On the Role of Tumor Cell Surface in the Accumulation of Radioisotopes

1976 ◽  
Vol 15 (05) ◽  
pp. 242-245 ◽  
Author(s):  
R. Dermietzel ◽  
M. Heidbreder ◽  
L. J. Anghileri
Keyword(s):  
Cell Surface ◽  
Tumor Cell ◽  
Cell Membrane Permeability ◽  
Ascites Tumor ◽  
Cell Coat ◽  
Structural Modifications ◽  
Permeability Changes ◽  
Cell Surface Changes ◽  
Surface Changes

SummaryThe effects of electrical charge and structural modifications of the ascites tumor cell surface on the uptake of several radiocompounds have been investigated. Changes in its electrical surface charge provoke variations in the radioactivity incorporation which appear to be selective for chelated or ionic radioisotopes. The release of a part of the cell “coat” by EDTA affects profoundly the incorporation of radioisotopes in a process which seems to be related to cell membrane permeability changes. The relationships between cell surface changes and radiocompounds accumulation are discussed.

The Role of Cell Surface Changes in RNA Tumor Virus-transformed Cells

1974 ◽  
Vol 39 (0) ◽  
pp. 1181-1185 ◽  
Author(s):  
H. Bauer ◽  
R. Kurth ◽  
L. Rohrschneider ◽  
G. Pauli ◽  
R. R. Friis ◽  
...  
Keyword(s):  
Cell Surface ◽  
Transformed Cells ◽  
Tumor Virus ◽  
Cell Surface Changes ◽  
Surface Changes

Cell-surface changes during cytokinesis in a dipteran egg

1984 ◽  
Vol 28 (2) ◽  
pp. 101-108 ◽  
Author(s):  
Anders Lundquist ◽  
Bertil Löwkvist
Keyword(s):  
Cell Surface ◽  
Cell Surface Changes ◽  
Surface Changes

Neural induction and the structure of the target cell surface

Development ◽  
1982 ◽  
Vol 70 (1) ◽  
pp. 171-187
Author(s):  
A. M. Duprat ◽  
L. Gualandris ◽  
P. Rouge
Keyword(s):  
Cell Surface ◽  
Structural Integrity ◽  
Neural Induction ◽  
Active Role ◽  
Target Cells ◽  
Similar Treatment ◽  
Structural Modifications ◽  
Pleurodeles Waltl

Lectins (SBA and PSA) were used to provoke crowding and structural modifications of the presumptive ectoderm cell surface in order to investigate the role of the membrane organization of the competent target cells in neural induction. Are specific characteristics of the cell surface essential for this phenomenon to occur? From amphibian gastrulae, it is possible to obtain neural induction in vitro by association of presumptive ectoderm (target cells) with chordamesoderm (inductor tissue): 4 h of contact is sufficient in Pleurodeles waltl for transmission of the inductive signal. Very quickly, the treatment of the normal ectoderm by lectins (SBA-FITC or PSA-FITC) provoked surface modifications. Lectin-treatment (50 µg ml1−, 30 min) of presumptive ectoderm did not result in any neural induction. Lectin-treatment (50 µg ml1−, 30 min) of presumptive ectoderm previous to its association with the natural inductor for 4 h, disturbed the phenomenon: no induction. Similar treatment followed by association with the inductor for 24 h: induction. Treatment of SBA or PSA with their respective hapten inhibitors prior to addition to ectodermal cells completely blocked the suppressive effects on induction. The structural integrity of the membrane of competent target cells is necessary for neural induction to occur. The cell membrane could thus play, directly or indirectly, an active role in the specificity of this process

Cell surface changes accompanying aging in human diploid fibroblasts

1980 ◽  
Vol 127 (1) ◽  
pp. 143-157 ◽  
Author(s):  
Shinichi Aizawa ◽  
Youji Mitsui ◽  
Fumiko Kurimoto ◽  
Kohji Nomura
Keyword(s):  
Cell Surface ◽  
Diploid Fibroblasts ◽  
Human Diploid Fibroblasts ◽  
Cell Surface Changes ◽  
Surface Changes

Role of tumor cell surface lysosome-associated membrane protein-1 (LAMP1) and its associated carbohydrates in lung metastasis

2015 ◽  
Vol 141 (9) ◽  
pp. 1563-1574 ◽  
Author(s):  
Akhil Kumar Agarwal ◽  
Nithya Srinivasan ◽  
Rashmi Godbole ◽  
Shyam K. More ◽  
Srikanth Budnar ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Cell Surface ◽  
Tumor Cell ◽  
Lung Metastasis

Cell Surface Glycoconjugates of Euglena gracilis (Euglenozoa): Modifications under Potassium and Magnesium Deficiency

1997 ◽  
Vol 52 (1-2) ◽  
pp. 33-41
Author(s):  
Angelika Preisfeld ◽  
Gabriele Scholten-Beck ◽  
Hans Georg Ruppel
Keyword(s):  
Cell Surface ◽  
Protein Content ◽  
Alcian Blue ◽  
Euglena Gracilis ◽  
Magnesium Deficiency ◽  
Ruthenium Red ◽  
Complete Medium ◽  
Cell Surface Changes ◽  
Cell Surface Glycoconjugates ◽  
Surface Changes

Abstract Biochemical and ultrastructural examinations on the pellicle of autotrophically grown Eu­glena gracilis were carried out after three days under potassium and magnesium deficiency. Cell-surface changes were detected by lectin assay. Compared to cells grown in complete medium, deficient cells become larger in shape, accompanied by rising carbohydrate, chloro­phyll and protein content, bind more and other lectin molecules: an increase of mainly galactose and N-acetylgalactosamine receptors was observed. Investigations with the mucilage stains alcian blue and ruthenium red indicated that mucilaginous material is released under deficient conditions, whereas the control cells show a strong precipitate of these stains well inside the cells beneath the pellicle.

Cell surface changes of the presumptive ectoderm following neural-inducing treatment by concanavalin A

1981 ◽  
Vol 190 (6) ◽  
pp. 313-319 ◽  
Author(s):  
Kiyoko Yamazaki Yamamoto ◽  
Ruby Ozawa ◽  
Kenzo Takata ◽  
Junzoh Kitoh
Keyword(s):  
Cell Surface ◽  
Concanavalin A ◽  
Cell Surface Changes ◽  
Surface Changes
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