Dysfunction of the anterior pituitary following traumatic brain injury: A prospective longitudinal study

2007 ◽  
Vol 115 (S 1) ◽  
Author(s):  
A Kleindienst ◽  
D Weigel ◽  
C Bock ◽  
G Brabant ◽  
M Buchfelder
Keyword(s):  
Traumatic Brain Injury ◽  
Longitudinal Study ◽  
Brain Injury ◽  
Anterior Pituitary ◽  
Prospective Longitudinal Study ◽  
Prospective Longitudinal

Intellectual Outcome from Preschool Traumatic Brain Injury: A 5-Year Prospective, Longitudinal Study

PEDIATRICS ◽  
2009 ◽  
Vol 124 (6) ◽  
pp. e1064-e1071 ◽  
Author(s):  
V. Anderson ◽  
C. Catroppa ◽  
S. Morse ◽  
F. Haritou ◽  
J. V. Rosenfeld
Keyword(s):  
Traumatic Brain Injury ◽  
Longitudinal Study ◽  
Brain Injury ◽  
Prospective Longitudinal Study ◽  
Intellectual Outcome ◽  
Prospective Longitudinal

Mild traumatic brain injury and fatigue: A prospective longitudinal study

Brain Injury ◽  
2010 ◽  
Vol 24 (13-14) ◽  
pp. 1528-1538 ◽  
Author(s):  
Joan Norrie ◽  
Marcus Heitger ◽  
Janet Leathem ◽  
Tim Anderson ◽  
Richard Jones ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Longitudinal Study ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Prospective Longitudinal Study ◽  
Prospective Longitudinal

scholarly journals Multicentre longitudinal study of fluid and neuroimaging BIOmarkers of AXonal injury after traumatic brain injury: the BIO-AX-TBI study protocol

BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e042093
Author(s):  
Neil Samuel Nyholm Graham ◽  
Karl A Zimmerman ◽  
Guido Bertolini ◽  
Sandra Magnoni ◽  
Mauro Oddo ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Longitudinal Study ◽  
Brain Injury ◽  
Diffusion Tensor ◽  
Axonal Injury ◽  
Ethics Committee ◽  
Cerebral Microdialysis ◽  
Prospective Longitudinal Study ◽  
Neuroimaging Biomarkers ◽  
Prospective Longitudinal

Introduction and aimsTraumatic brain injury (TBI) often results in persistent disability, due particularly to cognitive impairments. Outcomes remain difficult to predict but appear to relate to axonal injury. Several new approaches involving fluid and neuroimaging biomarkers show promise to sensitively quantify axonal injury. By assessing these longitudinally in a large cohort, we aim both to improve our understanding of the pathophysiology of TBI, and provide better tools to predict clinical outcome.Methods and analysisBIOmarkers of AXonal injury after TBI is a prospective longitudinal study of fluid and neuroimaging biomarkers of axonal injury after moderate-to-severe TBI, currently being conducted across multiple European centres. We will provide a detailed characterisation of axonal injury after TBI, using fluid (such as plasma/microdialysate neurofilament light) and neuroimaging biomarkers (including diffusion tensor MRI), which will then be related to detailed clinical, cognitive and functional outcome measures. We aim to recruit at least 250 patients, including 40 with cerebral microdialysis performed, with serial assessments performed twice in the first 10 days after injury, subacutely at 10 days to 6 weeks, at 6 and 12 months after injury.Ethics and disseminationThe relevant ethical approvals have been granted by the following ethics committees: in London, by the Camberwell St Giles Research Ethics Committee; in Policlinico (Milan), by the Comitato Etico Milano Area 2; in Niguarda (Milan), by the Comitato Etico Milano Area 3; in Careggi (Florence), by the Comitato Etico Regionale per la Sperimentazione Clinica della Regione Toscana, Sezione area vasta centro; in Trento, by the Trento Comitato Etico per le Sperimentazioni Cliniche, Azienda Provinciale per i Servizi Sanitari della Provincia autonoma di Trento; in Lausanne, by the Commission cantonale d’éthique de la recherche sur l’être humain; in Ljubljana, by the National Medical Ethics Committee at the Ministry of Health of the Republic of Slovenia. The study findings will be disseminated to patients, healthcare professionals, academics and policy-makers including through presentation at conferences and peer-reviewed publications. Data will be shared with approved researchers to provide further insights for patient benefit.Trial registration numberNCT03534154.

scholarly journals Prospective memory 7 years after severe childhood traumatic brain injury – the TGE 2 prospective longitudinal study

2016 ◽  
Vol 20 (7) ◽  
pp. 456-461 ◽  
Author(s):  
Agata Krasny-Pacini ◽  
Leila Francillette ◽  
Hanna Toure ◽  
Dominique Brugel ◽  
Anne Laurent-Vannier ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Longitudinal Study ◽  
Brain Injury ◽  
Prospective Memory ◽  
Prospective Longitudinal Study ◽  
Prospective Longitudinal
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