P139Transvaginal color Doppler study of uterine blood flow in primary dysmenorrhea

Abstract To determine effects of late gestational maternal nutrient restriction (NR) on uteroplacental blood flow and placental growth, primiparous fall-calving crossbred beef heifers [BW: 451 ± 28 (SD) kg; BCS: 5.4 ± 0.7] were individually-fed either 100% (control; CON; n = 12) or 70% (n = 13) of energy and protein requirements for maintenance, pregnancy, and growth during the last 120 days of gestation. Transrectal color Doppler ultrasonography of both uterine arteries was conducted pre-treatment and every 21 d during treatments. Placentas were split into ipsilateral and contralateral sides, dissected (cotyledonary vs. intercotyledonary), and dried. Data were analyzed with treatment, treatment initiation date, and calf sex (when P < 0.25) as fixed effects. Uterine blood flow included day and treatment x day (repeated measures). Dam BW was less (P ≤ 0.01) from d 223 of gestation through parturition for NR dams, but calf BW was not affected (P = 0.72) by treatment. The interaction affected (P < 0.01) heart rate, where NR dams had decreased heart rate after treatments began. Treatment did not affect (P ≥ 0.20) uterine artery blood flow or hemodynamics, but all variables were affected (P ≤ 0.04) by day. Contralateral total and cotyledonary weights tended (P ≤ 0.09) to be greater and ipsilateral and total cotyledonary:intercotyledonary ratios were greater (P ≤ 0.01) for CON. Cotyledon number, cotyledon size, and total cotyledonary, intercotyledonary, and placental weight were not affected (P ≥ 0.15) by treatment. Relative to dam BW, uterine blood flow was not affected (P = 0.83), but relative placental weight tended to be greater (P = 0.09) in NR dams. In the current study, NR dams lost maternal BW during late gestation and had less contralateral placental growth, yet uterine blood flow was maintained and placental size relative to BW ensured fetal growth similar to CON offspring.

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State of uterine blood flow in women of reproductive age with endometrial hyperplasia

HEALTH OF WOMAN ◽

10.15574/hw.2016.113.141 ◽

2016 ◽

pp. 141-143

Author(s):

V.G. Dubinina ◽

◽

K.M. Vizir ◽

Keyword(s):

Blood Flow ◽

Pulsatility Index ◽

Uterine Artery ◽

Endometrial Hyperplasia ◽

Color Doppler ◽

Reproductive Period ◽

Control Group ◽

Uterine Blood Flow ◽

Resistivity Index ◽

Significant Difference

The objective: to assess the state of uterine blood flow in endometrial hyperplasia in women of reproductive period. Patients and methods. 130 patients (n=100 – the main group; n=30 – control group) aged 18-49 years with endometrial hyperplasia were examined. All the women underwent 2D transvaginal echography and color Doppler mapping. The angle-independent indices (pulsatility index, resistivity index, diastolic/systolic ratio) of blood flow were determined in the uterine, arcuate, radial, basal and spiral arteries. Results. There was no significant difference in the indices of blood flow of the right uterine artery, arcuate, radial, basal arteries among patients and control group. Among women with endometrial hyperplasia pulsatility index of the left uterine artery amounted to – 2.11, resistivity index – 0.88, and the diastolic/systolic ratio – 5.45, in women of the control group – 2.34, 1.01 and 7.50, respectively. Only among patients with endometrial hyperplastic process was registered blood flow in the spiral arteries. Conclusion. The use of color Doppler mapping is appropriate, because registration of intraendometrial blood flow allows an endometrial hyperplastic process to be diagnosed with a high degree of confidence. Key words: endometrial hyperplasia, reproductive period, color Doppler mapping, intraendometrial blood flow, pulsatility index, resistivity index, diastolic/systolic ratio.

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