Protective effect of S-adenosyl-?-methionine on bromobenzene- and ?- galactosamine-induced toxicity to isolated rat hepatocytes

Hepatology ◽  
1996 ◽  
Vol 23 (2) ◽  
pp. 359-365 ◽  
Author(s):  
J Wu
Keyword(s):  
Protective Effect ◽  
Rat Hepatocytes ◽  
Isolated Rat Hepatocytes ◽  
Adenosyl Methionine ◽  
Isolated Rat

scholarly journals Protective effect of metallothionein on cadmium toxicity in isolated rat hepatocytes

1985 ◽  
Vol 230 (2) ◽  
pp. 395-402 ◽  
Author(s):  
W S Din ◽  
J M Frazier
Keyword(s):  
Protective Effect ◽  
Cadmium Toxicity ◽  
Membrane Damage ◽  
Rat Hepatocytes ◽  
Protective Effects ◽  
Isolated Rat Hepatocytes ◽  
Detoxification Mechanism ◽  
Isolated Rat

An isolated rat hepatocyte preparation was used to study the cellular toxicity of cadmium and the protective effects of metallothionein on cadmium-induced toxicity. Exposure of primary suspension cultures of isolated rat hepatocytes to Cd2+ (0-35.7 microM) for 15 min resulted in a dose-dependent reduction in the synthesis of cellular proteins during a subsequent 6 h incubation. Such inhibition could not be correlated with cellular lethality or gross membrane damage. Pre-induction of metallothionein in hepatocytes by zinc treatment in vivo of donor rats protected hepatocytes in vitro from cadmium-induced inhibition of protein synthesis. The protective effects in zinc-pre-induced hepatocytes are not due to alterations in the level of total cellular cadmium, but could be accounted for by the redistribution of intracellular cadmium in the presence of high levels of zinc-metallothionein. The data suggest that metallothionein exerts its protective effect by a kinetic detoxification mechanism, i.e. a decrease in reactive intracellular cadmium.

Protective Effect of Green Tea Extract and Tea Polyphenols against the Cytotoxicity of 1,4-Naphthoquinone in Isolated Rat Hepatocytes

1997 ◽  
Vol 61 (11) ◽  
pp. 1901-1905 ◽  
Author(s):  
Chika Miyagawa ◽  
Chen Wu ◽  
David Opare Kennedy ◽  
Teruyo Nakatani ◽  
Kimiko Ohtani ◽  
...  
Keyword(s):  
Protective Effect ◽  
Green Tea ◽  
Rat Hepatocytes ◽  
Green Tea Extract ◽  
Tea Polyphenols ◽  
Isolated Rat Hepatocytes ◽  
Tea Extract ◽  
Isolated Rat

Protective effect of nitric oxide on isolated rat hepatocytes submitted to an oxidative stress

Metabolism ◽  
2002 ◽  
Vol 51 (2) ◽  
pp. 175-179 ◽  
Author(s):  
Aur[eacute]lie-Anne Chausse ◽  
Val[eacute]rie Nivet-Antoine ◽  
Chantal Martin ◽  
Jean-Pierre Clot ◽  
Fran[ccedil]ois-Xavier Galen
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Protective Effect ◽  
Rat Hepatocytes ◽  
Isolated Rat Hepatocytes ◽  
Isolated Rat
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