Sentinel lymph node diagnostic in prostate carcinoma: Part I: Technique and clinical evaluation

2002 ◽  
Vol 41 (02) ◽  
pp. 95-101 ◽  
Author(s):  
F. Wawroschek ◽  
H. Wengenmair ◽  
T. Wagner ◽  
J. Kopp ◽  
R. Dorn ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Gamma Probe ◽  
False Negative ◽  
Surgical Techniques ◽  
Pelvic Lymphadenectomy ◽  
Probe Measurement ◽  
Operation Theatre ◽  
Node Metastases

Summary Aim: Evaluation of the significance of lymphoscintigraphy and intraoperative probe measurement for the identification of the sentinel lymph node (SLN) in prostate cancer. Patients and method: In 117 patients with prostate cancer scintigrams in various projections were acquired till approximately 6 hours p.i. after ultrasound guided transrectal intraprostatic injection of 99mTc-Nanocoll ®. On the following day the SLNs were identified in the operation theatre with a gamma probe and removed. Pelvic standard lymph node dissection followed SLNE. Results: In three of 117 patients with preoperative lymphoscintigraphy no SLN was scintigraphically detectable. These three patients had antecedent transurethral resection of the prostate. In 113 of the residual 114 patients SLN could be intraoperatively localized. In the mean four SLNs per patient were removed. 28 of 117 patients had pelvic lymph node metastases. In 25 cases SLN were right-positive, in one false-negative and in one intraoperatively not detectable. In one patient we found macrometastasis of up to 4 cm diameter (one SLN was tumour positive). In 15 cases only the SLN was bearing tumour. Conclusion: The SLNE with preoperative lymphoscintigraphy and intraoperative gamma probe measurement is suitable for detecting lymph node metastasis in prostate cancer. SLNE is superior to the surgical techniques commonly used in pelvic lymphadenectomy.

DETECTION OF EARLY LYMPH NODE METASTASES IN PROSTATE CANCER BY LAPAROSCOPIC RADIOISOTOPE GUIDED SENTINEL LYMPH NODE DISSECTION

2005 ◽  
Vol 173 (6) ◽  
pp. 1943-1946 ◽  
Author(s):  
STEPHAN JESCHKE ◽  
THIAGARAJAN NAMBIRAJAN ◽  
KARL LEEB ◽  
JOSEF ZIEGERHOFER ◽  
WOLFGANG SEGA ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Node Dissection ◽  
Lymph Node Metastases ◽  
Sentinel Lymph Node Dissection ◽  
Node Dissection ◽  
Node Metastases

Intraoperative Radiochromoguided Mapping of Sentinel Lymph Node in Colon Cancer

2002 ◽  
Vol 88 (4) ◽  
pp. 352-353 ◽  
Author(s):  
P Nastro ◽  
M Sodo ◽  
CA Dodaro ◽  
S Gargiulo ◽  
W Acampa ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Regional Lymph Node ◽  
Gamma Probe ◽  
False Negative ◽  
Lymph Node Status ◽  
Blue Dye ◽  
Immunohistochemical Examination ◽  
Hematoxylin Eosin

Aims and Background The aim of our study was to assess the feasiblility of sentinel lymph node (SLN) detection in colon cancer using a radiochromoguided technique. The regional lymph node status is crucial for colorectal cancer staging and the stage of disease at the time of diagnosis is the main factor influencing therapeutic decision-making and patient survival. Methods and Study Design Between April and June 2001 eight patients with colon cancer were studied by radiochromoguided sentinel lymph node mapping. At the time of surgery 2 ml of patent blue dye was injected around the tumor, followed after 10 minutes by 2 ml of 99mTc-labeled albumin. After 30 minutes the SLN was identified by a gamma probe. Surgery was completed by standard resection. The SLN was processed for permanent hematoxylin and eosin staining and for immunohistochemical examination with anti-CEA and anti-cytokeratin antibodies. Results SLNs were identified in six patients; two were negative for metastasis by hematoxylin-eosin and immunohistochemical examination, two were positive for metastasis by both methods, and two were negative for metastasis by hematoxylin-eosin but positive by immunohistochemical examination. There were no false negative SLNs and no complications occurred. Conclusion The actual utility of SLN detection for prognostic purposes is still unknown, but intraoperative radiochromoguided SLN mapping is technically feasible in colon cancer, although it is associated with more technical difficulties than in breast cancer and malignant melanoma.

Sentinel Lymph Node Analysis in Squamous Carcinoma of the Oral Cavity and Oropharynx

2002 ◽  
Vol 88 (3) ◽  
pp. S58-S60 ◽  
Author(s):  
A Pastore ◽  
GD Turetta ◽  
A Tarabini ◽  
D Turetta ◽  
L Feggi ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Oral Cavity ◽  
Neck Dissection ◽  
Clinical Evidence ◽  
Gamma Probe ◽  
Squamous Carcinoma ◽  
Neoplastic Lesion ◽  
Node Metastases ◽  
Intraoperative Gamma Probe

Aims The aim of our study was to evaluate the usefulness and applicability of sentinel lymph node (SLN) identification in NO carcinomas of the oral cavity and oropharynx. Study design We carried out a prospective evaluation of SLN identification in 20 patients with oral cavity or oropharynx carcinomas with no clinical evidence of lymph node metastases. Methods Peritumoral infiltration with technetium-99-labeled nanocolloid followed by lymphoscintigrapy was carried out approximately 18 hours prior to surgery. A vital dye was injected intraoperatively and the SLN was identified with the aid of a gamma probe. All patients underwent routine neck dissection. Results While multiple radioactive nodes were generally identified on lymphoscintigraphy, the number of nodes ranging from one to five with variable degrees of uptake, intraoperative gamma probe scanning allowed the identification of a single more radioactive lymph node in 19 of the 20 patients. In only one patient did this method lead to the identification of two equally highly radioactive SLNs, with no uptake in the remaining nodes. All SLNs were ipsilateral to the neoplastic lesion. In 15 cases the SLN was tumor negative and so were the remaining nodes obtained by comprehensive neck dissection. In five cases the SLN was the only lymph node containing micrometastasis among those obtained by dissection. There were no instances of node positivity not involving the SLN. Conclusions Sentinel lymph node identification in ENT surgery may indicate intraoperatively if node metastases are present, thereby avoiding overtreatment in a substantial proportion of patients with NO carcinomas of the oral cavity or oropharynx.

Use of the gamma probe in sentinel lymph node biopsy in patients with prostate cancer

2005 ◽  
Vol 26 (12) ◽  
pp. 1081-1086 ◽  
Author(s):  
Neivo Silva ◽  
Carlos E. Anselmi ◽  
Osvaldo E. Anselmi ◽  
Rafael R. Madke ◽  
Angela Hunsche ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Gamma Probe ◽  
Lymph Node Biopsy ◽  
Node Biopsy

1600: Detection of Early Lymph Node Metastases in Prostate Cancer by Laparoscopic Radioisotope-Guided Sentinel Lymph Node Dissection

2005 ◽  
Vol 173 (4S) ◽  
pp. 433-433
Author(s):  
Stephan W. Jeschke ◽  
Thiagarajan Nambirajan ◽  
Karl Leeb ◽  
Peter Prammer ◽  
Josef Ziegerhofer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Node Dissection ◽  
Lymph Node Metastases ◽  
Sentinel Lymph Node Dissection ◽  
Node Dissection ◽  
Node Metastases

Sentinel lymph node in endometrial cancer

2007 ◽  
Vol 17 (5) ◽  
pp. 1113-1117 ◽  
Author(s):  
L.A.F Lopes ◽  
S. M Nicolau ◽  
F. F Baracat ◽  
E. C Baracat ◽  
W. J Gonçalves ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Nodes ◽  
Sentinel Node ◽  
Endometrial Carcinoma ◽  
Frozen Section ◽  
False Negative ◽  
Pelvic Lymphadenectomy ◽  
Clinical Staging ◽  
Blue Dye

The aim of this study was to evaluate the possibility of identifying the sentinel lymph node and involvement of neoplastic cells in patients with endometrial carcinoma limited to the uterus, and also its correlation with the conditions of other pelvic and para-aortic lymph nodes. Forty patients with endometrial carcinoma, clinical staging I and II, were submitted to complete surgical staging through laparotomy, as recommended by FIGO in 1988. The sentinel node was investigated using patent blue dye in the myometrial subserosa. The sentinel node was excised and submitted to frozen section examination of specimen, stained with hematoxylin and eosin (H&E). Afterward, selective bilateral para-aortic and pelvic lymphadenectomy, total hysterectomy with bilateral salpingo-oophorectomy were performed. The lymph nodes excised were examined by means of paraffin-embedded slices stained with H&E and of imunohistochemistry with antikeratin antibody AE1/AE3. The sentinel lymph node was identified in 77.5% of patients (31/40), and 16.1% (5/31) presented neoplastic involvement in the node. In 25 cases of negative sentinel node, 96% (24/25) had no neoplastic involvement, and 4% (1/25) had other lymph node affected (false negative). In nine cases with no sentinel node identified, 55.5% (5/9) had lymph node involvement. The results of this study allow us to conclude that it is possible to identify the sentinel node using the methods described, and the pathologic examination significantly represents the same conditions of other pelvic and para-aortic lymph nodes.

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