scholarly journals PEE7: A COST COMPARISON STUDY OF COMMON PRACTICE AND BEST PRACTICE TREATMENT FOR PRIMARY OPEN-ANGLE GLAUCOMA IN THE UNITED STATES

2001 ◽  
Vol 4 (2) ◽  
pp. 120-121
Author(s):  
SJ Evans ◽  
J Casciano ◽  
JJ Doyle ◽  
JG Walt
Cells ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 1518 ◽  
Author(s):  
Jennifer A. Faralli ◽  
Mark S. Filla ◽  
Donna M. Peters

Primary open angle glaucoma (POAG) is the most common form of glaucoma and the 2nd most common cause of irreversible vision loss in the United States. Nearly 67 million people have the disease worldwide including >3 million in the United States. A major risk factor for POAG is an elevation in intraocular pressure (IOP). The increase in IOP is believed to be caused by an increase in the deposition of extracellular matrix proteins, in particular fibronectin, in a region of the eye known as the trabecular meshwork (TM). How fibronectin contributes to the increase in IOP is not well understood. The increased density of fibronectin fibrils is thought to increase IOP by altering the compliance of the trabecular meshwork. Recent studies, however, also suggest that the composition and organization of fibronectin fibrils would affect IOP by changing the cell-matrix signaling events that control the functional properties of the cells in the trabecular meshwork. In this article, we will discuss how changes in the properties of fibronectin and fibronectin fibrils could contribute to the regulation of IOP.


Ophthalmology ◽  
2009 ◽  
Vol 116 (5) ◽  
pp. 823-832 ◽  
Author(s):  
David B. Rein ◽  
John S. Wittenborn ◽  
Paul P. Lee ◽  
Kathleen E. Wirth ◽  
Stephen W. Sorensen ◽  
...  

2013 ◽  
Vol 155 (2) ◽  
pp. 342-353.e5 ◽  
Author(s):  
Louis R. Pasquale ◽  
Stephanie J. Loomis ◽  
Jae H. Kang ◽  
Brian L. Yaspan ◽  
Wael Abdrabou ◽  
...  

1999 ◽  
Vol 2 (5) ◽  
pp. 351
Author(s):  
J Doyle ◽  
S Arikian ◽  
J Casciano ◽  
A Amsel ◽  
R Casciano

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