Simple and Efficient Synthesis of Racemic Substituted Mandelic Acid Esters from Nonactivated Arenes and Ethyl Glyoxylate

Synthesis ◽  
2008 ◽  
Vol 2008 (20) ◽  
pp. 3237-3244
Author(s):  
Janusz Jurczak ◽  
Jacek Kwiatkowski ◽  
Jakub Majer ◽  
Piotr Kwiatkowski
Keyword(s):  
Mandelic Acid ◽  
Efficient Synthesis ◽  
Acid Esters

ChemInform Abstract: Simple and Efficient Synthesis of Racemic Substituted Mandelic Acid Esters from Nonactivated Arenes and Ethyl Glyoxylate.

ChemInform ◽  
2009 ◽  
Vol 40 (8) ◽  
Author(s):  
Jacek Kwiatkowski ◽  
Jakub Majer ◽  
Piotr Kwiatkowski ◽  
Janusz Jurczak
Keyword(s):  
Mandelic Acid ◽  
Efficient Synthesis ◽  
Acid Esters

Efficient Synthesis of (R)- and (S)-α-(Hydroxymethyl)pyroglutamic Acid Esters from l-Proline

Synthesis ◽  
2009 ◽  
Vol 2009 (22) ◽  
pp. 3751-3756 ◽  
Author(s):  
Tetsuro Shinada ◽  
Yasufumi Ohfune ◽  
Hiroki Yoshida
Keyword(s):  
Pyroglutamic Acid ◽  
Efficient Synthesis ◽  
Acid Esters

Enantioselective Equilibration−Access to Chiral Aldol Adducts of Mandelic Acid Esters

2006 ◽  
Vol 8 (23) ◽  
pp. 5353-5355 ◽  
Author(s):  
Stefan Scholtis ◽  
Andreas Ide ◽  
Rainer Mahrwald
Keyword(s):  
Mandelic Acid ◽  
Acid Esters

RhCl3·3H2O-Catalyzed Regioselective C(sp2)–H Alkoxycarbonylation: Efficient Synthesis of Indole- and Pyrrole-2-carboxylic Acid Esters

ACS Catalysis ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 5545-5551 ◽  
Author(s):  
Kang Zhao ◽  
Rongrong Du ◽  
Bingyang Wang ◽  
Jianhua Liu ◽  
Chungu Xia ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Efficient Synthesis ◽  
Acid Esters

Copper-catalyzed intramolecular redox reaction: Asymmetric synthesis of chiral 2-(1H-pyrrol-1-yl)-mandelic acid esters

Tetrahedron ◽  
2018 ◽  
Vol 74 (52) ◽  
pp. 7480-7484
Author(s):  
Hong-Jin Du ◽  
Chao Lin ◽  
Xiaoan Wen ◽  
Qing-Long Xu
Keyword(s):  
Asymmetric Synthesis ◽  
Redox Reaction ◽  
Mandelic Acid ◽  
Acid Esters

Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to Glyoxylates: Access to Optically Active Substituted Mandelic Acid Esters

Synlett ◽  
2019 ◽  
Vol 30 (14) ◽  
pp. 1693-1697
Author(s):  
Diao Chen ◽  
Jian-Guo Liu ◽  
Xu Zhang ◽  
Ming-Hua Xu
Keyword(s):  
Catalytic System ◽  
Mandelic Acid ◽  
Optically Active ◽  
Antiplatelet Drug ◽  
Reaction Conditions ◽  
Formal Synthesis ◽  
Arylboronic Acids ◽  
Synthetic Utility ◽  
Enantioselective Addition ◽  
Acid Esters

A rhodium-catalyzed enantioselective addition of glyoxylates to arylboronic acids promoted by a simple chiral sulfinamide-based olefin ligand under mild reaction conditions is described. The reaction provides access to a variety of optically active substituted mandelic acid esters in good yields with up to 83% ee. The catalytic system is also applicable to pyruvate addition. The synthetic utility of this method is highlighted by a formal synthesis of the antiplatelet drug clopidogrel.

ChemInform Abstract: Rapid and Efficient Synthesis of (R)-Aryloxypropionic Acid Esters under Microwave Irradiation.

ChemInform ◽  
2011 ◽  
Vol 42 (10) ◽  
pp. no-no
Author(s):  
Zbigniew Ochal ◽  
Krzysztof Durka ◽  
Lukasz Banach
Keyword(s):  
Microwave Irradiation ◽  
Efficient Synthesis ◽  
Acid Esters
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