An EPR study of the radicals issued from nitrocatechols and nitrohydroquinone: a new method of production of nitroaromatic anion radicals

1995 ◽  
Vol 92 ◽  
pp. 97-103 ◽  
Author(s):  
JL Grenier ◽  
P Cotelle ◽  
N Cotelle ◽  
JP Catteau
2021 ◽  
pp. 205-214
Author(s):  
Juan Ramón Rallo

One of the entrepreneurial strategies that, according to Schumpeter, is responsible for the capitalistic process of Creative Destruction is the introduction of a new method of production (Schumpeter 2003, 83). Austrian economics characterizes a «method of production» as a set of capital goods and original factors of production inserted into an entrepreneurial plan, which is directed to satisfy consumer needs. Therefore, we could say that capital goods do not work in isolation, but as parts of two structures: they develop a role in the individual plan of the entrepreneur and also in the spontaneous social order that unintentionally results from the coordination of the different entrepreneurial plans. In this context, the introduction of a new method of production implies that at least one entrepreneur tries to modify his plan either by rearranging his combination of capital goods and original factors of production (due to a change in consumer preferences or due to the appearance of some new technology) or by using new capital goods or new original factors of production (due to the discovery of a new technology or due to an increase in savings). Thus, both cases require the entrepreneur to disrupt not only his previous plan, but also the existing links with other plans in the incumbent capital structure. This obviously raises the question of whether these disruptions lead to a progressive and sustained capital accumulation or if, on the contrary, they cause a necessary destruction of some capital goods. At least since Cantillon and Turgot economists have taught that progress and growth depend partially on the quantity of capital, which tends to increase gradually with the level of savings. However, Schumpeter’s claim —that the introduction of a new method of production implies a Creative Destruction process— seems to suggest that some capital will be lost with the new investments. We would have, on the one hand, more capital by means of the creation of new plans but, on the other, less capital because of the disruption of the existing plans. Although this approach may be initially shocking, only by departing from the erroneous idea that all capital goods are homogeneous one could consistently claim that new methods of production do not destroy any capital at all, i.e., only supposing that capital goods combinations and structures are irrelevant in relation to their final output, the view of a non-disturbable capital accumulation could be held. Once heterogeneity of capital goods comes into the picture, it is no longer possible to believe in such a hypothesis.


2006 ◽  
Vol 256 (1-2) ◽  
pp. 37-42 ◽  
Author(s):  
Yuuji Shimasaki ◽  
Kimio Ariyoshi ◽  
Hideyuki Kambe ◽  
Hitoshi Yano ◽  
Shukichi Ugamura

2021 ◽  
Vol 23 (1) ◽  
pp. 120-125
Author(s):  
O. Yu. Isaienko ◽  
O. V. Kotsar ◽  
T. M. Ryzhkova ◽  
H. I. Diukareva

The aim of the work – to produce metabolic complexes with significant antibacterial properties using a new proprietary method and to substantiate the prospects of their use for designing of antimicrobial polyfunctional drugs. Materials and methods. Metabolic complexes of Lactobacillus rhamnosus GG, Lactobacillus plantarum, Saccharomyces boulardii, Enterococcus faecium were obtained by culturing the producers in ultrasonic disintegrates of other probiotic microorganisms. Sensitivity of antibiotic-resistant strains of Escherichia coli PR and Staphylococcus haemolyticus PR was determined by qualitative method. The suspension of test-cultures (optical density of 1.0 units on the McFarland scale) after incubation with metabolites (2, 24 and 48 hours at 37 °C) was inoculated into Mueller–Hinton agar. The absence of growth was indicative of the metabolic complexes antibacterial activity against the microorganism. Results. Cultivation of S. boulardii in the S. boulardii / L. rhamnosus / L. plantarum / E. faecium disintegrates, L. plantarum – in the L. rhamnosus / E. faecium disintegrates and L. rhamnosus – in the L. plantarum disintegrates was accompanied by an increase in the biomass of isolated microorganisms (P ≤ 0.03) and production of metabolites. Along with a similar increase in S. boulardii cells in the S. boulardii / L. rhamnosus / L. plantarum / E. faecium disintegrates, the metabolic products of lactobacterial and enterococcal disintegrates exhibited more active inhibitory effects against E. coli PR and S. haemolyticus PR. The increased antibacterial activity indicates the advantage of the new method. Another improvement is the extended spectrum of metabolic complexes owing to producer cultivation in the other probiotic disintegrates to obtain original biologically active substances with high antibacterial properties against pathogens. Among the strength of the method is that all the stages are unified into a single process avoiding multiphase procedure for the separate preparation of one probiotic microorganism disintegrate and the metabolic products of another. Conclusions. Disintegrates as a nutrient medium can be used not only for their own producers, but also for other strains/species and various probiotic microorganisms (fungi and bacteria). The increase in antibacterial activity of metabolic complexes has been found using the new method of production. The prospects of antimicrobial polyfunctional drugs designing on this basis have been proved.


1959 ◽  
Vol 14 (11) ◽  
pp. 969-971
Author(s):  
Yoshio SAWAI ◽  
Susumu IMAMURA ◽  
Kyunosuke KURIBAYASHI ◽  
Mitsuo KAMETA ◽  
Shutaro YAMAMOTO ◽  
...  

Author(s):  
C. C. Clawson ◽  
L. W. Anderson ◽  
R. A. Good

Investigations which require electron microscope examination of a few specific areas of non-homogeneous tissues make random sampling of small blocks an inefficient and unrewarding procedure. Therefore, several investigators have devised methods which allow obtaining sample blocks for electron microscopy from region of tissue previously identified by light microscopy of present here techniques which make possible: 1) sampling tissue for electron microscopy from selected areas previously identified by light microscopy of relatively large pieces of tissue; 2) dehydration and embedding large numbers of individually identified blocks while keeping each one separate; 3) a new method of maintaining specific orientation of blocks during embedding; 4) special light microscopic staining or fluorescent procedures and electron microscopy on immediately adjacent small areas of tissue.


1960 ◽  
Vol 23 ◽  
pp. 227-232 ◽  
Author(s):  
P WEST ◽  
G LYLES
Keyword(s):  

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