Leg blood flow and long-term cardiovascular prognosis in men with typical and atypical intermittent claudication

Patients with intermittent claudication frequently have high-normal levels of haematocrit and hence blood viscosity, which may contribute to decreased calf blood flow on exercise, and hence to the symptom of claudication. Reduction in haematocrit and viscosity by serial venesection in eight patients with stable claudication and high-normal haematocrit (mean 0.50) was performed, and the effects on claudication, calf blood flow, and calf oxygen delivery were studied. Following reduction in haematocrit to low-normal levels (mean 0.44), resting calf blood flow was unchanged; peak flow after ischaemic exercise increased slightly (+17%), but peak oxygen delivery (peak flow × haemoglobin concentration) was unchanged. Hence any increase in calf blood flow in the symptomatic leg is balanced by a decrease in oxygen-carrying capacity after venesection. No increase in claudication time would therefore be expected, and none was observed in the present study.

Download Full-text

The Effect of β-Blockade on Leg Blood Flow in Hypertensive Patients with Intermittent Claudication

Angiology ◽

10.1177/000331978603700302 ◽

1986 ◽

Vol 37 (3) ◽

pp. 149-153 ◽

Cited By ~ 8

Author(s):

Per-Åke Boström ◽

Lars Janzon ◽

Ola Ohlsson ◽

Anita Westergren

Keyword(s):

Blood Flow ◽

Intermittent Claudication ◽

Hypertensive Patients ◽

Leg Blood Flow

Download Full-text

Effect of Long-Term Anti-Hypertensive β-Receptor-Blocking Treatment on Haemodynamic and Metabolic Responses to Prolonged Exercise in Man

Clinical Science ◽

10.1042/cs051489s ◽

1976 ◽

Vol 51 (s3) ◽

pp. 489s-491s

Author(s):

M. Frisk-Holmberg ◽

A. Juhlin-Dannfeldt ◽

L. Jorfeldt ◽

H. Åström

Keyword(s):

Blood Flow ◽

Prolonged Exercise ◽

Plasma Concentrations ◽

Receptor Blocking ◽

Leg Blood Flow ◽

Drug Plasma Concentrations ◽

Drug Plasma ◽

Long Term Treatment ◽

Β Receptor

1. Central and regional haemodynamics and leg metabolism at rest, during and after a prolonged exercise were studied in seven untreated hypertensive males before and after a long-term treatment (6 weeks) with an unselective β-receptor-blocking drug (alprenolol). 2. Alprenolol treatment (200–400 mg, twice daily) decreased arterial blood pressure at rest and during exercise; it reduced heart rate in relation to drug plasma concentrations during and after exercise; it left cardiac output unchanged; it reduced leg blood flow at rest, but had no effect on leg blood flow during exercise. 3. Alprenolol treatment also decreased lipolysis and lactate release in relation to drug plasma concentrations during exercise.

Download Full-text

INCREASE IN LEG BLOOD-FLOW BY NORMOVOLqMIC HqMODDLUTION IN INTERMITTENT CLAUDICATION

The Lancet ◽

10.1016/s0140-6736(79)91433-8 ◽

1979 ◽

Vol 314 (8135) ◽

pp. 166-168 ◽

Cited By ~ 60

Author(s):

C YATES

Keyword(s):

Blood Flow ◽

Intermittent Claudication ◽

Leg Blood Flow

Download Full-text

Leg Blood Flow in Intermittent Claudication — A Comparison Between Non Insulin Dependent Diabetics and Non Diabetics

Angiology ◽

10.1177/000331978403501106 ◽

1984 ◽

Vol 35 (11) ◽

pp. 724-728 ◽

Cited By ~ 4

Author(s):

Lars Janzon ◽

Sven-Erik Bergentz ◽

Björn F. Ericsson ◽

Martin Hanson ◽

Sven-Eric Lindell

Keyword(s):

Blood Flow ◽

Intermittent Claudication ◽

Leg Blood Flow ◽

Insulin Dependent

Download Full-text

Ventilatory threshold is related to walking tolerance in patients with intermittent claudication

VASA ◽

10.1024/0301-1526/a000203 ◽

2012 ◽

Vol 41 (4) ◽

pp. 275-281 ◽

Cited By ~ 3

Author(s):

da Rocha Chehuen ◽

G. Cucato ◽

P. dos Anjos Souza Barbosa ◽

A. R. Costa ◽

M. Ritti-Dias ◽

...

Keyword(s):

Blood Flow ◽

Oxygen Uptake ◽

Intermittent Claudication ◽

Lower Limb ◽

Ventilatory Threshold ◽

Reactive Hyperemia ◽

Ankle Brachial Index ◽

Metabolic Parameters ◽

Walking Distance ◽

The Relationship

Background: This study assessed the relationship between lower limb hemodynamics and metabolic parameters with walking tolerance in patients with intermittent claudication (IC). Patients and methods: Resting ankle-brachial index (ABI), baseline blood flow (BF), BF response to reactive hyperemia (BFRH), oxygen uptake (VO2), initial claudication distance (ICD) and total walking distance (TWD) were measured in 28 IC patients. Pearson and Spearman correlations were calculated. Results: ABI, baseline BF and BF response to RH did not correlate with ICD or TWD. VO2 at first ventilatory threshold and VO2peak were significantly and positively correlated with ICD (r = 0.41 and 0.54, respectively) and TWD (r = 0.65 and 0.71, respectively). Conclusions: VO2peak and VO2 at first ventilatory threshold, but not ABI, baseline BF and BFHR were associated with walking tolerance in IC patients. These results suggest that VO2 at first ventilatory threshold may be useful to evaluate walking tolerance and improvements in IC patients.

Download Full-text