Alteration of PTEN expression in endometrial carcinoma is associated with down-regulation of cyclin-dependent kinase inhibitor, p27

2002 ◽  
Vol 41 (5) ◽  
pp. 437-445 ◽  
Author(s):  
H-J An ◽  
Y-H Lee ◽  
N-H Cho ◽  
J-Y Shim ◽  
J-Y Kim ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Kinase Inhibitor ◽  
Pten Expression ◽  
Cyclin Dependent Kinase ◽  
Down Regulation ◽  
Cyclin Dependent Kinase Inhibitor

scholarly journals Cyclin B Proteolysis and the Cyclin-dependent Kinase Inhibitor rum1p Are Required for Pheromone-induced G1 Arrest in Fission Yeast

1998 ◽  
Vol 9 (6) ◽  
pp. 1309-1321 ◽  
Author(s):  
Bodo Stern ◽  
Paul Nurse
Keyword(s):  
Fission Yeast ◽  
Kinase Activity ◽  
Kinase Inhibitor ◽  
Cyclin B ◽  
G1 Arrest ◽  
Cyclin Dependent Kinase ◽  
Down Regulation ◽  
Cyclin Dependent Kinase Inhibitor ◽  
Pheromone Signaling

The blocking of G1 progression by fission yeast pheromones requires inhibition of the cyclin-dependent kinase cdc2p associated with the B-cyclins cdc13p and cig2p. We show that cyclosome-mediated degradation of cdc13p and cig2p is necessary for down-regulation of B-cyclin–associated cdc2p kinase activity and for phermone-induced G1 arrest. The cyclin-dependent kinase inhibitor rum1p is also required to maintain this G1arrest; it binds both cdc13p and cig2p and is specifically required for cdc13p proteolysis. We propose that rum1p acts as an adaptor targeting cdc13p for degradation by the cyclosome. In contrast, the cig2p–cdc2p kinase can be down-regulated, and the cyclin cig2p can be proteolyzed independently of rum1p. We suggest that pheromone signaling inhibits the cig2p–cdc2p kinase, bringing about a transient G1arrest. As a consequence, rum1p levels increase, thus inhibiting and inducing proteolysis of the cdc13p–cdc2p kinase; this is necessary to maintain G1 arrest. We have also shown that pheromone-induced transcription occurs only in G1 and is independent of rum1p.

Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125

2012 ◽  
Vol 84 (5) ◽  
pp. 598-611 ◽  
Author(s):  
Simona Caporali ◽  
Ester Alvino ◽  
Lauretta Levati ◽  
Alessia I. Esposito ◽  
Marina Ciomei ◽  
...  
Keyword(s):  
Kinase Inhibitor ◽  
Cyclin Dependent Kinase ◽  
Down Regulation ◽  
Cyclin Dependent Kinase Inhibitor

scholarly journals Down-regulation of the cyclin-dependent kinase inhibitor p57 is mediated by Jab1/Csn5 in hepatocarcinogenesis

Hepatology ◽  
2016 ◽  
Vol 63 (3) ◽  
pp. 898-913 ◽  
Author(s):  
Hui Guo ◽  
Li Jing ◽  
Yangzi Cheng ◽  
Vassilis Atsaves ◽  
Yi Lv ◽  
...  
Keyword(s):  
Kinase Inhibitor ◽  
Cyclin Dependent Kinase ◽  
Down Regulation ◽  
Cyclin Dependent Kinase Inhibitor
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