NHC-Catalyzed Synthesis of Benzazole-Phosphine Ligands under an Air Atmosphere

Synlett ◽  
2019 ◽  
Vol 30 (14) ◽  
pp. 1719-1724
Author(s):  
Wei Ren ◽  
Qian-Ming Zuo ◽  
Shang-Dong Yang
Keyword(s):  
Functional Group ◽  
Oxidative Cyclization ◽  
Phosphine Ligand ◽  
Phosphine Ligands ◽  
Cyclization Reaction ◽  
Atom Economy ◽  
Efficient Strategy ◽  
Air Atmosphere ◽  
Ligand Precursors ◽  
Ligand Synthesis

An efficient strategy for the synthesis of benzazole-phosphine ligand precursors via N-heterocyclic carbene catalyzed aerobic oxidative cyclization reaction has been performed. The reaction displays broad functional group tolerance and high atom economy, and the transformation has been further applied to benzazole-phosphine ligand synthesis.

NHC-catalyzed oxidative cyclization reaction for the synthesis of 3-substituted phthalides

2014 ◽  
Vol 12 (15) ◽  
pp. 2388-2393 ◽  
Author(s):  
So Won Youn ◽  
Hyoung Sub Song ◽  
Jong Hyub Park
Keyword(s):  
Michael Addition ◽  
Functional Group ◽  
Addition Reaction ◽  
Oxidative Cyclization ◽  
Cyclization Reaction ◽  
Michael Addition Reaction ◽  
Stereogenic Center

An efficient NHC-catalyzed domino oxidation/oxa-Michael addition reaction of 2-alkenylbenzaldehydes has been developed to afford 3-substituted phthalides bearing a C3-stereogenic center with a broad substrate scope and wide functional group tolerance.

Efficient Synthesis of Indole Derivatives Containing the Tetrazole Moeity Utilizing an Ugi-Azide Post-Transformation Strategy

Synlett ◽  
2018 ◽  
Vol 29 (14) ◽  
pp. 1892-1896 ◽  
Author(s):  
Saeed Balalaie ◽  
Ali Nikbakht ◽  
Fatemeh Baghestani ◽  
Frank Rominger
Keyword(s):  
Room Temperature ◽  
Functional Group ◽  
Cyclization Reaction ◽  
Indole Derivatives ◽  
Efficient Synthesis ◽  
Efficient Strategy ◽  
High Yields ◽  
Operational Simplicity ◽  
Transformation Strategy

An efficient strategy has been developed for the synthesis of indole derivatives containing the tetrazole moiety using a AuCl3-catalyzed cyclization reaction. The precursors of the cycloadduct were easily prepared by an Ugi-azide 4-CR in methanol at room temperature. The merit of this protocol lies in its operational simplicity, readily available starting materials, high yields of product, and good functional group tolerance.

Direct synthesis of indazole derivatives via Rh(iii)-catalyzed C–H activation of phthalazinones and allenes

2021 ◽  
Vol 19 (35) ◽  
pp. 7701-7705
Author(s):  
Chuanliu Yin ◽  
Tianshuo Zhong ◽  
Xiangyun Zheng ◽  
Lianghao Li ◽  
Jian Zhou ◽  
...  
Keyword(s):  
Catalytic System ◽  
Functional Group ◽  
Direct Synthesis ◽  
Atom Economy

An Rh(iii)-catalyzed annulation of phthalazinones and various allenes was developed, leading to the formation of indazole derivatives. This catalytic system exhibits excellent functional group tolerance and atom economy.

C(sp3)–H Functionalization with Isocyanides

2021 ◽  
Author(s):  
Weixiang Wang ◽  
Tianqi Liu ◽  
Chang-Hua Ding ◽  
Bin Xu
Keyword(s):  
Functional Group ◽  
Ugi Reaction ◽  
Atom Economy ◽  
Passerini Reaction

Isocyanide is well known for its multi-component reactions (MCR), such as Passerini reaction and Ugi reaction, with diverse molecular skeletons, high functional group compatibility, and good atom economy. With the...

Difunctionalization of the Isocyano Group: Atom-Economic ­Synthesis of Pyrimidinediones

Synlett ◽  
2018 ◽  
Vol 30 (03) ◽  
pp. 252-256 ◽  
Author(s):  
Jian Lang ◽  
Ye Wei
Keyword(s):  
Late Stage ◽  
Functional Group ◽  
Structural Diversity ◽  
Synthetic Methods ◽  
Chemical Bonds ◽  
Atom Economy

The exploration of synthetic methods involving the formation of new chemical bonds at both the nitrogen and carbons atoms of the isocyano group would largely enrich the structural diversity of compounds. Herein, we disclosed a silver-catalyzed difunctionalization of the isocyano group with cyclic oximes. This method can generate a great array of structurally novel and interesting pyrimidinediones and features excellent atom economy, good functional group compatibility, and amenability to late-stage modifications.

scholarly journals Cu/Pd-catalyzed borocarbonylative trifunctionalization of alkynes and allenes: synthesis of β-geminal-diboryl ketones

2021 ◽  
Author(s):  
Yang Yuan ◽  
Fu-Peng Wu ◽  
Anke Spannenberg ◽  
Xiao-Feng Wu
Keyword(s):  
Organic Synthesis ◽  
Functional Group ◽  
Building Blocks ◽  
Mechanistic Studies ◽  
Efficient Strategy ◽  
New Class ◽  
Reaction Proceeds

AbstractFunctionalized bisboryl compounds have recently emerged as a new class of synthetically useful building blocks in organic synthesis. Herein, we report an efficient strategy to synthesize β-geminal-diboryl ketones enabled by a Cu/Pd-catalyzed borocarbonylative trifunctionalization of readily available alkynes and allenes. This reaction promises to be a useful method for the synthesis of functionalized β-geminal-diboryl ketones with broad functional group tolerance. Mechanistic studies suggest that the reaction proceeds through borocarbonylation/hydroboration cascade of both alkynes and allenes.

scholarly journals A new class of platinum(ii) complexes with the phosphine ligand pta which show potent anticancer activity

2018 ◽  
Vol 5 (1) ◽  
pp. 39-53 ◽  
Author(s):  
M. D. Živković ◽  
J. Kljun ◽  
T. Ilic-Tomic ◽  
A. Pavic ◽  
A. Veselinović ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Phosphine Ligand ◽  
Phosphine Ligands ◽  
New Class

A series of 16 Pt(ii) complexes with 8-hydroxyquinolines and sulfoxide/phosphine ligands were synthetized, characterized and evaluated for cytotoxic and embryotoxic activity.

Convenient Synthesis of Oxazolo[5,4-h]pyrrolo[4,3,2-de]quino­lones via Hypervalent Iodine Mediated Intramolecular Oxidative Cyclization

Synthesis ◽  
2017 ◽  
Vol 28 (19) ◽  
pp. 4517-4522
Author(s):  
Li-Ping Sun ◽  
Chun-Meng Wang ◽  
Sheng-Wei Yang ◽  
Kai-Xiang Tang ◽  
Tian-Hong Gao ◽  
...  
Keyword(s):  
Functional Groups ◽  
Practical Method ◽  
Oxidative Cyclization ◽  
Hypervalent Iodine ◽  
Air Atmosphere ◽  
Convenient Synthesis ◽  
Reaction Proceeds ◽  
Intramolecular Oxidative Cyclization

A convenient and practical method has been developed for the synthesis of substituted oxazolo[5,4-h]pyrrolo[4,3,2-de]quinolones via the intramolecular oxidative cyclization by using PIFA as oxidant and TMSOTf as additive in DCE under an air atmosphere. The reaction proceeds in good yields and has good functional groups tolerance.

Direct Propargylation of ortho-Quinone Methides with Alkynyl Zinc Reagents: An Application to the One-Pot Synthesis of 2,3-Disubstituted Benzofurans

Synlett ◽  
2020 ◽  
Vol 31 (08) ◽  
pp. 818-822
Author(s):  
Hongjun Ren ◽  
Manman Sun ◽  
Jinyu Song ◽  
Lei Wang ◽  
Wenguang Yin ◽  
...  
Keyword(s):  
Transition Metal ◽  
Functional Group ◽  
Quinone Methides ◽  
One Pot ◽  
Metal Free ◽  
Efficient Strategy ◽  
One Pot Synthesis ◽  
Subsequent Cyclization ◽  
The One

A transition-metal-free propargylation of ortho-quinone methides (o-QMs) with alkynyl zinc reagents was achieved. A conjugate alkynylation of an o-QM and subsequent cyclization sequence in the presence of KOt-Bu for the synthesis of 2,3-disubstituted benzofurans in one pot was developed. This efficient strategy exhibits good functional-group compatibility and gives moderate to good yields. The present reaction might serve as an attractive method for the synthesis of polysubstituted benzofurans.

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