Tricuspid Regurgitation in Congestive Heart Failure: Management Strategies and Analysis of Outcomes

Author(s):  
Geoffrey C. Ramsdell ◽  
James A. Nelson ◽  
Sorin V. Pislaru ◽  
Harish Ramakrishna
Heart ◽  
2019 ◽  
Vol 105 (23) ◽  
pp. 1813-1817 ◽  
Author(s):  
Amer N Kadri ◽  
Vivek Menon ◽  
Yasser M Sammour ◽  
Rama D Gajulapalli ◽  
Chandramohan Meenakshisundaram ◽  
...  

ObjectivesA substantial number of patients with severe tricuspid regurgitation (TR) and congestive heart failure (CHF) are medically managed without undergoing corrective surgery. We sought to assess the characteristics and outcomes of CHF patients who underwent tricuspid valve surgery (TVS), compared with those who did not.MethodsRetrospective observational study involving 2556 consecutive patients with severe TR from the Cleveland Clinic Echocardiographic Database. Cardiac transplant patients or those without CHF were excluded. Survival difference between patients who were medically managed versus those who underwent TVS was compared using Kaplan-Meier survival curves. Multivariate analysis was performed to identify variables associated with poor outcomes.ResultsAmong a total of 534 patients with severe TR and CHF, only 55 (10.3%) patients underwent TVS. Among the non-surgical patients (n=479), 30% (n=143) had an identifiable indication for TVS. At 38 months, patients who underwent TVS had better survival than those who were medically managed (62% vs 35%; p<0.001). On multivariate analysis, advancing age (HR: 1.23; 95% CI 1.12 to 1.35 per 10-year increase in age), moderate (HR: 1.39; 95% CI 1.01 to 1.90) and severe (HR: 2; 95% CI 1.40 to 2.80) right ventricular dysfunction were associated with higher mortality. TVS was associated with lower mortality (HR: 0.44; 95% CI 0.27 to 0.71).ConclusionAlthough corrective TVS is associated with better outcomes in patients with severe TR and CHF, a substantial number of them continue to be medically managed. However, since the reasons for patients not being referred to surgery could not be ascertained, further randomised studies are needed to validate our findings before clinicians can consider surgical referral for these patients.


2017 ◽  
Vol 11 (10) ◽  
pp. 271-278 ◽  
Author(s):  
Niel Shah ◽  
Raef Madanieh ◽  
Mehmet Alkan ◽  
Muhammad U. Dogar ◽  
Constantine E. Kosmas ◽  
...  

Chronic congestive heart failure (CHF) is a complex disorder characterized by inability of the heart to keep up the demands on it, followed by the progressive pump failure and fluid accumulation. Although the loop diuretics are widely used in heart failure (HF) patients, both pharmacodynamic and pharmacokinetic alterations are thought to be responsible for diuretic resistance in these patients. Strategies to overcome diuretic resistance include sodium intake restriction, changes in diuretic dose and route of administration and sequential nephron diuretic therapy. In this review, we discuss the definition, prevalence, mechanism of development and management strategies of diuretic resistance in HF patients.


2003 ◽  
Vol 31 (6) ◽  
pp. 475-480
Author(s):  
K Kusaka ◽  
T Takahashi ◽  
N Kotajima ◽  
K Sekiguchi ◽  
Y Fukumura ◽  
...  

2003 ◽  
Vol 5 (3) ◽  
pp. 371-380 ◽  
Author(s):  
S.P. Wright ◽  
H. Walsh ◽  
K.M. Ingley ◽  
S.A. Muncaster ◽  
G.D. Gamble ◽  
...  

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