scholarly journals New drug delivery system in ophthalmology: results studying the surface structure of soft contact lenses from various polymer

2021 ◽  
Vol 40 ◽  
pp. 03002
Author(s):  
Elena Zhilyakova ◽  
Denis Naplekov ◽  
Anastasia Malyutina ◽  
Alexander Bondarev ◽  
Oleg Novikov
Keyword(s):  
Surface Structure ◽  
Large Scale ◽  
Contact Lenses ◽  
Absorption Capacity ◽  
Soft Contact ◽  
Force Microscopy ◽  
Soft Contact Lenses ◽  
Atomic Force ◽  
Medicinal Substances ◽  
Pore Properties

The development of an ophthalmic therapeutic system includes research on the spatial structure of soft contact lens polymers and the study of the processes of saturation and release of medicinal substances from them. This allows you to determine the methods of saturation of contact lenses with medicinal agents and will open up new opportunities in the treatment of ophthalmological diseases. The purpose of this preliminary fragment of large-scale research was to study the surface structure of soft contact lenses made of various polymers. The following polymers were used in the work: Nelfilcon A, Hilafilcon B, Nezofilcon A, Etafilcon A, Lotrafilcon B. The following pharmaceutical substances were used: Brimonidine Tartrate, Betaxolol Hydrochloride, Pyridoxine Hydrochloride. The surface structure of soft contact lenses was studied using atomic force microscopy. Each material under study has a different surface character, which together with the differences in pore properties determines its individuality. Based on this, it should be assumed that the surface of soft contact lenses affects the possibility of their potential use as a means of delivering drug agent molecules to the eye tissues. In all cases of soft contact saturation, the highest absorption capacity was demonstrated by Hilafilcon B and Etafilcon A with a similar surface.

Microscopic observation of unworn siloxane-hydrogel soft contact lenses by atomic force microscopy

2006 ◽  
Vol 76B (2) ◽  
pp. 412-418 ◽  
Author(s):  
José M. González-Méijome ◽  
Antonio López-Alemany ◽  
José B. Almeida ◽  
Manuel A. Parafita ◽  
Miguel F. Refojo
Keyword(s):  
Atomic Force Microscopy ◽  
Microscopic Observation ◽  
Contact Lenses ◽  
Soft Contact ◽  
Force Microscopy ◽  
Soft Contact Lenses ◽  
Atomic Force

scholarly journals ToF-SIMS and AFM Characterization of Brown Cosmetic Contact Lenses: From Structural Analysis to the Identification of Pigments

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Seon Hee Kim ◽  
Jihye Lee ◽  
Yun Jung Jang ◽  
Kang-Bong Lee ◽  
Yeonhee Lee
Keyword(s):  
Secondary Ion Mass Spectrometry ◽  
Contact Lenses ◽  
Analytical Techniques ◽  
Pigment Layer ◽  
Force Microscopy ◽  
Soft Contact Lenses ◽  
Atomic Force ◽  
Tof Sims ◽  
The Cross ◽  
Specific Fragment

Over the years, soft contact lenses for vision correction and cosmetic and therapeutic purposes have been greatly improved. For cosmetic contact lenses, the pigments need to be nontoxic, and the position of the pigment layer is particularly important because of the risks posed by pigment elution and the roughness of the lens surface. In this paper, we characterized the properties of brown cosmetic contact lenses made by three different manufacturers using surface analytical techniques. The surface topographies of the noncolored and colored parts were obtained by atomic force microscopy (AFM), and the position and composition of the pigment layer were determined by analyzing the cross section of the contact lenses using scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDX). The influence of pigment location on surface roughness was also examined. In addition, to find the method of the evaluation for the risk of surface elution of the pigments in the colored parts, the mass spectra and ion images of the surfaces were obtained by time-of-flight secondary ion mass spectrometry (ToF-SIMS) with a new sample preparation. From the ToF-SIMS spectra, we observed specific fragment ions of the poly(hydroxyethyl methacrylate) (PHEMA) polymer and found differences in the composition of the pigment layer depending on the manufacturers. The cross-sectioned image and 3D chemical characterizations of metallic and specific ions in the brown cosmetic contact lenses clearly indicated the spatial distribution and location of the pigment layer that can be used for the evaluation of pigment elution.

Peculiarities of cultivation of the monolayer of fetal fibroblasts on the soft contact lenses, with contain the collagen

2009 ◽  
Vol 21 (5) ◽  
pp. 46-50
Author(s):  
N. Pasechnikova ◽  
◽  
G. Drozhzhina ◽  
O. Ivanova ◽  
I. Nasinnik ◽  
...  
Keyword(s):  
Contact Lenses ◽  
Soft Contact ◽  
Soft Contact Lenses ◽  
Fetal Fibroblasts

Modification of therapeutic silicone-hydrogel soft contact lenses

2016 ◽  
Vol 16 (3) ◽  
pp. 117-120 ◽  
Author(s):  
T.N. Safonova ◽  
◽  
I.A. Novikov ◽  
V.I. Boev ◽  
O.V. Gladkova ◽  
...  
Keyword(s):  
Contact Lenses ◽  
Soft Contact ◽  
Silicone Hydrogel ◽  
Soft Contact Lenses

scholarly journals Myopia Control with Combination Low-Dose Atropine and Peripheral Defocus Soft Contact Lenses: A Case Series

2021 ◽  
pp. 548-554
Author(s):  
Nir Erdinest ◽  
Naomi London ◽  
Nadav Levinger ◽  
Yair Morad
Keyword(s):  
Low Dose ◽  
Contact Lenses ◽  
Case Series ◽  
Concentric Circle ◽  
Retrospective Case ◽  
Soft Contact ◽  
Myopia Progression ◽  
Soft Contact Lenses ◽  
Center Distance ◽  
Myopia Control

The goal of this retrospective case series is to demonstrate the effectivity of combination low-dose atropine therapy with peripheral defocus, double concentric circle design with a center distance soft contact lenses at controlling myopia progression over 1 year of treatment. Included in this series are 3 female children aged 8–10 years with progressing myopia averaging −4.37 ± 0.88 D at the beginning of treatment. Their average annual myopic progression during the 3 years prior to therapy was 1.12 ± 0.75 D. They had not attempted any myopia control treatments prior to this therapy. The children were treated with a combination of 0.01% atropine therapy with spherical peripheral defocus daily replacement soft lenses MiSight<sup>®</sup> 1 day (Cooper Vision, Phoenix, AZ, USA). They underwent cycloplegic refraction, and a slit-lamp evaluation every 6 months which confirmed no adverse reactions or staining was present. Each of the 3 children exhibited an average of 0.25 ± 0.25 D of myopia progression at the end of 1 year of treatment. To the best of the authors’ knowledge, this is the first published study exhibiting that combining low-dose atropine and peripheral defocus soft contact lenses is effective at controlling children’s moderate to severe myopia progression during 1 year of therapy.

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