Interposed Autologous Nerve Segment Stimulates Nerve Regeneration in Peripheral Nerve Allografts in a Rat Model

2004 ◽  
Vol 20 (2) ◽  
pp. 167-174 ◽  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Rat Model ◽  
Nerve Segment

Biocompatibility and Efficacy of Five-Channel and Eight-Channel Crosslinked Urethane-Doped Polyester Elastomers (CUPEs) as Nerve Guidance Conduit for Reconstruction of Segmental Peripheral Nerve Defect Using Rat Model

2014 ◽  
Vol 21 ◽  
pp. 57-70
Author(s):  
Angela W.H. Ho ◽  
W.Y. Ip
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Rat Model ◽  
Donor Site ◽  
Nerve Graft ◽  
Nerve Tissue ◽  
Histomorphometric Analysis ◽  
Sprague Dawley ◽  
Fiber Density ◽  
Nerve Guidance Conduit

Introduction: Peripheral nerve injury is common in clinical practice. Nerve defect is a challenging scenario. The current gold standard of managing a nerve defect is autologous nerve graft. However, due to the selection of nerve graft and donor site morbidity, artificial nerve conduits are gaining popularity. However, there are drawbacks of single hollow conduit such as lack of internal support to prevent conduit collapse and inability so as to recreate the proper native spatial arrangement of cells and extracellular matrix within the conduit. In this study, the biocompatibility and efficacy of five-channel and eight-channel Crosslinked Urethane-doped Polyester Elastomers (CUPEs) as nerve guidance conduit will be evaluated through a rat model with reconstruction of segmental peripheral nerve defect. Material and Method: Eighteen adult Sprague-Dawley rats were used. They were randomly allocated to three groups: autograft group, five-channel conduit group and eight-channel conduit group with each consisted of six rats. A 10mm nerve defects were created at the right sciatic nerve. They were bridged with reverse autograft, 5-channel conduit and 8-channel conduit. After eight weeks the rats were euthanized and the reconstructed nerves were harvested for histomorphometric analysis. Result: All conduits showed regenerated nerve tissue inside. There was no collapse of the conduits. There were no severe tissue reaction or scarring near the reconstructed nerve. No neuroma was formed. Histomorphometric analysis showed nerve regeneration was enhanced with increasing number of channels inside conduit. There was overall drop in fiber density between proximal and distal segment among all groups. Conclusion: CUPE nerve guidance conduit is biocompatible and shows good nerve regeneration in reconstructing nerve defect.

Peripheral Retrograde Nerve Regeneration After Sciatic Nerve Injury in a Rat Model: A New Concept in Peripheral Nerve Surgery

2017 ◽  
Vol 04 (03) ◽  
Author(s):  
Zermeno Rivera ◽  
Jesus Jaime ◽  
Lopez Martinez Carlos Horacio ◽  
Fajardo Barajas Daniel ◽  
Gonzalez Jaime Jose de Jesus ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Nerve Injury ◽  
Rat Model ◽  
Sciatic Nerve Injury ◽  
Peripheral Nerve Surgery ◽  
Nerve Surgery
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