Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes

1998 ◽  
Vol 3 (11) ◽  
pp. 751-763 ◽  
Author(s):  
Tadashi Anan ◽  
Yoichi Nagata ◽  
Hisashi Koga ◽  
Yoshiomi Honda ◽  
Nami Yabuki ◽  
...  
Keyword(s):  
Subcellular Localization ◽  
Ubiquitin Protein Ligase ◽  
Human Ubiquitin ◽  
Selective Interaction ◽  
Conjugating Enzymes ◽  
Ubiquitin Conjugating Enzymes

scholarly journals Identification of a Family of Closely Related Human Ubiquitin Conjugating Enzymes

1995 ◽  
Vol 270 (51) ◽  
pp. 30408-30414 ◽  
Author(s):  
Jane P. Jensen ◽  
Paul W. Bates ◽  
Mei Yang ◽  
Richard D. Vierstra ◽  
Allan M. Weissman
Keyword(s):  
Human Ubiquitin ◽  
Conjugating Enzymes ◽  
Ubiquitin Conjugating Enzymes

scholarly journals Glucose-Induced Monoubiquitination of the Saccharomyces cerevisiae Galactose Transporter Is Sufficient To Signal Its Internalization

2001 ◽  
Vol 183 (10) ◽  
pp. 3083-3088 ◽  
Author(s):  
Jaroslav Horak ◽  
Dieter H. Wolf
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Endocytic Pathway ◽  
Mutant Phenotype ◽  
Wild Type ◽  
Polyubiquitin Chains ◽  
Ubiquitin Protein Ligase ◽  
Essential Step ◽  
Conjugating Enzymes ◽  
Ubiquitin Conjugating Enzymes ◽  
Mutant Cells

ABSTRACT In Saccharomyces cerevisiae, the addition of glucose to cells growing on galactose induces internalization of the galactose transporter Gal2p and its subsequent proteolysis in the vacuole. Here we report that the essential step in Gal2p down-regulation is its ubiquitination through the Ubc1p-Ubc4p-Ubc5p triad of ubiquitin-conjugating enzymes and Npi1/Rsp5p ubiquitin-protein ligase. Moreover, Gal2p appears to be stabilized in mutant cells defective in the ubiquitin-hydrolase Npi2p/Doa4p, and the mutant phenotype can be reversed by overexpression of ubiquitin. An analysis of the fate of Gal2p in cells overexpressing wild-type ubiquitin as well as its variants incompetent to form polyubiquitin chains showed that monoubiquitination of Gal2p is sufficient to signal internalization of the protein into the endocytic pathway.

scholarly journals N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8

2001 ◽  
Vol 268 (9) ◽  
pp. 2725-2732 ◽  
Author(s):  
Kenichi Ito ◽  
Seiji Adachi ◽  
Reiko Iwakami ◽  
Hideyo Yasuda ◽  
Yoshinori Muto ◽  
...  
Keyword(s):  
Ring Finger ◽  
Human Ubiquitin ◽  
Conjugating Enzymes ◽  
Ring Finger Proteins ◽  
Ubiquitin Conjugating Enzymes

scholarly journals Cloning of Human Ubiquitin-conjugating Enzymes UbcH6 and UbcH7 (E2-F1) and Characterization of Their Interaction with E6-AP and RSP5

1996 ◽  
Vol 271 (5) ◽  
pp. 2795-2800 ◽  
Author(s):  
Ulrike Nuber ◽  
Sylvia Schwarz ◽  
Peter Kaiser ◽  
Rainer Schneider ◽  
Martin Scheffner
Keyword(s):  
Human Ubiquitin ◽  
Conjugating Enzymes ◽  
Ubiquitin Conjugating Enzymes
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