scholarly journals Atherogenic concentrations of native low-density lipoproteins down-regulate nitric-oxide-synthase mRNA and protein levels in endothelial cells

1998 ◽  
Vol 252 (3) ◽  
pp. 378-384 ◽  
Author(s):  
Francisco Vidal ◽  
Cristina Colome ◽  
Jose Martinez-Gonzalez ◽  
Lina Badimon
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Nitric Oxide Synthase ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Protein Levels ◽  
Oxide Synthase

Effects of Aggrenox and aspirin on plasma endothelial nitric oxide synthase and oxidised low-density lipoproteins in patients after ischaemic stroke

2011 ◽  
Vol 105 (01) ◽  
pp. 81-87 ◽  
Author(s):  
Yanti Sani ◽  
Christian Eisert ◽  
Alex Schevchuck ◽  
Alan Fong ◽  
Dan Hanley ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Time Course ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Randomised Study ◽  
Post Stroke ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

SummaryPlasma endothelial nitric oxide synthase (eNOS), and oxidised low-density lipoproteins (oxLDL) are established biomarkers of atherosclerosis. We defined the time course and magnitude of changes of plasma eNOS and oxLDL after Aggrenox or aspirin in post-stroke patients. Baseline pretreatment eNOS levels were significantly diminished (110 ± 66pg /ml vs. 374 ± 88 pg/ml, p=0.0001), while oxLDL was twice higher (58 ± 9 mg/l vs. 23 ± 7 mg/l, p=0.004) in post-stroke survivors when compared to controls. Both Aggrenox and aspirin similarly increased plasma eNOS activity. However, oxLDL levels were static after aspirin, but inhibited late after Aggrenox. In the small randomised study, both aspirin and Aggrenox produced fast and sustained recovery of plasma eNOS levels, while only therapy with Aggrenox was associated with oxLDL inhibition late in the trial.

Diminished capacity to release metabolites of nitric oxide synthase in macrophages loaded with oxidized low-density lipoproteins

1992 ◽  
Vol 212 (1) ◽  
pp. 113-115 ◽  
Author(s):  
Philippe G. Jorens ◽  
Maryvonne Rosseneu ◽  
Anne-Marie Devreese ◽  
Hidde Bult ◽  
Bart Marescau ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Diminished Capacity ◽  
Oxidized Low Density Lipoproteins ◽  
Oxide Synthase

Interrelation between nitric oxide synthase and heme oxygenase in rat endothelial cells

1997 ◽  
Vol 331 (1) ◽  
pp. 87-91 ◽  
Author(s):  
Toshirou Seki ◽  
Mitsuhide Naruse ◽  
Kiyoko Naruse ◽  
Takanobu Yoshimoto ◽  
Akiyo Tanabe ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Nitric Oxide Synthase ◽  
Heme Oxygenase ◽  
Oxide Synthase
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