Background and Importance: Angiographic-proven and clinically-evident cerebral vasospasm (CVS)
after uneventful elective clipping of unruptured intracranial aneurysm (UIA) is a very rare and often
underestimated event. To date, the knowledge of risk factors, pathophysiology, and demographic
characteristics of these conditions are solely relegated to few case reports. With the aim of better characterize
shared features and mechanism that could be involved in such event we also performed a review of the
present literature and analyzed aneurysm’s features, surgical factors, treatments, recovery and of all reported
cases of CVS after elective clipping.
Clinical Presentation: We report a case of a cerebral vasospasm following elective clipping of a middle
cerebral artery (MCA) bifurcation aneurysm in a 59-year-old woman who smoked next days after treatment,
despite medical advice. We found ten cases comparable to ours with angiographic-proven and clinically
evident cerebral vasospasm after uneventful elective clipping.
Conclusion: Classic mechanisms of CVS following SAH have been widely studied. In all the cases we
analyzed, no subarachnoid bleeding occurred, as demonstrated in pre and postoperative CT scans and
intraoperatively. Various theories on the possible mechanism have been advanced. It seems reasonable that
CVS following elective clipping of unruptured aneurysm is a multifactorial phenomenon. Although its
pathogenesis is unclear, clinicians should keep in mind the existence of this event, that is rare, but it could
be seen in the clinical practice of every neurosurgery ward. In our opinion, it’s worth to know this possible
post-operative complication because, when suspected clinical signs and symptoms of delayed ischemic
neurological deficit (DIND) arise after elective clipping, it’s important to make an early diagnosis of CVS
owing to early treatments are critical to improve clinical outcome
CEREBRAL VASOSPASM AND UNRUPTURED ANEURYSM IN THUNDERCLAP HEADACHE