Abnormal ductus venosus streaming toward the right heart offers a new and plausible explanation for left heart hypoplasia in human fetuses with left diaphragmatic hernia

2008 ◽  
Vol 29 (S 2) ◽  
Author(s):  
T Kohl ◽  
A Franz ◽  
A Geipel ◽  
R Stressig ◽  
C Berg ◽  
...  
Keyword(s):  
Diaphragmatic Hernia ◽  
Ductus Venosus ◽  
Human Fetuses ◽  
Left Heart ◽  
Right Heart ◽  
The Right

Preferential Ductus Venosus Streaming Toward the Right Heart Is Associated with Left Heart Underdevelopment and Aortic Arch Hypoplasia in Human Fetuses

2011 ◽  
Vol 32 (S 02) ◽  
pp. E115-E121
Author(s):  
R. Stressig ◽  
R. Axt-Fliedner ◽  
U. Gembruch ◽  
T. Kohl
Keyword(s):  
Aortic Arch ◽  
Diaphragmatic Hernia ◽  
Pulmonary Vein Stenosis ◽  
Ductus Venosus ◽  
Human Fetuses ◽  
Left Heart ◽  
Caval Vein ◽  
Age Related ◽  
The Right ◽  
Aortic Arch Hypoplasia

Abstract Purpose: Preferential left heart underdevelopment in human fetuses with diaphragmatic hernia is almost uniformly associated with preferential streaming of the ductus venosus toward the right side of the heart. The purpose of our study was to examine whether this flow anomaly might also be present in other fetuses with hypoplasia of left-sided cardiovascular structures. Materials and Methods: We studied 32 fetuses with left heart hypoplasia as defined by gestational age-related Z-scores by echocardiography. Apart from defining cardiovascular morphology as detailed as possible, particular focus was put on the presence or absence of preferential streaming of the ductus venosus and inferior caval vein toward the right side of the heart. Results: 8 of 32 fetuses with hypoplasia of one or more left-sided cardiovascular structures exhibited preferential streaming of the ductus venosus toward the right side of the heart. In all eight fetuses, this finding was associated with additional cardiovascular anomalies like aortic valve stenosis, ventricular septal defect, left superior caval vein-to-coronary sinus, pulmonary vein stenosis and/or aortic arch hypoplasia. Conclusion: As in human fetuses with left diaphragmatic hernia, preferential ductus venosus streaming toward the right side of the heart can be found in a subgroup of fetuses with hypoplasia of left-sided cardiovascular structures.

ANOMALIES OF THE PULMONARY VEINS AND THEIR SURGICAL SIGNIFICANCE

PEDIATRICS ◽  
1952 ◽  
Vol 9 (2) ◽  
pp. 152-166
Author(s):  
HARRY G. PARSONS ◽  
ANN PURDY ◽  
BRUCE JESSUP
Keyword(s):  
Superior Vena Cava ◽  
Clinical Symptoms ◽  
Superior Vena ◽  
Pulmonary Veins ◽  
Vena Cava ◽  
Ductus Venosus ◽  
Return Flow ◽  
Right Heart ◽  
Surgical Measures ◽  
The Right

The successful operations upon abnormalities of the outflow tracts of the heart suggest that surgical measures may also be applied to the correction of abnormal inflow tracts. Technically the anastomosis of veins to the auricle has been proved feasible in the experimental animal. Therefore, it should be possible to correct abnormally placed pulmonary veins in man. A wide variety of such anomalies occur. In 55 of 136 reported cases, all the oxygenated blood from the lungs was returned to the right heart through anomalous vessels. Thirty-five per cent of these cases of complete diversion were accompanied by other major cardiac defects. It is estimated that 50% or more of the return flow from the lungs must reach the right heart to produce clinical symptoms. Two cases are presented of persistence of the left superior vena cava which transmitted all the freshly oxygenated blood to the right auricle, by way of the left innominate and the right superior vena cava. The clinical picture was that of growth retardation, minimal cyanosis, a huge hyperactive heart, a loud left mesocardial systolic murmur, pulsating shadows in both upper pulmonary fields, and nearly identical oxygen-saturation of blood obtained from the right heart and femoral artery. One case is reported in which all the oxygenated blood from the lungs is carried to the right auricle by way of the ductus venosus. Surgical correction of the abnormality of these cases by transplantation of one or more of the veins would have been possible. However, no case known to the authors has yet been successfully corrected.

scholarly journals Dust related respiratory pathology and pulmonary hypertension

2008 ◽  
pp. 77-80
Author(s):  
V. V. Razumov ◽  
N. A. Shatskikh ◽  
M. P. Zadorozhnaya
Keyword(s):  
Arterial Hypertension ◽  
Hemodynamic Parameters ◽  
Left Heart ◽  
Heart Ventricle ◽  
Control Groups ◽  
Right Heart ◽  
Pulmonary Hemodynamics ◽  
Initial Stage ◽  
Respiratory Pathology ◽  
The Right

Hemodynamic parameters of right and left heart ventricles and both greater and lesser blood circulations were studied using Doppler echocardiography in 129 patients with arterial hypertension, 54 patients with dust related respiratory pathology and 97 subjects of two control groups. Relying on the results we concluded that (1) the right heart ventricle and pulmonary circulation are targets for arterial hypertension, (2) pressure increase in arteries of lesser circulation occurs at the initial stage of dust related respiratory disease, (3) and the research of pulmonary hemodynamics with functional load should be obligatory when examining relationship between the disease and the profession.

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