Comparison of ABR Stimuli for the Early Detection of Ototoxicity: Conventional Clicks Compared with High Frequency Clicks and Single Frequency Tonebursts

2003 ◽  
Vol 14 (05) ◽  
pp. 239-250 ◽  
Author(s):  
Stephen A. Fausti ◽  
Christopher L. Flick ◽  
Alison M. Bobal ◽  
Roger M. Ellingson ◽  
James A. Henry ◽  
...  
Keyword(s):  
Early Detection ◽  
High Frequency ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
Single Frequency ◽  
Efficient Manner ◽  
High Frequencies ◽  
Objective Testing ◽  
Testing Methodology

Effective objective testing methodology is needed for early detection of the effects of ototoxicity on hearing in patients. The requirements for such testing include responses that are: 1) reliable across test sessions; 2) sensitive to ototoxic change (> 8 kHz), and 3) recordable in a time-efficient manner. Auditory brainstem responses (ABR) appear well suited to this task however, conventional clicks stimulate primarily mid-frequencies (1-4 kHz) and high frequency tonebursts require too much time. We hypothesized that delivery of a band of high frequencies (a high frequency "click"), would elicit reliable and useful ABRs. In the current study, flat and sloped HF (high frequency) clicks with a bandwidth of 8-14 kHz were used. The purpose was to compare brainstem responses elicited by tonebursts, two HF clicks and conventional clicks. The results show that the reliability of responses to the HF clicks were comparable to the tonebursts and further, both HF clicks produced responses slightly larger than tonebursts.

Auditory Brainstem Responses in a Case of High-Frequency Conductive Hearing Loss

1985 ◽  
Vol 50 (4) ◽  
pp. 346-350 ◽  
Author(s):  
Michael P. Gorga ◽  
Jan K. Reiland ◽  
Kathryn A. Beauchaine
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Conductive Hearing Loss ◽  
Auditory Brainstem ◽  
Intensity Function ◽  
Auditory Brainstem Responses ◽  
Normal Limits ◽  
Interpeak Latency ◽  
Lower Limits ◽  
Conductive Hearing

Click-evoked auditory brainstem responses were measured in a patient with high-frequency conductive hearing loss. As is typical in cases of conductive hearing loss, Wave I latency was prolonged beyond normal limits. Interpeak latency differences were just below the lower limits of the normal range. The Wave V latency-intensity function, however was abnormally steep. This pattern is explained by the hypothesis that the slope of the latency-intensity function is determined principally by the configuration of the hearing loss. In cases of high-frequency hearing loss (regardless of the etiology), the response may be dominated by more apical regions of the cochlea at lower intensities and thus have a longer latency.

scholarly journals Hearing Ability of Prairie Voles (Microtus ochrogaster)

2021 ◽  
Author(s):  
Emily M New ◽  
Ben-Zheng Li ◽  
Tim Lei ◽  
Elizabeth A McCullagh
Keyword(s):  
High Frequency ◽  
Behavioral Responses ◽  
Binaural Hearing ◽  
Auditory Brainstem ◽  
Microtus Ochrogaster ◽  
Auditory Brainstem Responses ◽  
Biparental Care ◽  
Prairie Voles ◽  
Hearing Ability ◽  
Hearing Range

Hearing ability of mammals can be impacted by many factors including social cues, environment, and physical properties of animal morphology. Despite being used commonly to study social behaviors, the hearing ability of the monogamous prairie vole (Microtus ochrogaster) has never been fully characterized. In this study, we measure morphological head and pinna features and use auditory brainstem responses to measure hearing ability of prairie voles characterizing monaural and binaural hearing and hearing range. Additionally, we measured unbonded male and female voles to characterize differences due to sex. We found that prairie voles have intermediate hearing ability with an optimal hearing range of 8 to 32 kHz, robust binaural hearing ability, and characteristic monaural ABRs. We show no differences between the sexes for binaural hearing or hearing range, however female voles have increased amplitude of peripheral ABR waves I and II and increased latency of wave IV. Our results confirm that prairie voles have both low and high frequency hearing, binaural hearing capability, and despite biparental care and monogamy, differences in processing of sound information between the sexes. These data further highlight the necessity to understand sex-specific differences in neural processing that may underly variability in behavioral responses between sexes.

Reliability of Auditory Brainstem Responses from Sequenced High-Frequency (≥ 8 kHz) Tonebursts

1995 ◽  
Vol 34 (4) ◽  
pp. 177-188 ◽  
Author(s):  
Stephen A. Fausti ◽  
Curtin R. Mitchell ◽  
Richard H. Frey ◽  
James A. Henry ◽  
Jody L. O'Connor ◽  
...  
Keyword(s):  
High Frequency ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses

Is it necessary to differentiate tinnitus from auditory hallucination in schizophrenic patients?

2005 ◽  
Vol 119 (5) ◽  
pp. 352-355 ◽  
Author(s):  
Eui-Cheol Nam
Keyword(s):  
Pure Tone ◽  
Auditory Hallucination ◽  
Auditory Brainstem ◽  
Auditory Hallucinations ◽  
Auditory Brainstem Responses ◽  
Hearing Level ◽  
High Frequencies ◽  
Subjective Tinnitus ◽  
Schizophrenic Patients ◽  
Underlying Causes

Although the definitions of subjective tinnitus and auditory hallucination are very similar, the origins and underlying causes of each symptom clearly differ. This study examined whether the differentiation of tinnitus from auditory hallucination is necessary for the proper management of these symptoms in schizophrenic patients. We investigated the characteristics of auditory hallucinations in 15 schizophrenic patients, and measured their pure-tone hearing levels and auditory brainstem responses (ABR). The average hearing level was 20.6 ± 16.2 dB, with a mild decrease at high frequencies. We classified the patients into three groups: pure hallucination, tinnitus, and hallucination plus tinnitus. Eight patients (53.3 per cent) complained of pure-hallucination and only one of them had a mild hearing loss. Hearing deficits were observed in six of seven tinnitus patients. Abnormal findings of ABR were found only in the pure-hallucination group. The results suggest that tinnitus should be differentiated fromauditory hallucination in the evaluation of schizophrenic patients.

scholarly journals Applicability of subcortical EEG metrics of synaptopathy to older listeners with impaired audiograms

2018 ◽  
Author(s):  
Markus Garrett ◽  
Sarah Verhulst
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Sound Pressure ◽  
Outer Hair Cell ◽  
Cell Function ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
Individual Factors ◽  
Noise Floor ◽  
Age Related

AbstractEmerging evidence suggests that cochlear synaptopathy is a common feature of sensorineural hearing loss, but it is not known whether electrophysiological metrics targeting synaptopathy in animals can be applied to a broad range of people, such as those with impaired audiograms. This study investigates the applicability of subcortical electrophysiological measures associated with synaptopathy such as auditory brainstem responses (ABRs) and envelope following responses (EFRs) in older participants with high-frequency sloping audiograms. This is important for the development of reliable and sensitive synaptopathy diagnostics in people with normal or impaired outer-hair-cell function. Broadband click-ABRs at different sound pressure levels and EFRs to amplitude-modulated stimuli were recorded, as well as relative EFR and ABR metrics which reduce individual factors such as head size and noise floor level. Most tested metrics showed significant differences between the groups and did not always follow the trends expected from synaptopathy. Audiometric hearing loss and age-related hearing related deficits interacted to affect the electrophysiological metrics and complicated their interpretation in terms of synaptopathy. This study contributes to a better understanding of how electrophysiological synaptopathy metrics differ in ears with healthy and impaired audiograms, which is an important first step towards unravelling the perceptual consequences of synaptopathy.

scholarly journals Age-related changes of auditory brainstem responses in nonhuman primates

2015 ◽  
Vol 114 (1) ◽  
pp. 455-467 ◽  
Author(s):  
Chi-Wing Ng ◽  
Xochi Navarro ◽  
James R. Engle ◽  
Gregg H. Recanzone
Keyword(s):  
Hearing Loss ◽  
Nonhuman Primates ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
High Frequencies ◽  
Age Related ◽  
Wide Range ◽  
Brainstem Response ◽  
Age Related Hearing Loss ◽  
Age Related Changes

Nonhuman primates, compared with humans and rodents, have historically been far less used for studies of age-related hearing loss, primarily because of their long life span and high cost of maintenance. Strong similarities in genetics, anatomy, and neurophysiology of the auditory nervous system between humans and monkeys, however, could provide fruitful opportunities to enhance our understanding of hearing loss. The present study used a common, noninvasive technique for testing hearing sensitivity in humans, the auditory brainstem response (ABR), to assess the hearing of 48 rhesus macaques from 6 to 35 yr of age to clicks and tone stimuli between 0.5 and 16.0 kHz. Old monkeys, particularly those above 21.5 yr of age, had missing ABR waveforms at high frequencies. Regression analyses revealed that ABR threshold increased as a function of age at peaks II and IV simultaneously. In the suprathreshold hearing condition (70 dB peak sound pressure level), ABR-based audiograms similarly varied as a function of age such that old monkeys had smaller peak amplitudes and delayed latencies at low, middle, and high frequencies. Peripheral hearing differences remained a major influence associated with age-related changes in audiometric functions of old monkeys at a comparable sensation level across animals. The present findings suggest that hearing loss occurs in old monkeys across a wide range of frequencies and that these deficits increase in severity with age. Parallel to prior studies in monkeys, we found weak effects of sex on hearing, and future investigations are necessary to clarify its role in age-related hearing loss.

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