Synthesis of a new phorbazole and its derivatives

Phorbazoles are chlorinated marine alkaloids isolated from sea sponges and nudibranchs. In this work, a convenience synthetic method leading to a new phorbazole and its derivatives was developed. This synthesis of the novel phorbazole G and its derivatives has been Phorbazoles are chlorinated marine alkaloids containing pyrrole, oxazole, phenol ring units and differ in the number and positions of chlorine atoms. They are isolated from sea sponges and nudibranchs. In this work, a convenient synthetic method leading to a new phorbazole and its derivatives was developed. This synthesis of the synthetic phorbazole G and its derivatives has been achieved in seven steps in good overall yields of 26-52 %. It involved formation of the pyrrole oxazole skeleton followed by chlorination. The pyrrole oxazole skeleton was synthesized from pyrrole and substituted acetophenones, and the key step was cyclodehydration of the amides to give protected oxazoles, followed by hydrolysis. achieved in seven steps in good overall yields of 26.3 - 52.5 %. It involved formation of the pyrrole oxazole skeleton followed by chlorination. The pyrrole oxazole skeleton was synthesized from pyrrole and substituted acetophenones, and the key step was cyclodehydration of the amides to give protected oxazoles, followed by hydrolysis