Successful Management of Recurrent Subacute Thyroiditis by Adding Colchicine to Glucocorticoid Treatment: A Case Series Study

2020 ◽  
Vol 52 (10) ◽  
pp. 712-717
Author(s):  
Zhenhua Tian ◽  
Yu Su ◽  
Meijie Zhang ◽  
Xiujuan Zhang ◽  
Qingbo Guan
Keyword(s):  
Large Scale ◽  
Case Series ◽  
Blood Parameters ◽  
Subacute Thyroiditis ◽  
Recurrent Pain ◽  
Double Blind ◽  
Glucocorticoid Treatment ◽  
Case Series Study ◽  
Series Study

AbstractAlthough subacute thyroiditis (SAT) is thought to be a self-limited inflammatory thyroid disease, the recurrence rate of SAT is approximately 10–20%. It is difficult for these patients to stop glucocorticoid treatment, and they are usually bothered with recurrent pain and the side effects of glucocorticoids for more than several months. We describe three cases who were diagnosed with recurrent subacute thyroiditis after a reduction in prednisolone (PSL) dose, either immediately upon the cessation of PSL or shortly thereafter. Their symptoms, including the adverse effects of PSL, severely impacted their quality of life. After a complete assessment, we administered colchicine at 1 mg per day for 1–2 months to control the recurrence of SAT and monitored their routine blood parameters every two weeks. All 3 patients were successfully tapered off of PSL treatment and were free of frequently recurrent SAT. Colchicine may be therapeutic in patients with prednisolone-refractory, recurrent SAT. However, a large-scale, double-blind, controlled, prospective multicenter study is required to provide a solid body of evidence.

scholarly journals Gender associated differences in determinants of quality of life in patients with COPD: a case series study

2006 ◽  
Vol 4 (1) ◽  
Author(s):  
Juan P de Torres ◽  
Ciro Casanova ◽  
Concepción Hernández ◽  
Juan Abreu ◽  
Angela Montejo de Garcini ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Case Series ◽  
Case Series Study ◽  
Series Study

scholarly journals A CRITICAL GUIDE TO CASE SERIES REPORTS

2005 ◽  
pp. 128-133
Author(s):  
Timothy S. Carey ◽  
Scott D. Boden
Keyword(s):  
Case Series ◽  
Case Definition ◽  
Research Literature ◽  
Substantial Contribution ◽  
Funding Sources ◽  
Case Series Study ◽  
Study Population ◽  
Study Designs ◽  
Series Study

Objective. Provide guidance to investigators and authors regarding appropriate conduct and reporting of case-series studies. Summary of Background Data. Evidence-based practice has provided a substantial contribution to advancing clinical science. Many study designs have been critically examined, and the quality of the research literature has improved. A common study design in musculoskeletal medicine is the case series: a description of the course of patients over time. Case series can provide valuable information as to: case definition, trend analyses regarding outcomes, and clues as to causation. Case series cannot be used to draw inferences regarding treatment effect. Methods. Examination of previous work on identification of characteristics of high quality study designs such as cohort studies; extending this work to case series. Results. We identified draft characteristics that good case series studies should address: clearly defined study question; well- described study population; well-described intervention; use of validated outcome measures; appropriate statistical analyses; well-described results; discussion/conclusions supported by the data presented; funding sources acknowledged. Conclusions. We propose these measures to authors and journal editors as one mechanism to improve the quality of the case series study.

scholarly journals The impact of bilateral endoscopic inferior turbinoplasty with or without adenoidectomy on the quality of life of children: a retrospective case series study

2019 ◽  
Vol 48 (1) ◽  
Author(s):  
Ahmed Mourad ◽  
Hussein Jaffal ◽  
Ismaeel El-Hakim ◽  
Hamdy El-Hakim
Keyword(s):  
Quality Of Life ◽  
Case Series ◽  
Retrospective Case ◽  
Retrospective Case Series ◽  
Case Series Study ◽  
The Impact ◽  
Series Study

Abstract Background Inferior turbinoplasty (IT) and adenoidectomy (Ad) are frequently resorted to in children with chronic rhinitis (CR) refractory to medical therapy. The aim of this study is to document the long-term improvement in quality of life (QOL) in children with CR following endoscopic IT with or without Ad. Methods A retrospective case series study was conducted. We searched a prospectively kept surgical database for children ≤18 years old who had CR who underwent endoscopic IT with or without Ad between 2009 and 2016 at a tertiary care children’s center. Patients with sinonasal pathologies other than CR, had craniofacial syndromes or dysmorphism and had other sinonasal procedures or trauma were excluded. Collected data included demographics, secondary diagnoses, duration of follow-up, and complications of procedures. The Glasgow Children’s Benefit Inventory (GCBI) was administered by phone to assess QOL improvement. Results One hundred sixty-five eligible subjects were identified. Eighty-nine subjects met the inclusion criteria. Data was collected for the 60 subjects that were reached. Forty-two patients had IT only while 18 had IT and Ad. The mean age was 10.7 ± 2.7 years, with 31 males and 29 females. The median duration of follow-up (25th, 75th percentile) was 38.1 months (24.6, 55.8). The median GCBI score (25th, 75th percentile) was 22.9 (6.3, 39.6) revealing an overall positive benefit in all domains. There was only one complication. Conclusions This study validates prior findings regarding improvement of QOL and safety of IT with or without Ad for children with CR and indicates it is maintained in the long term.

scholarly journals All-Cause Hospitalizations after Large-Scale Hurricanes among Older Adults: A Self-Controlled Case Series Study

2020 ◽  
pp. 1-7
Author(s):  
Sue Anne Bell ◽  
Theodore J. Iwashyna ◽  
Xingyu Zhang ◽  
Bingxin Chen ◽  
Matthew A. Davis
Keyword(s):  
Large Scale ◽  
Health Planning ◽  
Case Series ◽  
Admission Rate ◽  
Hurricane Sandy ◽  
Care Utilization ◽  
Older Americans ◽  
Study Objective ◽  
Case Series Study ◽  
Series Study

Abstract Introduction: Understanding the drivers of health care utilization patterns following disasters can better support health planning. This study characterized all-cause hospitalizations among older Americans after eight large-scale hurricanes. Study Objective: The objective of this study was to characterize all-cause hospitalizations for any cause among older Americans in the 30 days after eight large-scale hurricanes. Methods: A self-controlled case series study among Medicare beneficiaries (age 65+) exposed to one of eight hurricanes was conducted. The predicted probability of sociodemographic factors associated with hospitalization using logit models was estimated. Results: Hurricane Sandy (2012) had the highest post-hurricane admission rate, a 23% increase (incidence rate ratio [IRR] = 1.23; 95% CI, 1.22-1.24), while Hurricane Irene in 2011 had only a 10% increase (IRR = 1.10; 95% CI, 1.09-1.11). Higher likelihood of hospitalization occurring after hurricanes included being 85 or older (36.8% probability of hospitalization; 95% CI, 34.7-39.0) and being dually eligible for Medicare and Medicaid (62.8%; 95% CI, 60.7-64.9). Conclusion: Planning to address the surge in hospitalization for a longer time period after hurricanes and interventions targeted to support aging Americans are needed.

scholarly journals Percutaneous Image-Guided Vertebral Fixation in Cancer-Related Vertebral Compression Fractures: A Case Series Study

Medicina ◽  
2021 ◽  
Vol 57 (9) ◽  
pp. 907
Author(s):  
Francois H. Cornelis ◽  
Leo Razakamanantsoa ◽  
Mohamed Ben Ammar ◽  
Milan Najdawi ◽  
Francois Gardavaud ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Case Series ◽  
Lumbar Vertebrae ◽  
Vertebral Compression Fractures ◽  
Compression Fractures ◽  
Pain Scores ◽  
Case Series Study ◽  
Adjacent Fractures ◽  
Series Study

Background and objectives: Cancer-related vertebral compression fractures (VCF) may cause debilitating back pain and instability, affecting the quality of life of cancer patients. To further drive cement deposition during vertebroplasty, the aims of this restrospective case series study were to report the feasibility, safety and short term efficacy (≤6 months) of percutaneous vertebral fixation in cancer-related vertebral compression fractures using various intravertebral implants. Methods: All consecutive cancer patients treated with percutaneous vertebral fixation for VCF were retrospectively included. Various devices were inserted percutaneously under image guidance and filled by cement. Descriptive statistics were used and a matched paired analysis of pain scores was performed to assess for changes following interventions. Results: A total of 18 consecutive patients (12 women (66.6%) and 6 men (33.3%); mean age 59.7 ± 15.5 years) were included. A total of 42 devices were inserted in 8 thoracic and 16 lumbar vertebrae. Visual analogue scale measurement significantly improved from 5.6 ± 1.8 preoperatively to 1.5 ± 1.7 at 1 week (p < 0.01) and to 1.5 ± 1.3 at 6 months (p < 0.01). No severe adverse events were observed, but three adjacent fractures occurred between 1 week and 5 months after implantation. Conclusions: Percutaneous vertebral fixation of cancer-related VCF is feasible and safe and allows pain relief.

An Investigation of Aspects of Design of Resin-Bonded Bridges in General Dental Practice and Hospital Services

2004 ◽  
Vol os11 (3) ◽  
pp. 87-89 ◽  
Author(s):  
Eleni Patsiatzi ◽  
Nick JA Grey
Keyword(s):  
Best Practice ◽  
Case Series ◽  
Retrospective Case ◽  
Fixed Design ◽  
Metal Framework ◽  
Case Series Study ◽  
Single Tooth ◽  
Dental Practitioners ◽  
Series Study

Purpose of study To assess the design of resin-bonded bridges (RBBs) by dentists, the quality of information provided to a dental laboratory, and aid identification of best practice. Design A retrospective case series study of slips for RBB construction, sent by hospital and general dental practitioners to a dental laboratory based in a postgraduate dental institute in Scotland, UK. Main findings 384 forms were reviewed. For single-tooth replacements, 40% of designs for upper anterior bridges and 46% for lower posterior bridges were fixed-fixed (F-F) when a cantilever design was a better option. Thirty-six (9.3%) of RBB designs involved double abutting. On the laboratory forms, fewer than five (1%) cases included instructions about the thickness of the metal framework and in 48% there was no reference to the extension of the metal framework. Principal conclusions For single-tooth replacements, a relatively high percentage of dentists prescribed a fixed-fixed design for RBBs, despite the evidence advocating the use of a cantilever design. A significant number of dentists used double abutments. The information provided to the laboratory for the construction of resin-bonded bridges was often insufficient.

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