Ixodes ricinus tick salivary gland extract inhibits IL-10 secretion and CD69 expression by mitogen-stimulated murine splenocytes and induces hyporesponsiveness in B lymphocytes

2003 ◽  
Vol 25 (1) ◽  
pp. 27-37 ◽  
Author(s):  
Sigrid Hannier ◽  
Janet Liversidge ◽  
Jerry M. Sternberg ◽  
Alan S. Bowman
Keyword(s):  
Salivary Gland ◽  
B Lymphocytes ◽  
Ixodes Ricinus ◽  
Salivary Gland Extract ◽  
Murine Splenocytes ◽  
Gland Extract ◽  
Ricinus Tick ◽  
Cd69 Expression

scholarly journals Dissociating effect of salivary gland extract from Ixodes ricinus on human fibroblasts: Potential impact on Borrelia transmission

2019 ◽  
Vol 10 (2) ◽  
pp. 433-441 ◽  
Author(s):  
Amandine Boeuf ◽  
Gilles Schnell ◽  
Quentin Bernard ◽  
Aurelie Kern ◽  
Benoît Westermann ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Ixodes Ricinus ◽  
Human Fibroblasts ◽  
Salivary Gland Extract ◽  
Gland Extract ◽  
Potential Impact

scholarly journals Tick Salivary Gland Extract Inhibits Killing ofBorrelia afzelii Spirochetes by Mouse Macrophages

2001 ◽  
Vol 69 (1) ◽  
pp. 575-578 ◽  
Author(s):  
Marie Kuthejlová ◽  
Jan Kopecký ◽  
Gabriela Štěpánová ◽  
Aleš Macela
Keyword(s):  
Nitric Oxide ◽  
Salivary Gland ◽  
Ixodes Ricinus ◽  
Inhibitory Effect ◽  
Salivary Gland Extract ◽  
Tick Saliva ◽  
Murine Macrophages ◽  
Gland Extract ◽  
Mouse Macrophages ◽  
Defense Molecules

ABSTRACT Salivary gland extract (SGE) from Ixodes ricinus ticks inhibited the killing of Borrelia afzelii spirochetes by murine macrophages. SGE also reduced the production of two major defense molecules of phagocytes, superoxide and nitric oxide. It is likely that the suppression of macrophage microbicidal mechanisms contributes to the inhibitory effect of tick saliva on the killing ofB. afzelii spirochetes, thus facilitating the transmission of this important pathogen.

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