Regulation of iron metabolism in the acute-phase response: interferon γ and tumour necrosis factor α induce hypoferraemia, ferritin production and a decrease in circulating transferrin receptors in cancer patients

1998 ◽  
Vol 28 (7) ◽  
pp. 520-527 ◽  
Author(s):  
Feelders ◽  
Vreugdenhil ◽  
Eggermont ◽  
Kuiper-Kramer ◽  
Van Eijk ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Tumour Necrosis Factor ◽  
Iron Metabolism ◽  
Acute Phase Response ◽  
Tumour Necrosis ◽  
Interferon Γ ◽  
Transferrin Receptors ◽  
Tumour Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor

MEGAKARYOCYTIC DIFFERENTIATION OF HIMeg-1 CELLS INDUCED BY INTERFERON γ AND TUMOUR NECROSIS FACTOR α BUT NOT BY THROMBOPOIETIN

Cytokine ◽  
1998 ◽  
Vol 10 (11) ◽  
pp. 880-889 ◽  
Author(s):  
Jian Li ◽  
Robert S. Franco ◽  
Yisheng Wang ◽  
Hui-Qi Pan ◽  
Dan Eaton ◽  
...  
Keyword(s):  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Interferon Γ ◽  
Tumour Necrosis Factor Α ◽  
Megakaryocytic Differentiation ◽  
Factor Α ◽  
Necrosis Factor

Tumour Necrosis Factor-α Upregulates Transferrin Receptors in K 562 Cells

1994 ◽  
Vol 22 (3) ◽  
pp. 145-152 ◽  
Author(s):  
M Nezu ◽  
H Iwagaki ◽  
H Aoki ◽  
N Tanaka ◽  
K Orita
Keyword(s):  
Tumour Necrosis Factor ◽  
Transferrin Receptor ◽  
Tumour Necrosis ◽  
Receptor Expression ◽  
Transferrin Receptors ◽  
Tumour Necrosis Factor Α ◽  
K 562 Cells ◽  
Factor Α ◽  
Transferrin Receptor Expression ◽  
Necrosis Factor

The effects of tumour necrosis factor-α on transferrin receptor expression in a human chronic myelocytic leukaemia cell line, K 562 cells, were studied. Cytofluorometry studies showed that the numbers of transferrin receptors in exponentially growing K 562 cells were increased when the cells were incubated with tumour necrosis factor-α for 24 h. The induction of transferrin receptors by tumour necrosis factor-α may be mediated by a mechanism that is independent of growth since cell growth in treated cultures did not differ from that in the controls. The DNA contents of K 562 cells treated with tumour necrosis factor-α showed that after 24 h there were less cells in the G1 and S phases and more cells in the G2/M phase than in the control group. The phase of upregulation of transferrin receptors induced by tumour necrosis factor-α may be dependent on the cell cycle. This new evidence that tumour necrosis factor-α upregulates transferrin receptors suggests a cancer-anaemia cascade in which the cancer burden state activates macrophage release of tumour necrosis factor-α as a result of transferrin receptor expression.

scholarly journals Retrovirus‐elicited interleukin‐12 and tumour necrosis factor‐α as inducers of interferon‐γ‐mediated pathology in mouse AIDS

Immunology ◽  
1996 ◽  
Vol 87 (3) ◽  
pp. 467-474 ◽  
Author(s):  
N. A. GIESE ◽  
R. T. GAZZINELLI ◽  
J. K. ACTOR ◽  
R. A. MORAWETZ ◽  
M. SARZOTTI ◽  
...  
Keyword(s):  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Interferon Γ ◽  
Interleukin 12 ◽  
Tumour Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor
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