Quantitative Evaluation of Myocardial Stress/Rest 201TISPECT: Results of a ROI-Based Method in 108 Patients with CHD

1987 ◽  
Vol 26 (06) ◽  
pp. 234-240 ◽  
Author(s):  
H. Stirner ◽  
J. Dahl ◽  
R. Uebis ◽  
E. Kleinhans ◽  
M. Biedermann ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Quantitative Evaluation ◽  
Myocardial Infarctions ◽  
Myocardial Spect ◽  
Luminal Diameter ◽  
Myocardial Stress ◽  
Threshold Criterion ◽  
Combined Evaluation ◽  
Severity Of The Disease

ROI-based polar maps (33 ROIs) were employed to evaluate quantitatively stress/rest myocardial 201TI SPECT in 108 patients with angiographically proven coronary heart disease (CHD) in comparison with 30 controls. Sensitivity in detecting a CHD with stenoses of > 50% of luminal diameter was determined versus normal regional values (± 2.5 SD) employing vitality (VI) and wash-out corrected redistribution (RD). The method was evaluated referring to the severity of the disease, to the number of ROIs displaying changes [(a) 1 ROI, (b) >2 ROIs], to validity of VI, RD or a combination thereof, and for specificity. Wash-out values were found to depend on degree of stress individually achieved and thus were not used as a threshold criterion. Sensitivity in supply areas with old myocardial infarctions was 95% (a) and 86% (b), resp. With no infarction, it was 96% (a) and 79% (b), resp. VI in stenosis > 75% was more sensitive than RD. However, combined evaluation of VI and RD yielded sensitivities from 91-100% (a) and 77-94% (b), resp. for different main supply areas. In stenosis < 50% with normal VI, RD was positive in 18-31 %. Specificity turned out to be 91 % (a) and 97% (b), resp. We conclude that the method presented is reliable to quantify numerically 201TI kinetics in myocardial SPECT, aimed at detecting and describing CHD.

GW24-e3664 Study of quantitative evaluation of individual risk of coronary heart disease

Heart ◽  
2013 ◽  
Vol 99 (Suppl 3) ◽  
pp. A133.2-A133
Author(s):  
T Hunag ◽  
HM Yin ◽  
HY Gao ◽  
XQ Wang ◽  
MJ Li
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Quantitative Evaluation ◽  
Individual Risk

Coronary vasomotor and blood flow responses to isoflavone-intact soya protein in subjects with coronary heart disease or risk factors for coronary heart disease

2008 ◽  
Vol 115 (12) ◽  
pp. 353-359 ◽  
Author(s):  
Carolyn M. Webb ◽  
Christopher S. Hayward ◽  
Mark J. Mason ◽  
Charles D. Ilsley ◽  
Peter Collins
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Blood Flow ◽  
Heart Disease ◽  
Coronary Artery ◽  
Coronary Angiography ◽  
Coronary Circulation ◽  
Soya Protein ◽  
Short Term ◽  
Luminal Diameter

Results in animals suggest favourable coronary vasomotor actions of isoflavones; however, the effects of isoflavones on the human coronary circulation have not been determined. In the present study, we therefore investigated the effects of short-term isoflavone-intact soya protein ingestion on basal coronary arterial tone and stimulated vasoreactivity and blood flow in patients with CHD (coronary heart disease) or risk factors for CHD. Seventy-one subjects were randomized, double-blind, to isoflavone-intact soya protein [active; n=33, aged 58±8 years (mean±S.D.)] or isoflavone-free placebo (n=38, aged 61±8 years) for 5 days prior to coronary angiography. In 25 of these subjects, stimulated coronary blood flow was calculated from flow velocity, measured using intracoronary Doppler and coronary luminal diameter before and after intracoronary adenosine, ACh (acetylcholine) and ISDN (isosorbide dinitrate) infusions. Basal and stimulated coronary artery luminal diameters were measured using quantitative coronary angiography. Serum concentrations of the isoflavones genistein, daidzein and equol were increased by active treatment (P<0.001, P<0.001 and P=0.03 respectively). Basal mean luminal diameter was not significantly different between groups (active compared with placebo: 2.9±0.7 compared with 2.73±0.44 mm, P=0.31). There was no difference in luminal diameter, flow velocity and volume flow responses to adenosine, ACh or ISDN between groups. Active supplement had no effect on basal coronary artery tone or stimulated coronary vasoreactivity or blood flow compared with placebo. Our results suggest that short-term consumption of isoflavone-intact soya protein is neither harmful nor beneficial to the coronary circulation of humans with CHD or risk factors for CHD. These results are consistent with recent cautions placed on the purported health benefits of plant sterols.

Quantitative evaluation of capillaroscopic microvascular changes in patients with established coronary heart disease

2018 ◽  
Vol 150 (4) ◽  
pp. 131-137
Author(s):  
M. Esther Sanchez-Garcia ◽  
Irene Ramirez-Lara ◽  
Francisco Gomez-Delgado ◽  
Elena M. Yubero-Serrano ◽  
Ana Leon-Acuña ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Quantitative Evaluation ◽  
Microvascular Changes ◽  
Established Coronary Heart Disease

scholarly journals The influence of comorbidity on the severity of COVID-19 disease: A scoping review and meta-analysis

2020 ◽  
Author(s):  
Nazar Zaki ◽  
Elfadil Abdalla Mohamed ◽  
Sahar Ibrahim ◽  
Gulfaraz Khan
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Disease Severity ◽  
Clinical Symptoms ◽  
Meta Analysis ◽  
Machine Learning Techniques ◽  
Severity Of The Disease ◽  
Clinical Conditions ◽  
Random Effects Modeling

Abstract Background: A novel form of coronavirus disease (SARS-CoV-2) has spread rapidly across the world. What risk factors influence the severity of the disease is of considerable importance. Objectives: This research offers a systematic review and meta-analysis of the correlation between common clinical conditions and comorbidities and the severity of COVID-19. Methodology: Two independent researchers searched Europe PMC, Google Scholar, and PubMed databases for articles related to influence comorbidities have on the progress of the disease. A search engine was also created to screen a further 59,000 articles in COVID-19 Open Research Dataset (CORD-19). Random-effects modeling was used to pool 95% confidence intervals (CIs) and odds ratios (ORs). The significance of all comorbidities and clinical conditions to the severity of the disease was evaluated by employing machine-learning techniques. Publication bias was assessed by using funnel-plots and Egger’s-test. Heterogeneity was tested using I2. Results: The meta-analysis incorporated 12 studies spanning 4,101 confirmed COVID-19 patients who were admitted to Chinese hospitals. The prevalence of the most commonly associated co-morbidities and their corresponding odds ratio for disease severity were as follows: coronary heart disease (OR 2.97 [CI: 1.99-4.45], p < 0.0001), cancer (OR 2.65 [CI: 1.12-6.29], p < 0.03), cardiovascular disease (OR 2.89 [CI: 1.90-4.40], p < 0.0001), COPD (OR 3.24 [CI: 1.66-6.32], p = 0.0), and kidney disease (OR 2.2.4 [CI: 1.01-4.99], p = 0.05) with low or moderate level of heterogeneity. The most frequently exhibited clinical symptoms recorded during the course of admission were fever (OR 1.37 [CI: 1.01-1.86], p = 0.04), myalgia/fatigue (OR 1.31 [CI: 1.11-1.55], p = 0.0018), and dyspnea (OR 3.61, [CI: 2.57-5.06], p = <0.0001). No significant associations between disease severity and liver disease, smoking habits, and other clinical conditions, such as a cough, respiratory/ARDS, diarrhea or chest tightness/pain were found. The meta-analysis also revealed that the incubation period was positively associated with disease severity. Conclusion: Existing comorbidities, including COPD, cardiovascular disease, and coronary heart disease, increase the severity of COVID-19. Some studies found a statistically significant association between comorbidities such as diabetes and hypertension and disease severity. However, these studies may be biased due to substantial heterogeneity.

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