Continuous Renal Replacement Therapy for Treatment of Severe Attacks of Inborn Errors of Metabolism

AbstractSevere metabolic crises in children with inborn errors of metabolism can result in mortality or severe morbidities where continuous renal replacement therapy (CRRT) can be lifesaving. Clinical data, the pediatric risk of mortality (PRISM) scores calculated in the first 24 hours, and pediatric logistic organ dysfunction (PELOD) scores calculated in the last 24 hours before CRRT, were studied. Overall, CRRT was successful in restoring metabolic balance in 72% of patients. PELOD scores before CRRT were lower in survivors (p = 0.02). Despite numerous comorbid factors, CRRT can be used effectively in management of metabolic crises. Early intervention with this therapy before occurrence of complications must be targeted.

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Inborn Errors of Metabolism and Continuous Renal Replacement Therapy

Critical Care Nephrology ◽

10.1016/b978-1-4160-4252-5.50307-5 ◽

2009 ◽

pp. 1630-1633

Author(s):

Scott Walters ◽

Patrick D. Brophy

Keyword(s):

Renal Replacement Therapy ◽

Continuous Renal Replacement Therapy ◽

Replacement Therapy ◽

Inborn Errors Of Metabolism ◽

Inborn Errors

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Extracorporeal therapies in pediatric organ dysfunction: Extracorporeal membrane oxygenation and continuous renal replacement therapy*

Pediatric Critical Care Medicine ◽

10.1097/01.pcc.0000269384.28300.31 ◽

2007 ◽

Vol 8 (4) ◽

pp. 405-406 ◽

Cited By ~ 3

Author(s):

Timothy E. Bunchman

Keyword(s):

Renal Replacement Therapy ◽

Extracorporeal Membrane Oxygenation ◽

Continuous Renal Replacement Therapy ◽

Replacement Therapy ◽

Organ Dysfunction ◽

Membrane Oxygenation

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Successful Treatment of Crush Syndrome Complicated with Multiple Organ Dysfunction Syndrome Using Hybrid Continuous Renal Replacement Therapy

Blood Purification ◽

10.1159/000227786 ◽

2009 ◽

Vol 28 (3) ◽

pp. 175-180 ◽

Cited By ~ 7

Author(s):

Qin Wei ◽

Su Baihai ◽

Fu Ping ◽

Chen Xiaolei ◽

Li Jing ◽

...

Keyword(s):

Renal Replacement Therapy ◽

Continuous Renal Replacement Therapy ◽

Replacement Therapy ◽

Organ Dysfunction ◽

Multiple Organ Dysfunction Syndrome ◽

Successful Treatment ◽

Multiple Organ ◽

Crush Syndrome ◽

Multiple Organ Dysfunction

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A Case of Application of Bedside Continuous Renal Replacement Therapy on Treatment of MODS Caused by Fish Bile Poisoning

Journal of Pharmaceutics and Therapeutics ◽

10.18314/jpt.v3i1.132 ◽

2017 ◽

Vol 3 (1) ◽

Author(s):

Qi Zou ◽

Cheng Liu ◽

Gang Yu ◽

Ximing Deng ◽

Meiling Yu

Keyword(s):

Renal Replacement Therapy ◽

Continuous Renal Replacement Therapy ◽

Replacement Therapy ◽

Organ Dysfunction ◽

Balance Control ◽

The Body ◽

Whole Body ◽

Electrolyte Balance ◽

Liver And Kidney ◽

Fish Bile

One case of 54 years old female patient was admitted to hospital due to vomiting and diarrhea for 3 days and abnormal renal function for 1 day. The patient appeared repeatedly vomiting and watery stools 6 hours after eating 2 grain of raw carp fish bile and gradually appeared oliguresis, whole body skin yellow dye and fever symptoms. The condition of patient had no improvement after visiting the emergency department of local county hospital. She was checked in department of nephropathy in our hospital for further diagnosis and treatment. Because the patient's condition was serious and the function of liver and kidney was damaged, diagnosed as severe multiple organ dysfunction syndrome (MODS), she was transferred to ICU rescue to protect the liver, maintain water and electrolyte balance, control blood sugar, improve the circulation and give other drug treatments and actively carry out bedside continuous renal replacement therapy. Then the body temperature and hemogram of the patients became normal, liver and kidney function improved obviously, urinary production became normal, skin yellow dye faded and vital signs became stable. The successful treatment of this patient indicated that bedside continuous renal replacement therapy can not only have a good support for the kidneys but also reduce the waterfall effect of inflammatory of patients with severe MODS, which has great therapeutic effect on the multi organ dysfunction caused by fish bile poisoning.

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