Cross-Dehydrogenative coupling reaction and arylation of quinoxalin-2(1H)-ones under iodide/peroxide system condition
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A simple method has been developed for the synthesis of 3-(2-oxo-2-phenylethylidene)-3,4-dihydroquinoxalin-2(1H)-one and 3-aryl-quinoxalin-2(1H)-one derivatives through C-H activation of quinoxalin-2(1H)-ones by peroxides and iodide. In this protocol, the peroxide (TBPB) serves as both the radical initiator and aryl source, realizing arylation of quinoxalin-2(1H)-one in a one-step reaction. The methodology has the advantages of being a metal-free strategy and having broad functional group tolerance.
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2016 ◽
Vol 57
(6)
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pp. 680-683
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Keyword(s):
2016 ◽
Vol 57
(33)
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pp. 3701-3705
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2018 ◽
Vol 73
(5)
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pp. 295-303
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2018 ◽
Vol 83
(21)
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pp. 13030-13035
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