Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

2015 ◽  
Vol 53 (01) ◽  
Author(s):  
Z Abdullah ◽  
P Hackstein ◽  
J Trebicka ◽  
M Beyer ◽  
JL Schultze ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Immune Responses ◽  
Bacterial Infection ◽  
Microbial Translocation ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Systemic Bacterial Infection

scholarly journals The role of type 1 interferons in Gram-negative bacteria-induced coagulation

Blood ◽  
2020 ◽  
Author(s):  
Xinyu Yang ◽  
Xiaoye Cheng ◽  
Yiting Tang ◽  
Xianhui Qiu ◽  
Zhongtai Wang ◽  
...  
Keyword(s):  
Immune Responses ◽  
Bacterial Infection ◽  
Innate Immune ◽  
Coagulation Cascade ◽  
Outer Cell ◽  
Gram Negative Bacteria ◽  
Innate Immune Responses ◽  
Gram Negative ◽  
Type 1 Interferons

Bacterial infection not only stimulates innate immune responses but also activates the coagulation cascades. Over-activation of the coagulation system in bacterial sepsis leads to disseminated intravascular coagulation (DIC), a life-threatening condition. However, the mechanisms by which bacterial infection activates the coagulation cascade are not fully understood. Here we show that type 1 interferons (IFNs), widely expressed family of cytokines that orchestrate innate antiviral and antibacterial immunity, mediate bacterial infection-induced DIC through amplifying the release of high mobility box group box 1 (HMGB1) into the blood stream. Inhibition of the expression of type 1 IFNs, disruption of their receptor IFN-α/βR or downstream effector (e.g., HMGB1) uniformly decreased Gram-negative bacteria-induced DIC. Mechanistically, extracellular HMGB1 markedly increased the pro-coagulant activity of tissue factor (TF) by promoting the externalization of phosphatidylserine (PS) to the outer cell surface, where PS assembles a complex of cofactor-proteases of the coagulation cascades. These findings not only provide novel insights into the link between innate immune responses and coagulation, but also open a new avenue for developing novel therapeutic strategies to prevent DIC in sepsis.

Effects of Antihistamines on Innate Immune Responses to Severe Bacterial Infection in Mice

2011 ◽  
Vol 155 (4) ◽  
pp. 355-360 ◽  
Author(s):  
Martin Metz ◽  
Elizabeth Doyle ◽  
Carsten Bindslev-Jensen ◽  
Takeshi Watanabe ◽  
Torsten Zuberbier ◽  
...  
Keyword(s):  
Immune Responses ◽  
Bacterial Infection ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Severe Bacterial Infection

scholarly journals Elevated CO2 suppresses specific Drosophila innate immune responses and resistance to bacterial infection

2009 ◽  
Vol 106 (44) ◽  
pp. 18710-18715 ◽  
Author(s):  
I. T. Helenius ◽  
T. Krupinski ◽  
D. W. Turnbull ◽  
Y. Gruenbaum ◽  
N. Silverman ◽  
...  
Keyword(s):  
Immune Responses ◽  
Bacterial Infection ◽  
Elevated Co2 ◽  
Innate Immune ◽  
Innate Immune Responses

Elastase- And LPS-Exposed Mice Exhibit Impaired Innate Immune Responses To Bacterial Infection

2010 ◽  
Author(s):  
Shyamala Ganesan ◽  
Adam Comstock ◽  
Sangbrita Chattoraj ◽  
JoAnn Sonstein ◽  
Jeffrey L. Curtis ◽  
...  
Keyword(s):  
Immune Responses ◽  
Bacterial Infection ◽  
Innate Immune ◽  
Innate Immune Responses

Salmonella spv locus suppresses host innate immune responses to bacterial infection

2016 ◽  
Vol 58 ◽  
pp. 387-396 ◽  
Author(s):  
Shu-yan Wu ◽  
Li-dan Wang ◽  
Jin-ling Li ◽  
Guang-mei Xu ◽  
Mei-ling He ◽  
...  
Keyword(s):  
Immune Responses ◽  
Bacterial Infection ◽  
Innate Immune ◽  
Innate Immune Responses

scholarly journals Sequential MyD88-Independent and -Dependent Activation of Innate Immune Responses to Intracellular Bacterial Infection

Immunity ◽  
2003 ◽  
Vol 19 (6) ◽  
pp. 891-901 ◽  
Author(s):  
Natalya V Serbina ◽  
William Kuziel ◽  
Richard Flavell ◽  
Shizuo Akira ◽  
Barrett Rollins ◽  
...  
Keyword(s):  
Immune Responses ◽  
Bacterial Infection ◽  
Innate Immune ◽  
Innate Immune Responses
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