Pressure Drop, Shear Stress, and Activation of Leukocytes During Cardiopulmonary Bypass: A Comparison Between Hollow Fiber and Flat Sheet Membrane Oxygenators

2000 ◽  
Vol 24 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Y.J. Gu ◽  
P.W. Boonstra ◽  
R. Graaff ◽  
A.A. Rijnsburger ◽  
H. Mungroop ◽  
...  
1994 ◽  
Vol 17 (10) ◽  
pp. 543-548 ◽  
Author(s):  
Y.J. Gu ◽  
P.W. Boonstra ◽  
C. Akkerman ◽  
H. Mungroop ◽  
I. Tigchelaar ◽  
...  

The contact of blood with the artificial extracorporeal circuit causes a systemic inflammatory response due to blood activation. In this study, we compared two different paediatric membrane oxygenators used for extracorporeal circulation: a hollow fibre membrane oxygenator (Dideco Masterflo D-701, n=10), and a flat sheet silicone membrane oxygenator (Avecor Kolobow 800-2A, n=10). Blood compatibility was indicated by measuring complement activation as well as leukocyte and platelet activation. In patients perfused with a flat sheet membrane oxygenator, concentrations of complement split products C3a were significantly increased 30 minutes after the start of bypass (p<0.01), whereas only a mild increase of C3a was found in patients perfused with a hollow fibre membrane oxygenator. Leukocyte and platelet counts dropped uniformly in both groups after the start of bypass mainly due to hemodilution. Activation of leukocytes and platelets identified by both plasma β-glucuronidase and β-thromboglobulin was similar in both groups. Infants perfused with a flat sheet membrane oxygenator received significantly more donor blood than those perfused with a hollow fibre oxygenator (p<0.05). These results indicate that when used during paediatric cardiopulmonary bypass, a flat sheet membrane oxygenator has a higher complement activity than a hollow fibre membrane oxygenator, which is probably due to the relatively larger blood-surface contacting area of the oxygenator.


2001 ◽  
Author(s):  
Randal M. Wenthold

Abstract For years in the semiconductor inductor industry the only choice individuals had for microfiltration or ultrafiltration devices consisted of flat sheet membrane manufactured into spiral wound or pleated filtration products. Polysulfone hollow fiber technology has evolved in the medical device industry for use as the highest purity type filtration device available. This unique technology is now available for use in the semiconductor business segment as well with product offerings that may be used in laboratory to large-scale applications.


2013 ◽  
Vol 53 (7) ◽  
pp. 1744-1754 ◽  
Author(s):  
Tahir Majeed ◽  
Fezeh Lotfi ◽  
Sherub Phuntsho ◽  
Joon Khee Yoon ◽  
Kwonil Kim ◽  
...  

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