was incubated in vitro in the presence of ACE (2.5 mU/ml), captopril (0.1 mM), lisinopril (0.1 mM), [Val5]ANG II (1 μM), and synthetic bullfrog ANG I (1 μM). Production of 17β-estradiol, progesterone, androgens, and prostaglandins E2 and F2α was determined. The data showed a modulation of 17β-estradiol, progesterone, and prostaglandin E2 production by ovary ACE; on the other hand, [Val5]ANG II modulated the production of progesterone and prostaglandin F2α, whereas androgen production was not influenced. The present in vitro studies suggest the existence of two pathways independently regulated by ACE and ANG II modulating ovarian steroidogenesis and prostaglandin production.

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