A Short Synthesis of Molnupiravir

Synfacts ◽  
2020 ◽  
Vol 17 (01) ◽  
pp. 0010
Keyword(s):  
Short Synthesis

A Short Synthesis of (+)-Brefeldin C via Enantioselective Radical Hydroalkynylation

2019 ◽  
Author(s):  
Lars Gnägi ◽  
Severin Vital Martz ◽  
Daniel Meyer ◽  
Robin Marc Schärer ◽  
Philippe Renaud
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Oxidation State ◽  
Single Step ◽  
Radical Process ◽  
Target Molecule ◽  
Short Synthesis ◽  
The One

<div><div><div><div><p>A very concise total synthesis of (+)-brefeldin C starting from 2-furanylcyclopentene is described. This approach is based on an unprecedented enantioselective radical hydroalkynylation process to introduce the two cyclopentane stereocenters in a single step. The use of a furan substituent allows to achieve a high trans diastereoselectivity during the radical process and it contains the four carbon atoms C1–C4 of the natural product in an oxidation state closely related to the one of the target molecule. The eight-step synthesis require six product purifications and it provides (+)-brefeldin C in 18% overall yield.</p></div></div></div></div>

A Short Synthesis of the Plant Alkaloid 4-Methyl-2,6-naphthyridine

2019 ◽  
Vol 16 (12) ◽  
pp. 931-934 ◽  
Author(s):  
Alexandra Kamlah ◽  
Franz Bracher
Keyword(s):  
Pyridine Ring ◽  
Cross Coupling ◽  
Antirrhinum Majus ◽  
New Synthesis ◽  
Short Synthesis ◽  
Regioselective Oxidation ◽  
Key Steps

: A new synthesis of the 2,6-naphthyridine alkaloid 4-methyl-2,6-naphthyridine from Antirrhinum majus has been developed. Key steps are a regioselective oxidation of 3-bromo-4,5- dimethylpyridine to the corresponding 4-formyl derivative, and the annulation of the second pyridine ring by Suzuki-Miyaura cross-coupling using (E)-2-ethoxyvinylboronic acid pinacol ester as a masked acetaldehyde equivalent. This protocol gives the alkaloid in four steps starting from commercially available 3,4-dimethylpyridine in 15% overall yield. This annulation protocol should be useful for the synthesis of other condensed pyridines as well.

ChemInform Abstract: A Short Synthesis of (.+-.)-Ricciocarpin a Using Intramolecular Reductive Michael Reaction.

ChemInform ◽  
2010 ◽  
Vol 29 (18) ◽  
pp. no-no
Author(s):  
K. TAKEDA ◽  
N. OHKAWA ◽  
K. HORI ◽  
T. KOIZUMI ◽  
E. YOSHII
Keyword(s):  
Michael Reaction ◽  
Short Synthesis

A short synthesis of naturally occurring and other analogues of plakinic acids that contain the 1,2-dioxolane group

1996 ◽  
Vol 37 (11) ◽  
pp. 1885-1888 ◽  
Author(s):  
A.J. Bloodworth ◽  
Brian D Bothwell ◽  
Andrew N Collins ◽  
Nicola L Maidwell
Keyword(s):  
Naturally Occurring ◽  
Short Synthesis

ChemInform Abstract: A Short Synthesis of 3,6-Disubstituted N-2-Thienyl/Aryl-indoles.

ChemInform ◽  
2010 ◽  
Vol 41 (10) ◽  
Author(s):  
Hanumant B. Borate ◽  
Sangmeshwer P. Sawargave ◽  
Suleman R. Maujan
Keyword(s):  
Short Synthesis

A short synthesis of donor-acceptor substituted CpCo-capped cyclobutadiene-superphanes

1998 ◽  
Vol 39 (37) ◽  
pp. 6695-6698 ◽  
Author(s):  
Gebhard Haberhauer ◽  
Rolf Gleiter
Keyword(s):  
Donor Acceptor ◽  
Short Synthesis

A short synthesis of aromatic analogs of the aranotins

1977 ◽  
Vol 42 (6) ◽  
pp. 948-952 ◽  
Author(s):  
David L. Coffen ◽  
David A. Katonak ◽  
Nels R. Nelson ◽  
Fred D. Sancilio
Keyword(s):  
Short Synthesis
Sign in / Sign up

Export Citation Format

Share Document