scholarly journals Recurrent Blood Pressure Rise after Treatment with Anti-vascular Endothelial Growth Factor Agents

2020 ◽  
Vol 237 (04) ◽  
pp. 454-457
Author(s):  
Iris Wyssmüller ◽  
Karen Schaal ◽  
Sebastian Wolf ◽  
Martin Zinkernagel
Keyword(s):  
Blood Pressure ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Pressure Increase ◽  
Vascular Endothelial ◽  
Blood Pressure Increase ◽  
Injection Process ◽  
Endothelial Growth Factor

Abstract Background It has previously been shown that the process of anti-vascular endothelial growth factor (VEGF) injections can lead to a significant increase of blood pressure. The aim of this study was to investigate whether this blood pressure increase was reproducible with repeated anti-VEGF injections. Patients and Methods Patients with a systolic blood pressure of ≥ 180 mmHg during previous injections who were scheduled for further injections were asked to participate in this study. Systolic as well as diastolic blood pressure was measured before, during, and after the intravitreal injection process. Results Thirty-nine patients (21 females, 18 males) with a mean age of 75 years (range 34 – 94 years) were included in this extension of the FEAR study. At first, clinical systolic blood pressure rose from an average of 157.3 ± 5.9 mmHg to 175 ± 6.7 mmHg at the time of the injection process (p < 0.01). Diastolic blood pressure rose from an average of 75.72 ± 4.2 mmHg to 84.44 ± 7.3 mmHg (p < 0.13) at the time of the injection process. Overall, the majority of the participants (56%, N = 22) had a systolic blood pressure of ≥ 180 mmHg. Conclusions Our results show that the blood pressure increase occurs persistently during the injection process in some patients. Repeated episodes of severe hypertension may predispose patients to cardiovascular events, especially those with concomitant cardiovascular risk factors.

P0590ADVERSE RENAL OUTCOME FOLLOWING ADMINISTRATION OF INTRAVITREAL ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR INHIBITORS IN A SINGLE TERTIARY CENTRE IN MALAYSIA

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Maisarah Jalalonmuhali ◽  
Tengku Ain Fathlun Tengku Kamalden ◽  
Nurul 'Ain Sham Ismail ◽  
See Yen Yong ◽  
Wei Ting Teo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Serum Creatinine ◽  
Post Treatment ◽  
Angiogenic Factor ◽  
Renal Outcome ◽  
Vascular Endothelial ◽  
Anti Vegf ◽  
Endothelial Growth Factor

Abstract Background and Aims Intravenous (IV) anti-vascular endothelial growth factor(VEGF) is a potent anti-angiogenic factor for the treatment of solid tumours. While, intravitreal anti-VEGF injection is used in the treatment for macular and retinal diseases. The effects of IV anti-VEGF agents are well documented to cause hypertension, renal impairment and proteinuria. However only few reports showed the significance of intravitreal anti-VEGF injection causing minimal change disease (MCD) and acute kidney injury (AKI). Hence, this study is to determine the outcome of renal function following intravitreal anti-VEGF injection. Method This is a prospective, cross sectional study recruiting patients from ophthalmology day-care operation theatre that were scheduled for intravitreal anti-VEGF injection in University Malaya Medical Centre (UMMC). On the day of the injection of anti-VEGF, patients’ demographic data (age, gender, medical background, medications), blood pressure, height, weight and investigations for serum creatinine and urine protein creatinine ratio (PCR) were collected. Following these, they will receive the intravitreal anti-VEGF as per schedule. All these patients were given a follow-up within 72hours to reassess blood pressure, serum creatinine and urine PCR. Results A total of 90 patients were recruited. However, 15 patients were subsequently excluded as there was no repeated serum creatinine at 72-hours post treatment. Their mean age was 67.25 ± 10.41. Among all, 3 patients had significance increased in serum creatinine (4%) with significance changed of urine PCR post treatment. Table 1 showed baseline parameters prior to treatment and table 2 was post treatment parameters. Higher serum creatinine and proteinuria pre intravitreal anti-VEGF were identified to have higher OR of 1.018 (95% CI 1.001-1.035) (p=0.043) and OR 1.004 (1.000-1.007) (p=0.025) respectively among those who developed AKI. In assessing the association between higher pre-treatment creatinine and proteinuria (independent variable) and development of AKI (dependent variable) estimated by logistic regression with no AKI as a reference group we found that there were no significance. Conclusion Following intravitreal anti-VEGF administration, there were no significant changes in blood pressure. However, 4% from our cohort had AKI and worsening proteinuria at 72 hours post treatment. These patients had higher serum creatinine and proteinuria prior to treatment. However, our study is underpowered to establish the relationship between intravitreal anti-VEGF and development of AKI. Further study with larger sample size and longer-term outcome is needed.

scholarly journals The Influence of Noise Intensity and Age to the Employees’ Blood Pressure at Heavy-Duty Shop and EHS Department

2019 ◽  
Vol 8 (2) ◽  
pp. 168
Author(s):  
Achmad Fachrul Megananda ◽  
Tjipto Suwandi
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Noise Intensity ◽  
Health Problems ◽  
Pressure Increase ◽  
P Value ◽  
Heavy Duty ◽  
Blood Pressure Increase ◽  
Influence Of Noise

Introduction: Noise is an unwanted sound heard by the hearers, which can trigger health problems if it continues to be exposed to a certain intensity. One of the health problems that can arise due to noise is the blood pressure increase. This study aims to analyze the influence of noise intensity and age to the blood pressure increase. Methods: This study was an observational study completed with cross-sectional design and analytics. The independent variables in this study were the noise intensity and age, while the dependent variable was the blood pressure. The sample collection of this study applied the total sampling method with 46 employees as respondents, i.e., 29 employees of the heavy-duty shop and 17 employees of the EHS Department in PT. Vale Indonesia. The data analysis was conducted by using the logistic regression statistical test with α-value of 0.05. Results: the noise intensity affected the increase of both systolic blood pressure (significance/p-value=0.00) and diastolic blood pressure (significance/p-value=0.01) with an odds ratio of the increase of systolic blood pressure (Exp (B) =9.75) and the increase of diastolic blood pressure (Exp (B)=5.76). Furthermore, the variable of age does not influence the increase of both systolic (significance/p-value=0.57) and diastolic (significance/p-value=0.41) blood pressures. Conclusion:  the rise of the blood pressure of the employees is affected by the noise intensity factor in the workplace. Keywords: noise intensity, age, blood pressure

scholarly journals Class A1 scavenger receptor prevents obesity-associated blood pressure elevation through suppressing overproduction of vascular endothelial growth factor B in macrophages

2020 ◽  
Author(s):  
Xudong Zhu ◽  
Yan Wang ◽  
Liu Zhu ◽  
Ye Zhu ◽  
Kun Zhang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Scavenger Receptor ◽  
Vascular Endothelial ◽  
Obese Mice ◽  
Blood Pressure Elevation ◽  
Perivascular Adipose Tissue ◽  
Factor B ◽  
Endothelial Growth Factor

Abstract Aims Dysfunctional innate immune function and inflammation contributes to the pathogenesis of obesity-associated hypertension, in which macrophage infiltration in the perivascular adipose tissue (PVAT) plays a key role. However, the mechanisms behind it are not well understood. Class A1 scavenger receptor (SR-A1) is one of the major pattern recognition receptors in modulating macrophage activity, and here, we aimed to investigate its role in obesity-associated hypertension. Methods and results Both diet-induced and genetic obesity were generated in mice. Deficiency in SR-A1 aggravated the obesity-induced blood pressure (BP) elevation and endothelial dysfunction in mice. The BP-elevating effect of SR-A1 deficiency was blocked by the down-regulation of vascular endothelial growth factor B (VEGF-B) in obese mice. Overexpression of VEGF-B raised BP in the obese mice but not in normal mice. Administration of fucoidan, a ligand of SR-A1, lowered BP, and VEGF-B levels in Sr-a1+/+ but not in Sr-a1−/− obese mice. Conclusion These results reveal a new link between PVAT and vascular biology in obesity orchestrated by the SR-A1/VEGF-B axis in macrophages. SR-A1 and VEGF-B may be promising therapeutic targets in the treatment of obesity-associated hypertension.

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