Inspiratory muscle dysfunction with restrictive lung disease in congenital heart disease: linked to IL-6 and associated with exercise intolerance

2020 ◽  
Author(s):  
J Spießhöfer ◽  
S Orwat ◽  
HJ Kabitz ◽  
H Baumgartner ◽  
M Spieker ◽  
...  
2012 ◽  
Vol 8 (3) ◽  
pp. 246-254 ◽  
Author(s):  
Salil Ginde ◽  
Peter J. Bartz ◽  
Garick D. Hill ◽  
Michael J. Danduran ◽  
Julie Biller ◽  
...  

2006 ◽  
Vol 24 (4) ◽  
pp. 641-660 ◽  
Author(s):  
Konstantinos Dimopoulos ◽  
Gerhard-Paul Diller ◽  
Massimo F. Piepoli ◽  
Michael A. Gatzoulis

2021 ◽  
Author(s):  
Satomi Mori ◽  
Koji Tanoue ◽  
Hiroyuki Shimizu ◽  
Hiroyuki Nagafuchi ◽  
Ki‐Sung Kim ◽  
...  

2021 ◽  
Vol 10 (6) ◽  
pp. 3762-3765
Author(s):  
Ragini Dadgal

Congenital heart disease consists of various conditions including tetralogy of Fallot, ventricular septal defect, Epstein’s anomaly, single ventricle, etc. Among these single ventricles is one of the gravest forms of cyanotic congenital heart disease. The cardiac diagnosis is associated with an increased risk of stroke among children. Pediatric arterial ischemic stroke (AIS) is an important cause of neurologic disease in children causing disability. The 14-year-old patient came to the hospital was presented with left side hemiplegia with severe exercise intolerance due to congenital heart disease. The patient has been advised to undergo Fontan procedure for single-ventricle condition 3 years back, but due to poor socioeconomic status, parents of patients refused to do so. The primary goal was to improve bed mobility and trunk balance without developing symptoms of exercise intolerance. The intervention was started with deep and segmental breathing exercises. Proprioceptive neuromuscular facilitation and constrained induced movement therapy were added in the program in addition to passive and active movements, bed mobility, functional reeducation, trunk control exercises, and balance exercises. Combinations of all of the above therapeutic approaches lead to increased functional independence in the patient. This case reports the effectiveness of a rehabilitation program for pediatric arterial ischemic stroke with preventive guidelines for exercise intolerance.


2020 ◽  
pp. 3695-3710
Author(s):  
Nicholas W. Morrell

Symptoms of unexplained exertional breathlessness or symptoms out of proportion to coexistent heart or lung disease should alert the clinician to the possibility of pulmonary hypertension, and the condition should be actively sought in patients with known associated conditions, such as scleroderma, hypoxic lung disease, liver disease, or congenital heart disease. Heterozygous germ-line mutations in the gene encoding the bone morphogenetic protein type II receptor (BMPR2) are found in over 70% of families with pulmonary arterial hypertension. Pulmonary hypertension is defined as a mean pulmonary arterial pressure greater than 25 mm Hg at rest, and may be due to increased pulmonary vascular resistance (e.g. pulmonary arterial hypertension), increased transpulmonary blood flow (e.g. congenital heart disease), or increased pulmonary venous pressures (e.g. mitral stenosis). Exercise tolerance and survival in pulmonary hypertension is ultimately related to indices of right heart function, such as cardiac output.


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