Tobacco Associated Bronchiolitis (Small Airway Disease, Chronic Obstructive Bronchiolitis)

2005 ◽  
Keyword(s):  
Airway Disease ◽  
Small Airway ◽  
Chronic Obstructive ◽  
Small Airway Disease

scholarly journals Determining Response to Treatment for Drug-Induced Bronchocentric Granulomatosis by the Forced Oscillation Technique

Medicina ◽  
2021 ◽  
Vol 57 (12) ◽  
pp. 1315
Author(s):  
Susumu Fukahori ◽  
Yasushi Obase ◽  
Chizu Fukushima ◽  
Daisuke Takao ◽  
Jun Iriki ◽  
...  
Keyword(s):  
Forced Oscillation ◽  
Airway Disease ◽  
Small Airway ◽  
Response To Treatment ◽  
Chronic Obstructive ◽  
Forced Oscillation Technique ◽  
Small Airways ◽  
Small Airway Disease ◽  
Bronchocentric Granulomatosis ◽  
Effect Of Treatment

Anti-tumor necrosis factor alpha (TNFα) therapy is widely used to treat various inflammatory conditions. Paradoxically, there are several case reports describing the development of bronchocentric granulomatosis treated with TNFα inhibitors, and it is difficult to determine the effect of treatment using conventional spirometry because the lesions are located in small airways. However, it has been reported that the forced oscillation technique (FOT) is useful in the evaluation of small airway disease in bronchial asthma or chronic obstructive pulmonary disease. We performed the FOT to determine the effect of treatment on bronchocentric granulomatosis and found it to be useful. We report the case of a 55-year-old female with ulcerative colitis who was treated with golimumab and who developed bronchocentric granulomatosis as a sarcoid-like reaction to golimumab. She was successfully treated with prednisone, and the treatment efficacy was confirmed by the FOT. The FOT may be useful in the evaluation of small airway disease in bronchocentric granulomatosis. This case may help inform clinicians of the usefulness of the FOT to assess small airway disease in various diseases.

scholarly journals PECULIARITIES OF BRONCHIAL ASTHMA CLINICAL COURSE IN SMOKERS WITH SMALL AIRWAY DISEASES

2020 ◽  
pp. 8-21
Author(s):  
V.V. Gnoevykh ◽  
Yu.A. Shorokhova ◽  
A.Yu. Smirnova ◽  
A.B. Peskov ◽  
V.A. Razin
Keyword(s):  
Bronchial Asthma ◽  
Clinical Course ◽  
Airway Disease ◽  
Small Airway ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Small Airway Disease ◽  
Airway Diseases ◽  
Related Phenotype ◽  
Keywords Bronchial Asthma

The literature review provides up-to-date information about the clinical course of bronchial asthma (BA) in smokers with small airway diseases. Special attention is paid to the combination of bronchial asthma and chronic obstructive pulmonary disease (COPD), namely asthma-COPD overlap syndrome (ACOS). According to literature data, in case of small airway duseases exacerbations are more often and severe in smokers with BA and ACOS. Besides, disease prognosis worsens due to reduction in the efficacy of a baseline therapy. Keywords: bronchial asthma, small airway disease, smoking-related phenotype, asthma-COPD overlap (BA-COPD phenotype). В литературном обзоре представлены современные сведения об особенностях клинического течения бронхиальной астмы (БА) у курильщиков с поражением малых дыхательных путей (МДП). Особое внимание уделено сочетанию бронхиальной астмы и хронической обструктивной болезни лёгких (ХОБЛ; COPD) – синдрому перекрёста БА-ХОБЛ (СПБАХ, asthma-COPD overlap, ACO; фенотип БА-ХОБЛ). Согласно литературным данным, в случае поражения МДП у больных БА с фенотипом курильщика и при сочетании БА-ХОБЛ чаще возникают и тяжелее протекают обострения, ухудшается прогноз заболевания, в т.ч. из-за снижения эффективности базисной терапии. Ключевые слова: бронхиальная астма, поражение малых дыхательных путей, фенотип курильщика, asthma-COPD overlap (фенотип БА-ХОБЛ).

scholarly journals Computed tomography airway tree tortuosity features predict functional small airway disease in chronic obstructive pulmonary disease

2021 ◽  
Author(s):  
Daniel Genkin ◽  
Danesh Aslam ◽  
Jason Bartlett
Keyword(s):  
Computed Tomography ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Airway Disease ◽  
Small Airway ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Small Airway Disease ◽  
Full Inspiration ◽  
Airway Tree

Over 1 000 000 Canadians are diagnosed with Chronic Obstructive Pulmonary Disease (COPD) and by 2020 the disease will be the third deadliest on Earth. Despite high prevalence, diagnosis of COPD occurs late in the disease course, after a large portion of the small airways are destroyed. Current methods to quantify small airway disease (SAD) using the Disease Probability Measure (DPM) approach requires CT images acquired at full inspiration and full expiration, and therefore there are technical challenges and dose concerns Computed Tomography (CT) imaging using only a single full inspiration CT image can be used segment the central airway tree and generate quantitative morphometric measurements.

scholarly journals Computed tomography airway tree tortuosity features predict functional small airway disease in chronic obstructive pulmonary disease

2021 ◽  
Author(s):  
Daniel Genkin ◽  
Danesh Aslam ◽  
Jason Bartlett
Keyword(s):  
Computed Tomography ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Airway Disease ◽  
Small Airway ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Small Airway Disease ◽  
Full Inspiration ◽  
Airway Tree

Over 1 000 000 Canadians are diagnosed with Chronic Obstructive Pulmonary Disease (COPD) and by 2020 the disease will be the third deadliest on Earth. Despite high prevalence, diagnosis of COPD occurs late in the disease course, after a large portion of the small airways are destroyed. Current methods to quantify small airway disease (SAD) using the Disease Probability Measure (DPM) approach requires CT images acquired at full inspiration and full expiration, and therefore there are technical challenges and dose concerns Computed Tomography (CT) imaging using only a single full inspiration CT image can be used segment the central airway tree and generate quantitative morphometric measurements.

Sign in / Sign up

Export Citation Format

Share Document