Essential Role ofBRCA2in Ovarian Development and Function

Plants seem to be rather defenceless, they are unable to do motion, have no nervous system or immune system unlike animals. Besides this, plants do have hormones, though these substances are produced not in glands. In view of their complexity they lagged behind animals, however, plant organisms show large scale integration in their structure and function. In higher plants, such as in animals, the intercellular communication is fulfilled through chemical messengers. These specific compounds in plants are called phytohormones, or in a wide sense, bioregulators. Even a small quantity of these endogenous organic compounds are able to regulate the operation, growth and development of higher plants, and keep the connection between cells, tissues and synergy beween organs. Since they do not have nervous and immume systems, phytohormones play essential role in plants’ life. Orv. Hetil., 2014, 155(26), 1011–1018.

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Molecular basis of ovarian development and function

Frontiers in Bioscience ◽

10.2741/vander ◽

2002 ◽

Vol 7 (1-3) ◽

pp. d2006 ◽

Cited By ~ 18

Author(s):

Barbara Vanderhyden

Keyword(s):

Molecular Basis ◽

Ovarian Development ◽

And Function

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Faculty Opinions recommendation of Granulosa cell-specific androgen receptors are critical regulators of ovarian development and function.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.5014956.4948054 ◽

2010 ◽

Author(s):

Steve Hillier

Keyword(s):

Granulosa Cell ◽

Ovarian Development ◽

Androgen Receptors ◽

And Function

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Essential Role of Septin 7 in Skeletal Muscle Structure and Function

Biophysical Journal ◽

10.1016/j.bpj.2019.11.1500 ◽

2020 ◽

Vol 118 (3) ◽

pp. 258a

Author(s):

Laszlo Csernoch ◽

Mónika Gönczi ◽

Zsolt Ráduly ◽

László Szabó ◽

Nóra Dobrosi ◽

...

Keyword(s):

Skeletal Muscle ◽

Essential Role ◽

Structure And Function ◽

Muscle Structure ◽

And Function

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Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function

PLoS ONE ◽

10.1371/journal.pone.0212992 ◽

2019 ◽

Vol 14 (3) ◽

pp. e0212992 ◽

Cited By ~ 3

Author(s):

Laurent Dupays ◽

Norma Towers ◽

Sophie Wood ◽

Anna David ◽

Daniel J. Stuckey ◽

...

Keyword(s):

Heart Development ◽

Essential Role ◽

And Function ◽

Transcriptional Target

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Discovery of keratin function and role in genetic diseases: the year that 1991 was

Molecular Biology of the Cell ◽

10.1091/mbc.e15-09-0625 ◽

2016 ◽

Vol 27 (18) ◽

pp. 2807-2810 ◽

Cited By ~ 4

Author(s):

Pierre A. Coulombe

Keyword(s):

Intermediate Filaments ◽

Cell Biology ◽

Essential Role ◽

Genetic Diseases ◽

Structure And Function ◽

Mechanical Support ◽

25Th Anniversary ◽

Keratin Filaments ◽

And Function ◽

Keratin Intermediate Filaments

In 1991, a set of transgenic mouse studies took the fields of cell biology and dermatology by storm in providing the first credible evidence that keratin intermediate filaments play a unique and essential role in the structural and mechanical support in keratinocytes of the epidermis. Moreover, these studies intimated that mutations altering the primary structure and function of keratin filaments underlie genetic diseases typified by cellular fragility. This Retrospective on how these studies came to be is offered as a means to highlight the 25th anniversary of these discoveries.

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PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway

Frontiers in Immunology ◽

10.3389/fimmu.2021.751409 ◽

2022 ◽

Vol 12 ◽

Author(s):

Nianyin Lv ◽

Sufeng Jin ◽

Zihao Liang ◽

Xiaohui Wu ◽

Yanhua Kang ◽

...

Keyword(s):

Immune Response ◽

Dendritic Cells ◽

Experimental Autoimmune Encephalomyelitis ◽

Essential Role ◽

Proteasomal Degradation ◽

Autoimmune Encephalomyelitis ◽

And Function ◽

Essential Subunit ◽

Experimental Autoimmune ◽

Sustained Activation

Dendritic cells (DCs) are recognized as a key orchestrator of immune response and homeostasis, deregulation of which may lead to autoimmunity such as experimental autoimmune encephalomyelitis (EAE). Herein we show that the phosphatase PP2Cδ played a pivotal role in regulating DC activation and function, as PP2Cδ ablation caused aberrant maturation, activation, and Th1/Th17-priming of DCs, and hence induced onset of exacerbated EAE. Mechanistically, PP2Cδ restrained the expression of the essential subunit of mTORC2, Rictor, primarily through de-phosphorylating and proteasomal degradation of the methyltransferase NSD2 via CRL4DCAF2 E3 ligase. Loss of PP2Cδ in DCs accordingly sustained activation of the Rictor/mTORC2 pathway and boosted glycolytic and mitochondrial metabolism. Consequently, ATP-citrate lyse (ACLY) was increasingly activated and catalyzed acetyl-CoA for expression of the genes compatible with hyperactivated DCs under PP2Cδ deletion. Collectively, our findings demonstrate that PP2Cδ has an essential role in controlling DCs activation and function, which is critical for prevention of autoimmunity.

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