scholarly journals Determining Response to Treatment for Drug-Induced Bronchocentric Granulomatosis by the Forced Oscillation Technique

Medicina ◽  
2021 ◽  
Vol 57 (12) ◽  
pp. 1315
Author(s):  
Susumu Fukahori ◽  
Yasushi Obase ◽  
Chizu Fukushima ◽  
Daisuke Takao ◽  
Jun Iriki ◽  
...  
Keyword(s):  
Forced Oscillation ◽  
Airway Disease ◽  
Small Airway ◽  
Response To Treatment ◽  
Chronic Obstructive ◽  
Forced Oscillation Technique ◽  
Small Airways ◽  
Small Airway Disease ◽  
Bronchocentric Granulomatosis ◽  
Effect Of Treatment

Anti-tumor necrosis factor alpha (TNFα) therapy is widely used to treat various inflammatory conditions. Paradoxically, there are several case reports describing the development of bronchocentric granulomatosis treated with TNFα inhibitors, and it is difficult to determine the effect of treatment using conventional spirometry because the lesions are located in small airways. However, it has been reported that the forced oscillation technique (FOT) is useful in the evaluation of small airway disease in bronchial asthma or chronic obstructive pulmonary disease. We performed the FOT to determine the effect of treatment on bronchocentric granulomatosis and found it to be useful. We report the case of a 55-year-old female with ulcerative colitis who was treated with golimumab and who developed bronchocentric granulomatosis as a sarcoid-like reaction to golimumab. She was successfully treated with prednisone, and the treatment efficacy was confirmed by the FOT. The FOT may be useful in the evaluation of small airway disease in bronchocentric granulomatosis. This case may help inform clinicians of the usefulness of the FOT to assess small airway disease in various diseases.

Clinical Significance of Forced Oscillation Technique for Evaluation of Small Airway Disease in Interstitial Lung Diseases

Lung ◽  
2016 ◽  
Vol 194 (6) ◽  
pp. 975-983 ◽  
Author(s):  
Masashi Mikamo ◽  
Tomoyuki Fujisawa ◽  
Yoshiyuki Oyama ◽  
Masato Kono ◽  
Noriyuki Enomoto ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Lung Diseases ◽  
Forced Oscillation ◽  
Airway Disease ◽  
Interstitial Lung Diseases ◽  
Small Airway ◽  
Forced Oscillation Technique ◽  
Small Airway Disease

scholarly journals Lung clearance index: assessment and utility in children with asthma

2019 ◽  
Vol 28 (154) ◽  
pp. 190046 ◽  
Author(s):  
Amy G. L. Nuttall ◽  
Werner Velásquez ◽  
Caroline S. Beardsmore ◽  
Erol A. Gaillard
Keyword(s):  
Early Stage ◽  
Airway Disease ◽  
Small Airway ◽  
Small Airways ◽  
Lung Clearance ◽  
Additional Information ◽  
Small Airway Disease ◽  
Lung Clearance Index ◽  
Children With Asthma ◽  
Ventilation Heterogeneity

There is increasing evidence that ventilation heterogeneity and small airway disease are significant factors in asthma, with evidence suggesting that the small airways are involved from an early stage in childhood asthma. Spirometry is commonly used to monitor lung function in asthmatics; however, it is not sensitive to small airway disease. There has been renewed interest in multibreath washout (MBW) tests, with recognition of the lung clearance index (LCI) as a global index of abnormality in gas mixing of the lungs that therefore also reflects small airway disease. This review summarises the technical and practical aspects of the MBW/LCI in children, and the differences between commercially available equipment. Children with severe asthma are more likely to have an abnormal LCI, whereas most children with mild-to-moderate asthma have an LCI within the normal range, but slightly higher than age-matched healthy controls. Monitoring children with asthma with MBW alongside standard spirometry may provide useful additional information.

scholarly journals Gene expression profiling of bronchial brushes is associated with the level of emphysema measured by computed tomography-based parametric response mapping

2020 ◽  
Vol 318 (6) ◽  
pp. L1222-L1228
Author(s):  
Senani N. H. Rathnayake ◽  
Firdaus A. A. Mohamed Hoesein ◽  
Craig J. Galban ◽  
Nick H. T. ten Hacken ◽  
Brian G. G. Oliver ◽  
...  
Keyword(s):  
Gene Expression ◽  
Computed Tomography ◽  
Airway Disease ◽  
Small Airway ◽  
Study Cohort ◽  
Small Airways ◽  
Air Trapping ◽  
Response Mapping ◽  
Small Airway Disease ◽  
Parametric Response

Parametric response mapping (PRM) is a computed tomography (CT)-based method to phenotype patients with chronic obstructive pulmonary disease (COPD). It is capable of differentiating emphysema-related air trapping with nonemphysematous air trapping (small airway disease), which helps to identify the extent and localization of the disease. Most studies evaluating the gene expression in smokers and COPD patients related this to spirometric measurements, but none have investigated the relationship with CT-based measurements of lung structure. The current study aimed to examine gene expression profiles of brushed bronchial epithelial cells in association with the PRM-defined CT-based measurements of emphysema (PRMEmph) and small airway disease (PRMfSAD). Using the Top Institute Pharma (TIP) study cohort (COPD = 12 and asymptomatic smokers = 32), we identified a gene expression signature of bronchial brushings, which was associated with PRMEmph in the lungs. One hundred thirty-three genes were identified to be associated with PRMEmph. Among the most significantly associated genes, CXCL11 is a potent chemokine involved with CD8+ T cell activation during inflammation in COPD, indicating that it may play an essential role in the development of emphysema. The PRMEmph signature was then replicated in two independent data sets. Pathway analysis showed that the PRMEmph signature is associated with proinflammatory and notch signaling pathways. Together these findings indicate that airway epithelium may play a role in the development of emphysema and/or may act as a biomarker for the presence of emphysema. In contrast, its role in relation to functional small airways disease is less clear.

scholarly journals PECULIARITIES OF BRONCHIAL ASTHMA CLINICAL COURSE IN SMOKERS WITH SMALL AIRWAY DISEASES

2020 ◽  
pp. 8-21
Author(s):  
V.V. Gnoevykh ◽  
Yu.A. Shorokhova ◽  
A.Yu. Smirnova ◽  
A.B. Peskov ◽  
V.A. Razin
Keyword(s):  
Bronchial Asthma ◽  
Clinical Course ◽  
Airway Disease ◽  
Small Airway ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Small Airway Disease ◽  
Airway Diseases ◽  
Related Phenotype ◽  
Keywords Bronchial Asthma

The literature review provides up-to-date information about the clinical course of bronchial asthma (BA) in smokers with small airway diseases. Special attention is paid to the combination of bronchial asthma and chronic obstructive pulmonary disease (COPD), namely asthma-COPD overlap syndrome (ACOS). According to literature data, in case of small airway duseases exacerbations are more often and severe in smokers with BA and ACOS. Besides, disease prognosis worsens due to reduction in the efficacy of a baseline therapy. Keywords: bronchial asthma, small airway disease, smoking-related phenotype, asthma-COPD overlap (BA-COPD phenotype). В литературном обзоре представлены современные сведения об особенностях клинического течения бронхиальной астмы (БА) у курильщиков с поражением малых дыхательных путей (МДП). Особое внимание уделено сочетанию бронхиальной астмы и хронической обструктивной болезни лёгких (ХОБЛ; COPD) – синдрому перекрёста БА-ХОБЛ (СПБАХ, asthma-COPD overlap, ACO; фенотип БА-ХОБЛ). Согласно литературным данным, в случае поражения МДП у больных БА с фенотипом курильщика и при сочетании БА-ХОБЛ чаще возникают и тяжелее протекают обострения, ухудшается прогноз заболевания, в т.ч. из-за снижения эффективности базисной терапии. Ключевые слова: бронхиальная астма, поражение малых дыхательных путей, фенотип курильщика, asthma-COPD overlap (фенотип БА-ХОБЛ).

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