Insulin Resistance and Response to Telaprevir Plus Pegylated Interferon and Ribavirin: A Requiem for the HOMA Score?

2012 ◽  
Vol 143 (6) ◽  
pp. 1685-1687
Author(s):  
Alessio Aghemo ◽  
Massimo Colombo
Keyword(s):  
Insulin Resistance ◽  
Pegylated Interferon ◽  
Homa Score

scholarly journals Acculturation and Insulin Resistance Among US Chinese Immigrant Women

2015 ◽  
Vol 25 (4) ◽  
pp. 443 ◽  
Author(s):  
Marilyn Tseng ◽  
Carolyn Y. Fang
Keyword(s):  
Insulin Resistance ◽  
Repeated Measures ◽  
Disease Risk ◽  
Immigrant Women ◽  
Chinese Immigrants ◽  
Chinese Immigrant ◽  
Level Of Education ◽  
Chronic Disease Risk ◽  
Chinese Immigrant Women ◽  
Homa Score

<p class="Pa7"><strong>Objective: </strong>Chinese immigrants in the Unit­ed States undergo a transition to increased chronic disease risk commonly attributed to acculturative changes. Longitudinal data to confirm this are lacking. We examined acculturation in relation to insulin resistance in a sample of Chinese immigrant women to determine differences by level of education and possible mediation by anthropometry and diet.</p><p class="Pa7"><strong>Design: </strong>Longitudinal study.</p><p class="Pa7"><strong>Setting</strong><em>: </em>Philadelphia, Pennsylvania.</p><p class="Pa7"><strong>Participants: </strong>305 Chinese immigrant women recruited October 2005 to April 2008 and followed until April 2010.</p><p class="Pa7"><strong>Main Outcome Measures</strong><em>: </em>Association of acculturation, measured using the General Ethnicity Questionnaire – American version (GEQA), with homeostasis model assess­ment (HOMA) score as an indicator of insulin resistance, modeled using general­ized estimating equations to account for repeated measures over time.</p><p class="Pa7"><strong>Results: </strong>GEQA was associated with log HOMA score, but only in women with &lt;9 years of education (beta [SE] = .09 [.04], <em>P</em>=.02; interaction <em>P</em>=.02). The association persisted with adjustment for body mass index, waist circumference, and dietary variables.</p><p><strong>Conclusions: </strong>These findings provide longitudinal evidence that insulin resistance increases with acculturation. However, the association was apparent only in less-edu­cated immigrants and may be mediated by a pathway other than changes in anthropom­etry and diet. <em>Ethn Dis. </em>2015;25(4):443-450; doi:10.18865/ed.25.4.443</p>

Change of Insulin Resistance in Hepatitis C Virus-infected Patients Receiving Pegylated Interferon Plus Ribavirin

2015 ◽  
Vol 13 (7) ◽  
pp. e117
Author(s):  
Cheng-Hao Tseng ◽  
Yao-Chun Hsu ◽  
Chi-Yang Chang ◽  
Chih-Wen Lin ◽  
Jaw-Town Lin ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Pegylated Interferon ◽  
Pegylated Interferon Plus Ribavirin

Insulin resistance is not a relevant predictor of sustained virological response to pegylated interferon plus ribavirin in HIV/HCV co-infected patients

2009 ◽  
Vol 50 (4) ◽  
pp. 684-692 ◽  
Author(s):  
Nicolás Merchante ◽  
Ignacio de los Santos-Gil ◽  
Dolores Merino ◽  
Mercedes González-Serrano ◽  
José A. Mira ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Sustained Virological Response ◽  
Virological Response ◽  
Pegylated Interferon ◽  
Pegylated Interferon Plus Ribavirin

scholarly journals Influence of pegylated interferon and ribavirin on insulin resistance and metabolic factors in chronic hepatitis C

2018 ◽  
Vol 44 (2) ◽  
pp. 170-176
Author(s):  
Zeynep Altın ◽  
Gülden Diniz ◽  
Ayfer Çolak ◽  
Betül Koyuncu ◽  
Serhat Özer ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Serum Insulin ◽  
Pegylated Interferon ◽  
Hcv Rna ◽  
Model Assessment ◽  
Metabolic Factors ◽  
Significant Difference

Abstract Background In this study it was aimed to evaluate the effect of pegylated interferon alfa-2a/2b and ribavirin, which are used for treatment of chronic hepatitis C (CHC), on insulin resistance and metabolic factors. Materials and methods A total of 104 CHC patients aged 20–75 years with available serum insulin data at 0 and 48 weeks, and hepatitis C virus (HCV)-RNA data at 0, 12, 24, 48 and 72 weeks were included in the study. All clinical para-meters were assessed according to the therapy response. Results Among 104 patients, sustained virologic response (SVR) was achieved in 55 cases. A statistically significant difference was noted between SVR and non-SVR groups regarding γ-glutamyltranspeptidase (GGT), insulin level plus homeostasis model assessment (HOMA) score and insulin resistance at week 48, log HCV-RNA and stage of fibrosis. Conclusion Insulin resistance is accepted to have a negative effect on SVR. Insulin resistance may improve once SVR is achieved. Presence of IR at week 48 has been found associated with SVR. In this context, it can be advocated that insulin resistance at week 48 may be a predictive factor for prediction of SVR at week 72.

Sign in / Sign up

Export Citation Format

Share Document