Efficient Synthesis of 5-Trifluoromethylthio-1,2,3-Triazoles: One-Pot Multicomponent Reaction from Elemental Sulfur and TMSCF3

Synthesis ◽  
2019 ◽  
Vol 52 (02) ◽  
pp. 304-310 ◽  
Author(s):  
Lin-Lin Zhang ◽  
Meng-Tian Li ◽  
Liang-Liang Shen ◽  
Qin-Pei Wu
Keyword(s):  
Multicomponent Reaction ◽  
Elemental Sulfur ◽  
Efficient Synthesis ◽  
One Pot ◽  
Mild Conditions ◽  
Multistep Reaction ◽  
Easy Operation

A sequential multistep reaction toward 5-trifluoromethyl­thio-1,2,3-triazoles has been established, starting from alkynes, organo­azides, S8, and (trifluoromethyl)trimethylsilane (TMSCF3). This reaction features mild conditions, easy operation, and readily available substrates.

Efficient Synthesis of Diverse 5-Thio- or 5-Selenotriazoles: One-Pot Multicomponent Reaction from Elemental Sulfur or Selenium

Synthesis ◽  
2019 ◽  
Vol 51 (22) ◽  
pp. 4170-4182 ◽  
Author(s):  
Lin-Lin Zhang ◽  
Ya-Ting Li ◽  
Ting Gao ◽  
Sha-Sha Guo ◽  
Bei Yang ◽  
...  
Keyword(s):  
Elemental Sulfur ◽  
Functional Group ◽  
High Efficiency ◽  
Efficient Synthesis ◽  
One Pot ◽  
Mild Conditions ◽  
Ligand Free ◽  
Multistep Reaction ◽  
Easy Operation

A sequential multistep reaction toward 5-thio- or 5-selenotriazoles has been established by generation of both copper(I) triazolides and sulfenylating or selenylating agents in situ, starting from elemental sulfur or selenium. This reaction features mild conditions, readily available and broad-scope substrates, good functional group compatibility, high efficiency and regioselectivity, easy operation, and ligand-free CuI.

Efficient Synthesis of Trialkyl 3-Phenylbuta-1,3-diene-1,2,4-tricarboxylates by a Novel One-Pot Multicomponent Reaction

2007 ◽  
Vol 90 (2) ◽  
pp. 392-394 ◽  
Author(s):  
Issa Yavari ◽  
Loghman Moradi ◽  
Ako Mokhtarporyani-Sanandej ◽  
Anvar Mirzaei
Keyword(s):  
Multicomponent Reaction ◽  
Efficient Synthesis ◽  
One Pot

ChemInform Abstract: Glycine-Catalyzed Efficient Synthesis of Pyranopyrazoles via One-Pot Multicomponent Reaction.

ChemInform ◽  
2011 ◽  
Vol 42 (12) ◽  
pp. no-no
Author(s):  
M. B. Madhusudana Reddy ◽  
V. P. Jayashankara ◽  
M. A. Pasha
Keyword(s):  
Multicomponent Reaction ◽  
Efficient Synthesis ◽  
One Pot

Convenient and efficient synthesis of disubstituted piperazine derivatives by catalyst-free, atom-economical and tricomponent domino reactions

RSC Advances ◽  
2015 ◽  
Vol 5 (14) ◽  
pp. 10768-10772 ◽  
Author(s):  
Hong-Ru Dong ◽  
Zi-Bao Chen ◽  
Rong-Shan Li ◽  
Heng-Shan Dong ◽  
Zhi-Xiang Xie
Keyword(s):  
Free Atom ◽  
Domino Reactions ◽  
Efficient Synthesis ◽  
One Pot ◽  
Diversity Oriented Synthesis ◽  
Mild Conditions ◽  
Catalyst Free ◽  
Piperazine Derivatives ◽  
High Yields

One-pot, atom-economical, catalyst-free and tri-component domino reactions are applied to diversity-oriented synthesis (DOS) of disubstituted piperazine derivatives under mild conditions with moderate to high yields.

scholarly journals Thiol-free chemoenzymatic synthesis of β-ketosulfides

2019 ◽  
Vol 15 ◽  
pp. 378-387
Author(s):  
Adrián A Heredia ◽  
Martín G López-Vidal ◽  
Marcela Kurina-Sanz ◽  
Fabricio R Bisogno ◽  
Alicia B Peñéñory
Keyword(s):  
Multicomponent Reaction ◽  
Chemical Diversity ◽  
Chemoenzymatic Synthesis ◽  
Selective Synthesis ◽  
High Chemical ◽  
One Pot ◽  
Mild Conditions ◽  
Set Up ◽  
Sulfur Donor

A preparation of β-ketosulfides avoiding the use of thiols is described. The combination of a multicomponent reaction and a lipase-catalysed hydrolysis has been developed in order to obtain high chemical diversity employing a single sulfur donor. This methodology for the selective synthesis of a set of β-ketosulfides is performed under mild conditions and can be set up in one-pot two-step and on a gram-scale.

scholarly journals Application of One-Pot Three-Component Condensation Reaction for the Synthesis of New Organophosphorus–Sulfur Macrocycles

Synlett ◽  
2018 ◽  
Vol 29 (11) ◽  
pp. 1496-1501 ◽  
Author(s):  
J. Woollins ◽  
Guoxiong Hua ◽  
David Cordes ◽  
Alexandra Slawin
Keyword(s):  
Multicomponent Reaction ◽  
Room Temperature ◽  
Condensation Reaction ◽  
Synthesis Method ◽  
Membered Ring ◽  
One Pot ◽  
X Ray ◽  
Efficient Approach ◽  
Mild Conditions ◽  
Sulfur Heterocycles

An efficient approach has been developed for the synthesis of new phosphorus–sulfur heterocycles by a one-pot three-component condensation reaction of a four-membered-ring thionation reagent [Lawesson’s reagent or its ferrocene analogue (2,4-diferrocenyl-1,3,2,4-diathiadiphosphetane 2,4-disulfide)], an alkane- or arenedithiol, and a dihaloalkane at room temperature in the presence of triethylamine. The simple synthesis method with mild conditions (room temperature and normal reactant concentrations) enhances further the application of the multicomponent reaction in the preparation of novel phosphorus–sulfur heterocycles. Six representative X-ray structures confirmed the formation of these macrocycles.

scholarly journals Eosin Y-catalyzed visible-light-mediated aerobic oxidative cyclization of N,N-dimethylanilines with maleimides

2015 ◽  
Vol 11 ◽  
pp. 425-430 ◽  
Author(s):  
Zhongwei Liang ◽  
Song Xu ◽  
Wenyan Tian ◽  
Ronghua Zhang
Keyword(s):  
Visible Light ◽  
Oxidative Cyclization ◽  
Eosin Y ◽  
Efficient Synthesis ◽  
One Pot ◽  
Bond Functionalization ◽  
Metal Free ◽  
Mild Conditions ◽  
Simple Strategy ◽  
Air Atmosphere

A novel and simple strategy for the efficient synthesis of the corresponding tetrahydroquinolines from N,N-dimethylanilines and maleimides using visible light in an air atmosphere in the presence of Eosin Y as a photocatalyst has been developed. The metal-free protocol involves aerobic oxidative cyclization via sp3 C–H bond functionalization process to afford good yields in a one-pot procedure under mild conditions.

Efficient Synthesis of Trialkyl 3-Phenylbuta-1,3-diene-1,2,4-tricarboxylates by a Novel One-Pot Multicomponent Reaction.

ChemInform ◽  
2007 ◽  
Vol 38 (24) ◽  
Author(s):  
Issa Yavari ◽  
Loghman Moradi ◽  
Ako Mokhtarporyani-Sanandej ◽  
Anvar Mirzaei
Keyword(s):  
Multicomponent Reaction ◽  
Efficient Synthesis ◽  
One Pot
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