t(14;18) chromosomal translocation in follicular lymphoma: an event occurring with almost equal frequency both at the D to JH and at later stages in the rearrangement process of the immunoglobulin heavy chain gene locus

1997 ◽  
Vol 99 (4) ◽  
pp. 866-872 ◽  
Author(s):  
Kostas Stamatopoulos ◽  
Christos Kosmas ◽  
Chrysoula Belessi ◽  
Theodora Papadaki ◽  
Stavroula Afendaki ◽  
...  
Keyword(s):  
Follicular Lymphoma ◽  
Heavy Chain ◽  
Gene Locus ◽  
Chromosomal Translocation ◽  
Immunoglobulin Heavy Chain ◽  
Chain Gene ◽  
Equal Frequency ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene ◽  
Rearrangement Process

scholarly journals The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene

Blood ◽  
1989 ◽  
Vol 73 (8) ◽  
pp. 2081-2085 ◽  
Author(s):  
JC Grimaldi ◽  
TC Meeker
Keyword(s):  
Heavy Chain ◽  
Acute Lymphocytic Leukemia ◽  
Chromosomal Translocation ◽  
Immunoglobulin Heavy Chain ◽  
Lymphocytic Leukemia ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene ◽  
Interleukin 3 ◽  
Chromosomal Breakpoints

Abstract Chromosomal translocations have proven to be important markers of the genetic abnormalities central to the pathogenesis of cancer. By cloning chromosomal breakpoints one can identify activated proto-oncogenes. We have studied a case of B-lineage acute lymphocytic leukemia (ALL) that was associated with peripheral blood eosinophilia. The chromosomal translocation t(5;14) (q31;q32) from this sample was cloned and studied at the molecular level. This translocation joined the immunoglobulin heavy chain joining (Jh) region to the promotor region of the interleukin-3 (IL-3) gene in opposite transcriptional orientations. The data suggest that activation of the IL-3 gene by the enhancer of the immunoglobulin heavy chain gene may play a central role in the pathogenesis of this leukemia and the associated eosinophilia.

scholarly journals Organization of the variable region of the immunoglobulin heavy-chain gene locus of the rat

2010 ◽  
Vol 62 (7) ◽  
pp. 479-486 ◽  
Author(s):  
Jacobus Hendricks ◽  
Peter Terpstra ◽  
Peter M. Dammers ◽  
Rajesh Somasundaram ◽  
Annie Visser ◽  
...  
Keyword(s):  
Heavy Chain ◽  
Gene Locus ◽  
Variable Region ◽  
Immunoglobulin Heavy Chain ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene

scholarly journals The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene

Blood ◽  
1989 ◽  
Vol 73 (8) ◽  
pp. 2081-2085 ◽  
Author(s):  
JC Grimaldi ◽  
TC Meeker
Keyword(s):  
Heavy Chain ◽  
Acute Lymphocytic Leukemia ◽  
Chromosomal Translocation ◽  
Immunoglobulin Heavy Chain ◽  
Lymphocytic Leukemia ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene ◽  
Interleukin 3 ◽  
Chromosomal Breakpoints

Chromosomal translocations have proven to be important markers of the genetic abnormalities central to the pathogenesis of cancer. By cloning chromosomal breakpoints one can identify activated proto-oncogenes. We have studied a case of B-lineage acute lymphocytic leukemia (ALL) that was associated with peripheral blood eosinophilia. The chromosomal translocation t(5;14) (q31;q32) from this sample was cloned and studied at the molecular level. This translocation joined the immunoglobulin heavy chain joining (Jh) region to the promotor region of the interleukin-3 (IL-3) gene in opposite transcriptional orientations. The data suggest that activation of the IL-3 gene by the enhancer of the immunoglobulin heavy chain gene may play a central role in the pathogenesis of this leukemia and the associated eosinophilia.

scholarly journals Two Forms of Loops Generate the Chromatin Conformation of the Immunoglobulin Heavy-Chain Gene Locus

Cell ◽  
2011 ◽  
Vol 147 (2) ◽  
pp. 332-343 ◽  
Author(s):  
Changying Guo ◽  
Tatiana Gerasimova ◽  
Haiping Hao ◽  
Irina Ivanova ◽  
Tirtha Chakraborty ◽  
...  
Keyword(s):  
Heavy Chain ◽  
Gene Locus ◽  
Immunoglobulin Heavy Chain ◽  
Chain Gene ◽  
Chromatin Conformation ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene

Characterization of the torafugu (Takifugu rubripes) immunoglobulin heavy chain gene locus

2015 ◽  
Vol 67 (3) ◽  
pp. 179-193 ◽  
Author(s):  
Xi Fu ◽  
Hong Zhang ◽  
Engkong Tan ◽  
Shugo Watabe ◽  
Shuichi Asakawa
Keyword(s):  
Heavy Chain ◽  
Gene Locus ◽  
Immunoglobulin Heavy Chain ◽  
Chain Gene ◽  
Takifugu Rubripes ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene
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