Palladium(II)-Catalyzed Three-Component Tandem Cyclization Reaction for the One-Pot Assembly of 4-Arylquinazolines

Synthesis ◽  
2020 ◽  
Author(s):  
Guolin Zhang ◽  
Yongping Yu ◽  
Zijuan Wang ◽  
Wenteng Chen ◽  
Chang He
Keyword(s):  
Bond Formation ◽  
Cascade Reaction ◽  
Cyclization Reaction ◽  
One Pot ◽  
Tandem Cyclization ◽  
The One

AbstractA one-pot method for joining three separate components leading to an assortment of 4-arylquinazolines (27 examples) in good to excellent yields is described. The method consists of a palladium(II)-catalyzed­ cascade reaction involving C(sp)–C(sp2) coupling followed by intramolecular C–N bond formation. The reaction was readily scaled up to gram quantity and successfully applied to the synthesis of a translocator­ protein (TSPO) ligand.

A novel one-pot method for the synthesis of substituted furopyridines: iodine-mediated oxidation of enaminones by tandem metal-free cyclization

2015 ◽  
Vol 51 (13) ◽  
pp. 2573-2576 ◽  
Author(s):  
Rulong Yan ◽  
Xiaoni Li ◽  
Xiaodong Yang ◽  
Xing Kang ◽  
Likui Xiang ◽  
...  
Keyword(s):  
Bond Formation ◽  
Cyclization Reaction ◽  
One Pot ◽  
Metal Free ◽  
Tandem Cyclization ◽  
Mediated Oxidation

A novel iodine-mediated oxidative tandem cyclization reaction of simple enaminones has been developed for the synthesis of substituted furopyridines through C–C/C–N/C–O bond formation in a one-pot procedure.

Nano-cuprous oxide catalyzed one-pot synthesis of a carbazole-based STAT3 inhibitor: a facile approach via intramolecular C–N bond formation reactions

RSC Advances ◽  
2016 ◽  
Vol 6 (43) ◽  
pp. 36775-36785 ◽  
Author(s):  
C. P. Baburajeev ◽  
Chakrabhavi Dhananjaya Mohan ◽  
Govindagouda S. Patil ◽  
Shobith Rangappa ◽  
Vijay Pandey ◽  
...  
Keyword(s):  
Cuprous Oxide ◽  
Inhibitory Activity ◽  
Bond Formation ◽  
One Pot ◽  
Carbazole Derivatives ◽  
One Pot Synthesis ◽  
The One ◽  
New Compounds ◽  
Bond Formation Reactions

In this study, we report the one-pot synthesis of substituted carbazole derivatives using nano cuprous oxide as a catalyst and demonstrated the STAT3 inhibitory activity of new compounds.

Cu-ZSM5 as reusable catalyst for the one-pot, odorless and ligand-free C-S bond formation

2016 ◽  
Vol 86 ◽  
pp. 108-112 ◽  
Author(s):  
Kamran Amiri ◽  
Amin Rostami ◽  
Saadi Samadi ◽  
Abed Rostami
Keyword(s):  
Bond Formation ◽  
Reusable Catalyst ◽  
One Pot ◽  
Ligand Free ◽  
The One

The one-pot synthesis of quinolines via Co(iii)-catalyzed C–H activation/carbonylation/cyclization of anilines

2017 ◽  
Vol 15 (43) ◽  
pp. 9061-9065 ◽  
Author(s):  
Xuefeng Xu ◽  
Yurong Yang ◽  
Xin Chen ◽  
Xu Zhang ◽  
Wei Yi
Keyword(s):  
Cascade Reaction ◽  
One Pot ◽  
One Pot Synthesis ◽  
The One

A new and versatile Co(iii)-catalyzed C–H activation/carbonylation/cyclization cascade reaction has been disclosed.

New Convenient Strategy for Annulation of Pyrimidines to Thiophenes or Furans via the One-pot Multistep Cascade Reaction of 1H-Tetrazoles with Aliphatic Amines

2015 ◽  
Vol 17 (7) ◽  
pp. 399-403 ◽  
Author(s):  
Nazariy T. Pokhodylo ◽  
Olga Ya. Shyyka ◽  
Vasyl S. Matiychuk ◽  
Mykola D. Obushak
Keyword(s):  
Cascade Reaction ◽  
Aliphatic Amines ◽  
One Pot ◽  
The One

A green approach for the one-pot multi-component synthesis of N-substituted γ, δ and ε-lactams involving C–N bond formation catalyzed by FeCl3

RSC Advances ◽  
2013 ◽  
Vol 3 (45) ◽  
pp. 23035 ◽  
Author(s):  
Venkatesan Sathesh ◽  
Munusamy Sathishkumar ◽  
Gunasekar Ramachandran ◽  
Ravindranath S. Rathore ◽  
Kulathu Iyer Sathiyanarayanan
Keyword(s):  
Bond Formation ◽  
One Pot ◽  
Green Approach ◽  
The One

scholarly journals In Situ Growth of ZIF-8 Nanocrystals on the Pore Walls of 3D Ordered Macroporous TiO2 for a One-Pot Cascade Reaction

Catalysts ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 533
Author(s):  
Jing Chen ◽  
Yingchun Guo ◽  
Tengteng Kang ◽  
Xingchi Liu ◽  
Xiaomei Wang ◽  
...  
Keyword(s):  
Crystallization Process ◽  
Knoevenagel Condensation ◽  
Cascade Reaction ◽  
Multifunctional Composites ◽  
One Pot ◽  
Visible Light Absorption ◽  
Multiple Components ◽  
Ordered Macroporous ◽  
The One

It is wise to mimic a bioinspired system to design a nanoreactor as a catalyst containing multiple components for a cascade reaction. Here, we report the uniform growth of well-dispersed nano-scale ZIF-8 crystals on the pore walls of 3DOM TiO2 via the TEA-assisted crystallization process. The UV-vis spectra indicate that the ZIF-8 photosensitizer can extend the visible-light absorption of 3DOM TiO2. The obtained nanoreactor can efficiently catalyze the one-pot aromatic alcohol oxidization and Knoevenagel condensation cascade reaction for larger molecules. This work offers an important strategy for preparing semiconductor–MOF multifunctional composites with a spatially separated compartmentation for the cascade reaction.

An Efficient Synthesis of New 7-Trifluoromethyl-2,5-disubstituted Pyrazolo[1,5-a]pyrimidines

Synthesis ◽  
2018 ◽  
Vol 50 (08) ◽  
pp. 1675-1686 ◽  
Author(s):  
Mohamed Abarbri ◽  
Badr Jismy ◽  
Hassan Allouchi ◽  
Gérald Guillaumet ◽  
Mohamed Akssira
Keyword(s):  
Bond Activation ◽  
Bond Formation ◽  
Building Blocks ◽  
Synthetic Route ◽  
Efficient Synthesis ◽  
One Pot ◽  
One Pot Synthesis ◽  
Biological Interest ◽  
The One

A novel two-step synthesis of trifluoromethylated 3,5-disubstituted pyrazolo[1,5-a]pyrimidines is reported from 3-aminopyrazoles and ethyl 4,4,4-trifluorobut-2-ynoate. The synthetic route begins with the one-pot synthesis of 7-trifluoromethylated pyrazolo[1,5-a]pyrimidin-5-ones by condensation of 3-aminopyrazoles with a fluorinated alkyne. The products obtained are used as building blocks to synthesize directly, with excellent yields via C–O bond activation, a library of new fluorinated 3,5-disubstituted pyrazolo[1,5-a]pyrimidines of biological interest. This operation efficiently allows C–C, C–N and C–S bond formation.

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