scholarly journals Changes in the Kinetics of Dopamine Release and Uptake Have Differential Effects on the Spatial Distribution of Extracellular Dopamine Concentration in Rat Striatum

2002 ◽  
Vol 74 (4) ◽  
pp. 1563-1573 ◽  
Author(s):  
Jennifer L. Peters ◽  
Adrian C. Michael
Keyword(s):  
Spatial Distribution ◽  
Dopamine Release ◽  
Rat Striatum ◽  
Dopamine Concentration ◽  
Differential Effects ◽  
Extracellular Dopamine ◽  
Kinetics Of

scholarly journals Kinetic features of the dopamine release and uptake in the dorsal and ventral striatum of rats

2020 ◽  
Vol 19 (4) ◽  
pp. 47-54
Author(s):  
Valery N. Mukhin ◽  
Ivan R. Borovets ◽  
Vadim V. Sizov ◽  
Konstantin I. Pavlov ◽  
Victor M. Klimenko
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Ventral Striatum ◽  
Dorsal Striatum ◽  
Principal Component ◽  
Dopamine Uptake ◽  
Rat Striatum ◽  
The Core ◽  
Kinetics Of

Kinetics of the evoked dopamine release and subsequent uptake in the parts of the rat striatum has not been studied sufficiently. The aim of this study is to fill this gap and to investigate kinetics of dopamine release and uptake in vivo so that comparison can be made between the dorsal and the parts of the ventral striatum and with taking into account the overlapping electrochemical factors during the subsequent analysis of voltammetry recordings. Materials and methods. The evoked wave of dopamine release and uptake in the dorsal striatum, core, and shell of the nucleus accumbens in the different groups of rats was recorded by the fast-scan cyclic voltammetry. Voltammetry recordings were subjected to principal component analysis and only the components associated with dopamine were taken for further analysis. The values of the parameters of the curves of dopamine release and uptake were defined. Then factor and variance analyses of the parameters were carried out. Results. Factor analysis showed that the set of parameters of the dopamine wave can be reduced to the 4 factors that are comparable with the variables of the known from the literature mathematical model that describes the dopamine wave based on the MichaelisMenten equation. Two of the factors and the corresponding parameters of the dopamine curve differ within the dorsal and ventral striatum. Factor 1 is associated with the parameters HL, T80_20, T20_0, slope_T20T0, which are significantly larger in the core of the nucleus accumbens. Factor 3 is associated with the parameters T50_2, AUC, FWHH, T100_80 which are significantly less in the dorsal striatum. Conclusions. The parameters of the curve of dopamine release and uptake are determined by 4 factors. Among the dopamine curve parameters, the best measures of the factors are T50_1, DAC, T100_80 и T20_0. The kinetics of stimulated dopamine release and uptake varies within the dorsal and ventral striatum. The final phase of dopamine uptake is slowed in the core of the nucleus accumbens in comparison to the shell, and the dorsal striatum. The slope of initial phase of dopamine uptake in the dorsal striatum is steeper.

Differential effects of amphetamine isomers on dopamine release in the rat striatum and nucleus accumbens core

2004 ◽  
Vol 178 (2-3) ◽  
pp. 250-258 ◽  
Author(s):  
Paul E. A. Glaser ◽  
Theresa C. Thomas ◽  
B. Matthew Joyce ◽  
F. Xavier Castellanos ◽  
Greg A. Gerhardt
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Rat Striatum ◽  
Nucleus Accumbens Core ◽  
Differential Effects ◽  
Accumbens Core

Long-term monitoring of extracellular dopamine concentration in the rat striatum by a repeated microdialysis procedure

1997 ◽  
Vol 72 (2) ◽  
pp. 123-135 ◽  
Author(s):  
Rémi Martin-Fardon ◽  
Françoise Sandillon ◽  
Jean Thibault ◽  
Alain Privat ◽  
Jacques Vignon
Keyword(s):  
Rat Striatum ◽  
Dopamine Concentration ◽  
Extracellular Dopamine ◽  
Long Term Monitoring ◽  
Term Monitoring

Differential Influence of Amyloid-β on the Kinetics of Dopamine Release in the Dorsal and Ventral Striatum of Rats

2021 ◽  
Author(s):  
Valery N. Mukhin ◽  
Ivan R. Borovets ◽  
Vadim V. Sizov ◽  
Konstantin I. Pavlov ◽  
Victor M. Klimenko
Keyword(s):  
Dopamine Release ◽  
Ventral Striatum ◽  
Amyloid Β ◽  
Kinetics Of

scholarly journals Transcranial direct-current stimulation increases extracellular dopamine levels in the rat striatum

2013 ◽  
Vol 7 ◽  
Author(s):  
Tomoko Tanaka ◽  
Yuji Takano ◽  
Satoshi Tanaka ◽  
Naoyuki Hironaka ◽  
Kazuto Kobayashi ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Rat Striatum ◽  
Direct Current Stimulation ◽  
Extracellular Dopamine

Glutamatergic Control of Dopamine Release in the Rat Striatum: Evidence for Presynaptic N-Methyl-D-Aspartate Receptors on Dopaminergic Nerve Terminals

1991 ◽  
Vol 56 (1) ◽  
pp. 81-85 ◽  
Author(s):  
M. O. Krebs ◽  
J. M. Desce ◽  
M. L. Kemel ◽  
C. Gauchy ◽  
G. Godeheu ◽  
...  
Keyword(s):  
Dopamine Release ◽  
Rat Striatum ◽  
Nerve Terminals
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