Nano-cuprous oxide catalyzed one-pot synthesis of a carbazole-based STAT3 inhibitor: a facile approach via intramolecular C–N bond formation reactions

In this study, we report the one-pot synthesis of substituted carbazole derivatives using nano cuprous oxide as a catalyst and demonstrated the STAT3 inhibitory activity of new compounds.

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An efficient and convenient protocol for the synthesis of tetracyclic isoindolo[1,2-a]quinazoline derivatives

RSC Advances ◽

10.1039/c5ra28097d ◽

2016 ◽

Vol 6 (43) ◽

pp. 36599-36601 ◽

Cited By ~ 9

Author(s):

M. V. Madhubabu ◽

R. Shankar ◽

Satish. S. More ◽

Mandava V. Basaveswara Rao ◽

U. K. Syam Kumar ◽

...

Keyword(s):

Lewis Acid ◽

Bond Formation ◽

One Pot ◽

One Pot Synthesis ◽

Quinazoline Derivatives ◽

Bond Formation Reactions

A convenient and one-pot synthesis of tetracyclic isoindolo [1,2-a]quinazoline derivatives via Lewis acid mediated sequential C–N bond formation reactions is reported.

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An Efficient Synthesis of New 7-Trifluoromethyl-2,5-disubstituted Pyrazolo[1,5-a]pyrimidines

Synthesis ◽

10.1055/s-0036-1591752 ◽

2018 ◽

Vol 50 (08) ◽

pp. 1675-1686 ◽

Cited By ~ 7

Author(s):

Mohamed Abarbri ◽

Badr Jismy ◽

Hassan Allouchi ◽

Gérald Guillaumet ◽

Mohamed Akssira

Keyword(s):

Bond Activation ◽

Bond Formation ◽

Building Blocks ◽

Synthetic Route ◽

Efficient Synthesis ◽

One Pot ◽

One Pot Synthesis ◽

Biological Interest ◽

The One

A novel two-step synthesis of trifluoromethylated 3,5-disubstituted pyrazolo[1,5-a]pyrimidines is reported from 3-aminopyrazoles and ethyl 4,4,4-trifluorobut-2-ynoate. The synthetic route begins with the one-pot synthesis of 7-trifluoromethylated pyrazolo[1,5-a]pyrimidin-5-ones by condensation of 3-aminopyrazoles with a fluorinated alkyne. The products obtained are used as building blocks to synthesize directly, with excellent yields via C–O bond activation, a library of new fluorinated 3,5-disubstituted pyrazolo[1,5-a]pyrimidines of biological interest. This operation efficiently allows C–C, C–N and C–S bond formation.

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One-pot synthesis of novel functionalized benzodiazepines via three-component or domino reactions

New Journal of Chemistry ◽

10.1039/c8nj04893b ◽

2018 ◽

Vol 42 (24) ◽

pp. 20032-20040 ◽

Cited By ~ 5

Author(s):

Yue-Wei Sun ◽

Lan-Zhi Wang

Keyword(s):

Domino Reactions ◽

One Pot ◽

Highly Efficient ◽

One Pot Synthesis ◽

The One ◽

New Compounds

A simple and highly efficient protocol for the one-pot synthesis of novel benzodiazepines, which fused tricyclic or tetracyclic systems containing aryl, carboxyl, ester and acyl groups, was developed. Libraries of 40 new compounds were successfully synthesized via three-component or domino reactions by using a mild catalyst (γ-Fe2O3@SiO2/CeCl3) in good to excellent yields (82–97%).

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An Overview of the One-pot Synthesis of Imidazolines

Current Organic Chemistry ◽

10.2174/1385272824999201001153735 ◽

2020 ◽

Vol 24 (20) ◽

pp. 2341-2355

Author(s):

Thaipparambil Aneeja ◽

Sankaran Radhika ◽

Mohan Neetha ◽

Gopinathan Anilkumar

Keyword(s):

Asymmetric Catalysis ◽

Organic Compounds ◽

Ring Opening ◽

Ecological Impact ◽

Chiral Auxiliary ◽

One Pot ◽

One Pot Synthesis ◽

The One ◽

Synthetic Intermediate ◽

Heterocyclic Moiety

One-pot syntheses are a simple, efficient and easy methodology, which are widely used for the synthesis of organic compounds. Imidazoline is a valuable heterocyclic moiety used as a synthetic intermediate, chiral auxiliary, chiral catalyst and a ligand for asymmetric catalysis. Imidazole is a fundamental unit of biomolecules that can be easily prepared from imidazolines. The one-pot method is an impressive approach to synthesize organic compounds as it minimizes the reaction time, separation procedures, and ecological impact. Many significant one-pot methods such as N-bromosuccinimide mediated reaction, ring-opening of tetrahydrofuran, triflic anhydrate mediated reaction, etc. were reported for imidazoline synthesis. This review describes an overview of the one-pot synthesis of imidazolines and covers literature up to 2020.

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