A Convenient Strategy for Remote C–H Bond Halogenation of 8-Aminoquinolines in the C5 Position

Synlett ◽  
2017 ◽  
Vol 28 (14) ◽  
pp. 1840-1844 ◽  
Author(s):  
Xiang-Xiang Chen ◽  
Jia-Xin Wang ◽  
Jiang-Tao Ren ◽  
Hu Xie ◽  
Yanxia Zhao ◽  
...  
Keyword(s):  
Transition Metal ◽  
Functional Groups ◽  
Metal Free ◽  
Highly Efficient

A highly efficient and convenient strategy has been developed for remote C–H bond halogenation of 8-aminoquinolines in good to excellent yields under transition-metal-free conditions. The reaction tolerates a variety of functional groups and can potentially be scaled up.

Transition-Metal-Free Synthesis of Trifluoromethylated Furans via a Bu3P-Mediated Tandem Acylation–Wittig Reaction

Synlett ◽  
2020 ◽  
Vol 31 (20) ◽  
pp. 2035-2038
Author(s):  
Wei Zhou ◽  
Maizhan Li
Keyword(s):  
Transition Metal ◽  
Functional Groups ◽  
Nucleophilic Addition ◽  
Wittig Reaction ◽  
Reaction Conditions ◽  
Metal Free ◽  
Highly Efficient ◽  
Intramolecular Wittig Reaction ◽  
High Yields

AbstractA highly efficient nucleophilic addition–O-acylation–intramolecular Wittig reaction of β-trifluoromethyl α,β-enones is disclosed. This strategy features mild reaction conditions and provides a practical transition-metal-free method to a set of biologically significant trifluoromethylated furans in high yields with diverse functional groups.

Deuterative cyclization of sulfanyl 1,6-diynes: complete and monodeuteration of functional groups on heterocycles

2015 ◽  
Vol 2 (3) ◽  
pp. 201-205 ◽  
Author(s):  
Yukiteru Ito ◽  
Mitsuhiro Yoshimatsu
Keyword(s):  
Transition Metal ◽  
Exchange Reaction ◽  
Functional Groups ◽  
Reductive Cyclization ◽  
Metal Free ◽  
Sodium Borodeuteride

Regioselective H/D exchange reaction of functional groups on heterocycles proceeded via a transition metal-free reductive cyclization of sulfanyl 1,6-diynes using sodium borodeuteride/ethanol-D1.

One-pot transition-metal free transamidation to sterically hindered amides

2018 ◽  
Vol 5 (20) ◽  
pp. 2950-2954 ◽  
Author(s):  
Weijie Guo ◽  
Jingjun Huang ◽  
Hongxiang Wu ◽  
Tingting Liu ◽  
Zhongfeng Luo ◽  
...  
Keyword(s):  
Transition Metal ◽  
Good Yield ◽  
One Pot ◽  
Metal Free ◽  
Highly Efficient ◽  
Sterically Hindered

A highly efficient one-pot transamidation of primary amides has been developed under transition-metal free conditions, generating a variety of amides including hindered amides in good yield (up to 86%) catalyzed by CsF.

scholarly journals K2S2O8-Promoted Aryl Thioamides Synthesis from Aryl Aldehydes Using Thiourea as the Sulfur Source

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2225 ◽  
Author(s):  
Yongjun Bian ◽  
Xingyu Qu ◽  
Yongqiang Chen ◽  
Jun Li ◽  
Leng Liu
Keyword(s):  
Transition Metal ◽  
Functional Groups ◽  
Sulfur Atom ◽  
Coupling Reaction ◽  
Sulfur Source ◽  
Atom Transfer ◽  
Free Condition ◽  
Metal Free ◽  
Aryl Aldehydes ◽  
Three Component Coupling

Thiourea as a sulfur atom transfer reagent was applied for the synthesis of aryl thioamides through a three-component coupling reaction with aryl aldehydes and N,N-dimethylformamide (DMF) or N,N-dimethylacetamide (DMAC). The reaction could tolerate various functional groups and gave moderate to good yields of desired products under the transition-metal-free condition.

Polythene glycol (PEG) as a reusable solvent system for the synthesis of 1,3,5-triazines via aerobic oxidative tandem cyclization of benzylamines and N-substituted benzylamines with amidines under transition metal-free conditions

2016 ◽  
Vol 18 (1) ◽  
pp. 144-149 ◽  
Author(s):  
Abhishek R. Tiwari ◽  
Bhalchandra M. Bhanage
Keyword(s):  
Transition Metal ◽  
Solvent System ◽  
Metal Free ◽  
Highly Efficient ◽  
Tandem Cyclization ◽  
Peg 600

A highly efficient protocol for the synthesis of 1,3,5-triazines from benzylamines and amidines in PEG-600 has been developed.

Transition-metal-free C–C bond cleavage and formation: efficient synthesis of 2,3-diarylimidazo[1,2-α]pyridines from 2-aminopyridines and alkynoates

RSC Advances ◽  
2016 ◽  
Vol 6 (89) ◽  
pp. 86464-86467 ◽  
Author(s):  
Zhengwang Chen ◽  
Yuelu Wen ◽  
Guotian Luo ◽  
Min Ye ◽  
Qinghao Wang
Keyword(s):  
Transition Metal ◽  
Bond Cleavage ◽  
Cyclization Reaction ◽  
Efficient Synthesis ◽  
Metal Free ◽  
Highly Efficient

A highly efficient transition-metal-free cyclization reaction for the synthesis of 2,3-diarylimidazo[1,2-α]pyridines is described.

scholarly journals Synthesis of Phenols via Metal-Free Hydroxylation of Aryl Boronic Acids with Aqueous TBHP

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Tanveer MahmadAlli Shaikh
Keyword(s):  
Transition Metal ◽  
Functional Groups ◽  
Boronic Acids ◽  
Aromatic Rings ◽  
Metal Free ◽  
Alternate Procedure

An alternate procedure for oxidative hydroxylation of aryl boronic acids with aqueous TBHP to access phenols is described. The protocol tolerated various functional groups substituted with aromatic rings. The reaction was performed in water and free from transition metal oxidants.

Visible-light-induced aerobic oxidative desulfurization of 2-mercaptobenzimidazoles via a sulfinyl radical

2020 ◽  
Vol 22 (17) ◽  
pp. 5594-5598 ◽  
Author(s):  
Mei Fu ◽  
Xiaochen Ji ◽  
Yongtong Li ◽  
Guo-Jun Deng ◽  
Huawen Huang
Keyword(s):  
Transition Metal ◽  
Visible Light ◽  
Oxidative Desulfurization ◽  
Metal Free ◽  
Highly Efficient ◽  
Sulfinyl Radical

A mild transition-metal-free non-toxic aerobic photoredox system was found to enable highly efficient desulfurization of 2-mercaptobenzimidazoles.

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